Regulation of heat shock transcription factors and their roles in physiology and disease

Nature Reviews Molecular Cell Biology 19, 4 (2018).
doi:10.1038/nrm.2017.73

Authors: Rocio Gomez-Pastor, Eileen T. Burchfiel & Dennis J. Thiele
The heat shock transcription factors (HSFs) were discovered over 30 years ago as direct transcriptional activators of genes regulated by thermal stress, encoding heat shock proteins. The accepted paradigm posited that HSFs exclusively activate the expression of protein chaperones in response to conditions that cause

Source: Nature Reviews Molecular Cell Biology - August 30, 2017 Category: Cytology Authors: Rocio Gomez-Pastor Eileen T. Burchfiel Dennis J. Thiele Tags: Review Source Type: research