Tight junctions: from simple barriers to multifunctional molecular gates

Nature Reviews Molecular Cell Biology 17, 564 (2016). doi:10.1038/nrm.2016.80 Authors: Ceniz Zihni, Clare Mills, Karl Matter & Maria S. Balda Epithelia and endothelia separate different tissue compartments and protect multicellular organisms from the outside world. This requires the formation of tight junctions, selective gates that control paracellular diffusion of ions and solutes. Tight junctions also form the border between the apical and basolateral plasma-membrane domains
Source: Nature Reviews Molecular Cell Biology - Category: Cytology Authors: Tags: Review Source Type: research