Developmental Regulation of Trigeminal TRPA1 by the Cornea [Cornea]
Conclusions.
Corneal-derived factors increase TRPA1 expression in trigeminal nonpeptidergic neurons during their embryonic specification. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - January 6, 2015 Category: Opthalmology Authors: Canner, J. P., Linsenmayer, T. F., Kubilus, J. K. Tags: Cornea Source Type: research
Retinal Nerve Fiber Layer Defect Volume Deviation Analysis Using Spectral-Domain Optical Coherence Tomography [Glaucoma]
Conclusions.
Retinal nerve fiber layer defect volume deviation is a useful tool for diagnosing glaucoma and monitoring RNFL change. In early stage of RNFL loss, RNFL defect volume deviation is more sensitive for detecting glaucoma than the RNFL defect volume measurements. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - January 6, 2015 Category: Opthalmology Authors: Shin, J. W., Uhm, K. B., Seong, M. Tags: Glaucoma Source Type: research
Role of C/EBP Homologous Protein in Retinal Ganglion Cell Death After Ischemia/Reperfusion Injury [Retina]
Conclusions.
Absence of CHOP partially protects against RGC loss and reduction in retinal function after I/R injury, indicating that CHOP and, thus, ER stress play an important role in RGC apoptosis in retinal I/R injury. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - January 2, 2015 Category: Opthalmology Authors: Nashine, S., Liu, Y., Kim, B.-J., Clark, A. F., Pang, I.-H. Tags: Retina Source Type: research
Serum Homocysteine, Vitamin B12, and Folate, and the Prevalence and Incidence of Posterior Subcapsular Cataract [Clinical and Epidemiologic Research]
Conclusions.
Higher serum homocysteine level was associated with PSC prevalence in this population. Vitamin B12 status seemed to modify this association. Lack of longitudinal association could have resulted from insufficient study power. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - January 2, 2015 Category: Opthalmology Authors: Tan, A. G., Mitchell, P., Rochtchina, E., Flood, V. M., Cumming, R. G., Wang, J. J. Tags: Clinical and Epidemiologic Research Source Type: research
Enhanced Structure-Function Relationship in Glaucoma With an Anatomically and Geometrically Accurate Neuroretinal Rim Measurement [Glaucoma]
Conclusions.
The structure–function relationship was enhanced with BMO-MRW compared with the other neuroretinal rim measurements, due mainly to its geometrically accurate properties. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - January 2, 2015 Category: Opthalmology Authors: Danthurebandara, V. M., Sharpe, G. P., Hutchison, D. M., Denniss, J., Nicolela, M. T., McKendrick, A. M., Turpin, A., Chauhan, B. C. Tags: Glaucoma Source Type: research
Neural Circuits That Drive Binocular Eye Movements: Implications for Understanding and Correcting Strabismus [Research Highlight]
(Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - January 2, 2015 Category: Opthalmology Authors: Cullen, K. E. Tags: Research Highlight Source Type: research
Abnormal Activity of Neurons in Abducens Nucleus of Strabismic Monkeys [Eye Movement, Strabismus, Amblyopia, and Neuro-Ophthalmology]
Conclusions.
These data suggest that strabismus can be associated with reduced neural activity in the abducens nucleus. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - January 2, 2015 Category: Opthalmology Authors: Walton, M. M. G., Mustari, M. J., Willoughby, C. L., McLoon, L. K. Tags: Eye Movement, Strabismus, Amblyopia, and Neuro-Ophthalmology Source Type: research
Membrane Protein Transport in Photoreceptors: The Function of PDE{delta} [Lectures]
This lecture details the elucidation of cGMP phosphodiesterase (PDE), discovered 25 years ago by Joe Beavo at the University of Washington. PDE, once identified as a fourth PDE6 subunit, is now regarded as a promiscuous prenyl-binding protein and important chaperone of prenylated small G proteins of the Ras superfamily and prenylated proteins of phototransduction. Alfred Wittinghofer's group in Germany showed that PDE forms an immunoglobulin-like β-sandwich fold that is closely related in structure to other lipid-binding proteins, for example, Uncoordinated 119 (UNC119) and RhoGDI. His group cocrystallized PDE with AR...
Source: Investigative Ophthalmology - December 30, 2014 Category: Opthalmology Authors: Baehr, W. Tags: Lectures Source Type: research
Introducing Wolfgang Baehr, the 2014 Recipient of the Proctor Award [Lectures]
(Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - December 30, 2014 Category: Opthalmology Authors: Wu, S. M. Tags: Lectures Source Type: research
Subcellular Distribution and Activity of Mechanistic Target of Rapamycin in Aged Retinal Pigment Epithelium [Retinal Cell Biology]
Conclusions.
Aging changes the subcellular localization and function of mTOR in the RPE. Increased mTORC1 inhibits POS degradation and may further exacerbate lysosome dysfunction of aged RPE. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - December 30, 2014 Category: Opthalmology Authors: Yu, B., Xu, P., Zhao, Z., Cai, J., Sternberg, P., Chen, Y. Tags: Retinal Cell Biology Source Type: research
Quantitative Imaging of Enzymatic Vitreolysis-Induced Fiber Remodeling [Physiology and Pharmacology]
Conclusions.
Proteoglycan loss due to enzymatic vitreolysis differentially increases fiber alignment at locations where tractions are most common. We hypothesize that a similar mechanism leads to retinal complications during age-related vitreous degeneration. Structural changes to the entire vitreous body (as opposed to the vitreoretinal interface alone) should be evaluated during preclinical testing of pharmacological vitreolysis candidates. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - December 30, 2014 Category: Opthalmology Authors: Filas, B. A., Shah, N. S., Zhang, Q., Shui, Y.-B., Lake, S. P., Beebe, D. C. Tags: Physiology and Pharmacology Source Type: research
The Role of the Hypoxia Response in Shaping Retinal Vascular * Development in the Absence of Norrin/Frizzled4 Signaling [Retinal Cell Biology]
Conclusions.
In the absence of Norrin or Frizzled4, the vascular phenotype is determined by the primary defect in Norrin/Frizzled4 signaling (i.e., canonical Wnt signaling) and compensatory responses resulting from hypoxia. This work may be useful in guiding therapeutic strategies for the treatment of familial exudative vitreoretinopathy (FEVR). (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - December 30, 2014 Category: Opthalmology Authors: Rattner, A., Wang, Y., Zhou, Y., Williams, J., Nathans, J. Tags: Retinal Cell Biology Source Type: research
Identification of Multiple DNA Copy Number Alterations Including Frequent 8p11.22 Amplification in Conjunctival Squamous Cell Carcinoma [Anatomy and Pathology/Oncology]
Conclusions.
Conjunctival SCC contains a range of chromosomal alterations potentially important in tumor formation and growth. Amplification of 8p11.22 and overexpression of ADAM3A suggests a potential role for this protease. Our findings also suggest that defects in DNA repair loci are important in sporadic cSCC. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - December 30, 2014 Category: Opthalmology Authors: Asnaghi, L., Alkatan, H., Mahale, A., Othman, M., Alwadani, S., Al-Hussain, H., Jastaneiah, S., Yu, W., Maktabi, A., Edward, D. P., Eberhart, C. G. Tags: Anatomy and Pathology/Oncology Source Type: research
Optical Quality in Central Serous Chorioretinopathy [Multidisciplinary Ophthalmic Imaging]
Conclusions.
Retinal change affected optical quality and intraocular scatter. Therefore, when the severity of a cataract is assessed using the OQAS, retinal status should be considered when interpreting OQAS values. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - December 30, 2014 Category: Opthalmology Authors: Lee, K., Sohn, J., Choi, J. G., Chung, S. K. Tags: Multidisciplinary Ophthalmic Imaging Source Type: research
Proinflammatory Responses Induced by CD40 in Retinal Endothelial and Muller Cells are Inhibited by Blocking CD40-Traf2,3 or CD40-Traf6 Signaling [Retinal Cell Biology]
Conclusions.
Blockade of a single CD40-TRAF pathway was sufficient to impair ICAM-1, MCP-1, PGE2, and VEGF upregulation in retinal endothelial and/or Müller cells. Blockade of CD40-TRAF signaling may control retinopathies. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - December 30, 2014 Category: Opthalmology Authors: Portillo, J.-A. C., Schwartz, I., Zarini, S., Bapputty, R., Kern, T. S., Gubitosi-Klug, R. A., Murphy, R. C., Subauste, M. C., Subauste, C. S. Tags: Retinal Cell Biology Source Type: research
