Relative Roles of Luminance and Fixation in Inducing Dissociated Vertical Divergence [Eye Movements, Strabismus, Amblyopia, and Neuro-Ophthalmology]
Conclusions.
Dissociated vertical divergence is mediated primarily by changes in fixation and only to a minor degree by binocular luminance disparity. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - February 13, 2015 Category: Opthalmology Authors: Ghadban, R., Liebermann, L., Klaehn, L. D., Holmes, J. M., Brodsky, M. C. Tags: Eye Movements, Strabismus, Amblyopia, and Neuro-Ophthalmology Source Type: research
Surface Engineering of Porous Silicon Microparticles for Intravitreal Sustained Delivery of Rapamycin [Retina]
Conclusions.
Porous silicon–based rapamycin delivery system using the pSiO2-C8 formulation demonstrated good ocular compatibility and may provide sustained drug release for retina. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - February 13, 2015 Category: Opthalmology Authors: Nieto, A., Hou, H., Moon, S. W., Sailor, M. J., Freeman, W. R., Cheng, L. Tags: Retina Source Type: research
Implantation of a Novel Telemetric Intraocular Pressure Sensor in Patients With Glaucoma (ARGOS Study): 1-Year Results [Clinical Trials]
Conclusions.
Despite early postoperative anterior chamber inflammation, the IOP sensor was well tolerated by all patients. We describe the first prospective clinical study of a noncontact IOP sensor that potentially enables continuous IOP monitoring in patients with glaucoma. The sensor shape and size needs to be adapted to avoid pupillary distortion and to confirm that IOP measurements are accurately recorded in comparison to those of GAT. (www.germanctr.de; number DRKS00003335.) (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - February 13, 2015 Category: Opthalmology Authors: Koutsonas, A., Walter, P., Roessler, G., Plange, N. Tags: Clinical Trials Source Type: research
Inhibition of T-Cell Activation by Retinal Pigment Epithelial Cells Derived From Induced Pluripotent Stem Cells [Immunology and Microbiology]
Conclusions.
Cultured iPS-derived retinal cells fully suppress T-cell activation. Transplantation of iPS-RPE cells into the eye might be a therapy for retinal disorders. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - February 13, 2015 Category: Opthalmology Authors: Sugita, S., Kamao, H., Iwasaki, Y., Okamoto, S., Hashiguchi, T., Iseki, K., Hayashi, N., Mandai, M., Takahashi, M. Tags: Immunology and Microbiology Source Type: research
Circadian Control of the Pupillary Light Responses in an Avian Model of Blindness, the GUCY1* Chickens [Retinal Cell Biology]
Conclusions.
Our observations clearly point to circadian control of PLRs even in blindness, strongly indicating that both the entry of light into the eyes and its quality are differentially regulated during the day in diurnal animals. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - February 13, 2015 Category: Opthalmology Authors: Valdez, D. J., Nieto, P. S., Della Costa, N. S., Schurrer, C., Guido, M. E. Tags: Retinal Cell Biology Source Type: research
Restoration of Foveal Thickness and Architecture After Macula-Off Retinal Detachment Repair [Retina]
Conclusions.
Optical coherence tomography scans taken serially at the same location showed a progressive increase of HNL+ONL, ELM-EZ, and EZ-RPE thicknesses and restoration of the integrity of outer retinal bands after repair of fovea-off RRD. The use of software able to rescan at exactly the same area is crucial to correctly follow and interpret the reconstitution of the retinal bands and to correlate them to BCVA recovery. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - February 11, 2015 Category: Opthalmology Authors: dell'Omo, R., Viggiano, D., Giorgio, D., Filippelli, M., Di Iorio, R., Calo', R., Cardone, M., Rinaldi, M., dell'Omo, E., Costagliola, C. Tags: Retina Source Type: research
Automated Retinal Topographic Maps Measured With Magnetic Resonance Imaging [Multidisciplinary Ophthalmic Imaging]
Conclusions.
The possibility to quantitatively characterize the full three-dimensional retinal shape by MRI offers new ophthalmologic possibilities, such as quantitative geometric description of staphyloma. It could in addition be used as a validation technique, independent of standard optical methods, to measure the peripheral retinal shape. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - February 11, 2015 Category: Opthalmology Authors: Beenakker, J.-W. M., Shamonin, D. P., Webb, A. G., Luyten, G. P. M., Stoel, B. C. Tags: Multidisciplinary Ophthalmic Imaging Source Type: research
Self-Perceived Barriers to Eye Care in a Hard-to-Reach Population: The Karachi Marine Fishing Communities Eye and General Health Survey [Clinical and Epidemiologic Research]
Conclusions.
Access to eye care in this marginalized population is substantially hindered by perceived lack of need, financial hardships, and a range of "fears" and anxieties, despite a large unmet need. These barriers should be addressed while paying particular attention to gender, and ethnic and socioeconomic differences. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - February 11, 2015 Category: Opthalmology Authors: Ahmad, K., Zwi, A. B., Tarantola, D. J. M., Chaudhry, T. A. Tags: Clinical and Epidemiologic Research Source Type: research
A Low-Molecular-Weight Oil Cleaner For Removal of Leftover Silicone Oil Intraocular Tamponade [Retina]
Conclusions.
The double-emulsification approach was effective in removing remnant droplets from the eye cavities, and the cleaner was compatible with common cell types encountered in human eyes. The mechanism of toxicity of the proposed cleaner is still unknown, therefore, further in vivo animal tests are needed for full evaluation of the physiological response before the proposed cleaner can be advanced to clinical trials for retinal surgeries. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - February 11, 2015 Category: Opthalmology Authors: Chan, Y. K., Wong, D., Yeung, H. K., Man, P. K., Shum, H. C. Tags: Retina Source Type: research
Canonical/{beta}-Catenin Wnt Pathway Activation Improves Retinal Pigmented Epithelium Derivation From Human Embryonic Stem Cells [Nanotechnology and Regenerative Medicine]
Conclusions.
Our findings demonstrated the importance of canonical/β-catenin Wnt signaling in RPE differentiation and showed that manipulating the pathway significantly improves RPE derivation from hESC. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - February 11, 2015 Category: Opthalmology Authors: Leach, L. L., Buchholz, D. E., Nadar, V. P., Lowenstein, S. E., Clegg, D. O. Tags: Nanotechnology and Regenerative Medicine Source Type: research
miRNA-181a Inhibits the Proliferation, Migration, and Epithelial-Mesenchymal Transition of Lens Epithelial Cells [Lens]
Conclusions.
These data reveal that miR-181a can inhibit the proliferation, migration, and EMT of LECs and suggest that the restoration of miRNA-181a expression may be a potential novel therapeutic target for the prevention and treatment of posterior capsule opacification. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - February 11, 2015 Category: Opthalmology Authors: Dong, N., Tang, X., Xu, B. Tags: Lens Source Type: research
Corneal Epithelial Wound Healing and Bactericidal Effect of Conditioned Medium From Human Uterine Cervical Stem Cells [Cornea]
Conclusions.
Treatment with CM-hUCESCs improved wound healing of alkali-injured corneas and showed a strong bactericidal effect on CLs. Patients using CLs and suffering from dry eye, allergies induced by commercial solutions, or small corneal injuries could benefit from this treatment. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - February 11, 2015 Category: Opthalmology Authors: Bermudez, M. A., Sendon-Lago, J., Eiro, N., Trevino, M., Gonzalez, F., Yebra-Pimentel, E., Giraldez, M. J., Macia, M., Lamelas, M. L., Saa, J., Vizoso, F., Perez-Fernandez, R. Tags: Cornea Source Type: research
Correlation Between Ganglion Cell Layer Thinning and Poor Visual Function After Resolution of Diabetic Macular Edema [Retina]
Conclusions.
Despite favorable anatomic response and restoration of a CMT in the range of normal values after resolution of DME, the GCIPL thickness in r-DME eyes was lower than that in no-DME eyes and correlated with the VA. These results suggest that inner retinal alterations occurring in patients with DME and diabetic retinopathy may lead to visual deficiency persisting after treatment. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - February 11, 2015 Category: Opthalmology Authors: Bonnin, S., Tadayoni, R., Erginay, A., Massin, P., Dupas, B. Tags: Retina Source Type: research
Unaltered Retinal Dopamine Levels in a C57BL/6 Mouse Model of Form-Deprivation Myopia [Anatomy and Pathology/Oncology]
Conclusions.
The retinal dopamine system remains intact in C57BL/6 mice with FDM, and retinal dopamine levels are not associated with the development of FDM in this mouse strain. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - February 11, 2015 Category: Opthalmology Authors: Wu, X.-H., Li, Y.-Y., Zhang, P.-P., Qian, K.-W., Ding, J.-H., Hu, G., Weng, S.-J., Yang, X.-L., Zhong, Y.-M. Tags: Anatomy and Pathology/Oncology Source Type: research
Location of Achromatizing Pupil Position and First Purkinje Reflection in a Normal Population [Visual Psychophysics and Physiological Optics]
Conclusions.
On average, achromatic axis crossing of the pupil and PI locations coincides within measurement errors. Although there was some intersubject variability, differences in location were less than 0.6 mm in all measured eyes. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - February 11, 2015 Category: Opthalmology Authors: Manzanera, S., Prieto, P. M., Benito, A., Tabernero, J., Artal, P. Tags: Visual Psychophysics and Physiological Optics Source Type: research
