Adaptive Optics Imaging of Healthy and Abnormal Regions of Retinal Nerve Fiber Bundles of Patients With Glaucoma [Glaucoma]
Conclusions.
The AO-SLO images revealed details of glaucomatous damage that are difficult, if not impossible, to see with current OCT technology. Adaptive optics SLO may prove useful in following progression in clinical trials, or in disease management, if AO-SLO becomes widely available and easy to use. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - January 29, 2015 Category: Opthalmology Authors: Chen, M. F., Chui, T. Y. P., Alhadeff, P., Rosen, R. B., Ritch, R., Dubra, A., Hood, D. C. Tags: Glaucoma Source Type: research
Sildenafil-Induced Reversible Impairment of Rod and Cone Phototransduction in Monkeys [Retina]
Conclusions.
Sildenafil produced reversible impairment of the rod and cone phototransduction in monkeys. Meanwhile, involvement of the postreceptoral retinal components was suggested. These findings contribute to the clarification of sildenafil-induced visual disturbances. It is suggested that the photoreceptors are predominantly, but not exclusively, affected in the retina of humans with sildenafil-induced visual disturbances. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - January 29, 2015 Category: Opthalmology Authors: Kinoshita, J., Iwata, N., Shimoda, H., Kimotsuki, T., Yasuda, M. Tags: Retina Source Type: research
Rates of Adverse Events With Hydrogel and Silicone Hydrogel Daily Disposable Lenses in a Large Postmarket Surveillance Registry: The TEMPO Registry [Clinical Trials]
Conclusions.
The CIE rates of 0.4% and 0% with these DD lenses are significantly lower than rates reported with reusable SCLs (3%–4%/y), indicating improved safety outcomes with these DD lenses. Compared to unaffected wearers, SiHyDD lens wearers with AEs requiring clinical visits were significantly older. (ClinicalTrials.gov number, NCT01467557.) (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - January 29, 2015 Category: Opthalmology Authors: Chalmers, R. L., Hickson-Curran, S. B., Keay, L., Gleason, W. J., Albright, R. Tags: Clinical Trials Source Type: research
Metanx and Early Stages of Diabetic Retinopathy [Retina]
Conclusions.
Metanx inhibited a diabetes-induced defect in retinal spatial frequency threshold and inhibited measures of oxidative stress and inflammation. It had no significant effect on contrast sensitivity or retinal capillary degeneration. Nutritional management with Metanx may help inhibit diabetes-induced defects in visual function. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - January 29, 2015 Category: Opthalmology Authors: Liu, H., Tang, J., Lee, C. A., Kern, T. S. Tags: Retina Source Type: research
Analysis of Retinal Nonperfusion Using Depth-Integrated Optical Coherence Tomography Images in Eyes With Branch Retinal Vein Occlusion [Retina]
Conclusions.
Depth-integrated OCT images with automated layer segmentation showed a two-dimensional honeycomb-like structure in retinal nonperfusion with retinal edema. In eyes with BRVO, the thickness of retina did not decrease but increased due to retinal cyst in spite of neural retinal thinning. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - January 27, 2015 Category: Opthalmology Authors: Sakimoto, S., Gomi, F., Sakaguchi, H., Akiba, M., Kamei, M., Nishida, K. Tags: Retina Source Type: research
Automatic Identification of Reticular Pseudodrusen Using Multimodal Retinal Image Analysis [Retina]
Conclusions.
Observer performance and agreement for RPD identification improved significantly by using a multimodality grading approach. The developed automatic system showed similar performance as observers, and automatic RPD area quantification was in concordance with manual delineations. The proposed automatic system allows for a fast and accurate identification and quantification of RPD, opening the way for efficient quantitative imaging biomarkers in large data set analysis. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - January 27, 2015 Category: Opthalmology Authors: van Grinsven, M. J. J. P., Buitendijk, G. H. S., Brussee, C., van Ginneken, B., Hoyng, C. B., Theelen, T., Klaver, C. C. W., Sanchez, C. I. Tags: Retina Source Type: research
The Contrast Sensitivity of the Newborn Human Infant [Visual Psychophysics and Physiological Optics]
Conclusions.
The CS of individual newborn human infants can be measured using a fixation-and-following card procedure. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - January 27, 2015 Category: Opthalmology Authors: Brown, A. M., Lindsey, D. T., Cammenga, J. G., Giannone, P. J., Stenger, M. R. Tags: Visual Psychophysics and Physiological Optics Source Type: research
Choroidal Thickness in Relation to Birth Parameters in 11- to 12-Year-Old Children: The Copenhagen Child Cohort 2000 Eye Study [Clinical and Epidemiologic Research]
Conclusions.
In 11- to 12-year-old children, thinner choroids were associated with lower birth weight, lower birth length, and being small for the gestational age. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - January 27, 2015 Category: Opthalmology Authors: Li, X. Q., Munkholm, A., for the Copenhagen Child Cohort 2000 Study Group, Larsen, M., Munch, I. C. Tags: Clinical and Epidemiologic Research Source Type: research
Molecular Method for Bacterial Detection in Contact Lens Storage Cases [Research Highlight]
(Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - January 27, 2015 Category: Opthalmology Authors: de Araujo, A. L. Tags: Research Highlight Source Type: research
Oxidative Stress and Light-Evoked Responses of the Posterior Segment in a Mouse Model of Diabetic Retinopathy [Retinal Cell Biology]
Conclusions.
Apparent diffusion coefficient MRI is a sensitive method for evaluating choroid thickness and its light-evoked expansion together with phototransduction-dependent changes in the SRS layer in mice in vivo. Because ADC MRI exploits an endogenous contrast mechanism, its translational potential is promising; it can also be performed in concert with manganese-enhanced MRI (MEMRI). Our data support a link between diabetes-related oxidative stress and rod, but not choroidal, pathophysiology. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - January 27, 2015 Category: Opthalmology Authors: Berkowitz, B. A., Grady, E. M., Khetarpal, N., Patel, A., Roberts, R. Tags: Retinal Cell Biology Source Type: research
A DNA Dot Hybridization Model for Assessment of Bacterial Bioburden in Orthokeratology Lens Storage Cases [Cornea]
Conclusions.
The dot hybridization assay provides a novel way to assess the bacterial bioburden of OK storage cases. Lens care quality can be assessed with universal bacteria probes, while potentially hazardous bacterial contamination can be traced with genus-specific probes. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - January 27, 2015 Category: Opthalmology Authors: Kuo, M.-T., Chien, C.-C., Lo, J., Hsiao, C.-C., Tseng, S.-L., Lai, Y.-H., Fang, P.-C., Chang, T. C. Tags: Cornea Source Type: research
Viscoelastic Characterization of Extraocular Z-Myotomy [Eye Movements, Strabismus, Amblyopia, and Neuro-Ophthalmology]
Conclusions.
The parallel fiber structure results in low shear force transfer across EOM width, explaining the biomechanics of Z-myotomy. Z-myotomy progressively reduces force transmission to an asymptotic minimum for less than 60% surgical dose, with no further reduction for greater amounts of surgery. Equivalence to EOM specimens having regular cross-sections permits viscoelastic biomechanical characterization of Z-myotomy specimens with irregular cross-sections. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - January 27, 2015 Category: Opthalmology Authors: Shin, A., Yoo, L., Demer, J. L. Tags: Eye Movements, Strabismus, Amblyopia, and Neuro-Ophthalmology Source Type: research
Loss of Thiol Repair Systems in Human Cataractous Lenses [Lens]
Conclusions.
Thiol repair systems were damaged in all types of cataracts. Cortical and nuclear cataracts showed differential G3PD inactivation in the cortex, implying those 2 type of cataracts might be formed through different mechanisms. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - January 23, 2015 Category: Opthalmology Authors: Wei, M., Xing, K.-Y., Fan, Y.-C., Libondi, T., Lou, M. F. Tags: Lens Source Type: research
The Use of Time-Lapse Optical Coherence Tomography to Image the Effects of Microapplied Toxins on the Retina [Physiology and Pharmacology]
Conclusions.
Retinotoxin-induced changes in retinal layer reflectivity and thickness under the microperfusion tube in OCT images closely matched the histological evidence of retinal injury. Time-lapse OCT imaging of the microperfused local retina has the potential to accelerate drug retinotoxicological screening and expand the use of OCT as an evaluation tool for preclinical animal testing. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - January 23, 2015 Category: Opthalmology Authors: Majdi, J. A., Qian, H., Li, Y., Langsner, R. J., Shea, K. I., Agrawal, A., Hammer, D. X., Hanig, J. P., Cohen, E. D. Tags: Physiology and Pharmacology Source Type: research
Brittle Cornea Syndrome ZNF469 Mutation Carrier Phenotype and Segregation Analysis of Rare ZNF469 Variants in Familial Keratoconus [Genetics]
Conclusions.
The presence of heterozygous loss-of-function alleles in the ZNF469 gene did not cause keratoconus in the individuals examined. None of the rare nonsynonymous ZNF469 variants identified in the familial cohort conferred a high risk of keratoconus; therefore, genetic variants contributing to disease pathogenesis in these 11 families remain to be identified. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - January 23, 2015 Category: Opthalmology Authors: Davidson, A. E., Borasio, E., Liskova, P., Khan, A. O., Hassan, H., Cheetham, M. E., Plagnol, V., Alkuraya, F. S., Tuft, S. J., Hardcastle, A. J. Tags: Genetics Source Type: research
