A Double-Blind, Placebo-Controlled Study on the Effects of Lutein and Zeaxanthin on Photostress Recovery, Glare Disability, and Chromatic Contrast [Clinical Trials]
Conclusions.
Daily supplementation with L+Z resulted in significant increase in serum levels and MPOD and improvements in chromatic contrast and recovery from photostress. These results are consistent with past studies showing that increasing MPOD leads to improved visual performance. (ClinicalTrials.gov number, NCT00909090.) (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - December 30, 2014 Category: Opthalmology Authors: Hammond, B. R., Fletcher, L. M., Roos, F., Wittwer, J., Schalch, W. Tags: Clinical Trials Source Type: research
Morphometry of the Trochlear Nerve and Superior Oblique Muscle Volume in Congenital Superior Oblique Palsy [Eye Movement, Strabismus, Amblyopia, and Neuro-Ophthalmology]
Conclusions.
In congenital SOP patients without a trochlear nerve, the nonparetic side CN4D was also reduced in contrast to those with a trochlear nerve. The relatively weaker relationship of CN4D and nonparetic side SO volume in the absent group than that of the present group suggests different pathogenic mechanisms underlying these two entities of congenital SOP. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - December 29, 2014 Category: Opthalmology Authors: Lee, D. S., Yang, H. K., Kim, J. H., Hwang, J.-M. Tags: Eye Movement, Strabismus, Amblyopia, and Neuro-Ophthalmology Source Type: research
Relationship Between Transient and Steady-State Pattern Electroretinograms: Theoretical and Experimental Assessment [Visual Neuroscience]
Conclusions.
The study shows that PERGSS results from the overlapping of tr PERGtr waveforms generated at that reversal rate. The first two peaks (NSS and PSS) of the PERGSS reflect N35 and P50 waves of the tr PERGtr. The N95 amplitude is reduced at conventional (16 rps) SS rates, but contributes to the overall PERGSS amplitude. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - December 29, 2014 Category: Opthalmology Authors: Ozdamar, O., Toft-Nielsen, J., Bohorquez, J., Porciatti, V. Tags: Visual Neuroscience Source Type: research
ALSPAC Study Does Not Support a Role for Vitamin D in the Prevention of Myopia [Research Highlight]
(Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - December 29, 2014 Category: Opthalmology Authors: Morgan, I. G., Rose, K. A. Tags: Research Highlight Source Type: research
Does Vitamin D Mediate the Protective Effects of Time Outdoors On Myopia? Findings From a Prospective Birth Cohort [Clinical and Epidemiologic Research]
Conclusions.
Total vitamin D and D3 were biomarkers for time spent outdoors, however there was no evidence they were independently associated with future myopia. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - December 29, 2014 Category: Opthalmology Authors: Guggenheim, J. A., Williams, C., Northstone, K., Howe, L. D., Tilling, K., St Pourcain, B., McMahon, G., Lawlor, D. A. Tags: Clinical and Epidemiologic Research Source Type: research
The Impact of Lack of Government-Insured Routine Eye Examinations on the Incidence of Self-Reported Glaucoma, Cataracts, and Vision Loss [Clinical and Epidemiologic Research]
Conclusions.
Lack of government-funded routine eye examinations is associated with a reduced incidence of self-reported glaucoma and cataracts, likely due to reduced detection. Lack of insurance also is associated with a higher incidence of self-reported vision loss, likely due to poorer access to eye care and late treatment. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - December 29, 2014 Category: Opthalmology Authors: Chan, C. H., Trope, G. E., Badley, E. M., Buys, Y. M., Jin, Y.-P. Tags: Clinical and Epidemiologic Research Source Type: research
Author Response: Association of Focal Choroidal Excavation With Age-Related Macular Degeneration [Letters]
(Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - December 29, 2014 Category: Opthalmology Authors: Kuroda, Y., Tsujikawa, A., Yoshimura, N. Tags: Letters Source Type: research
Association of Focal Choroidal Excavation With Age-Related Macular Degeneration [Letters]
(Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - December 29, 2014 Category: Opthalmology Authors: Querques, G. Tags: Letters Source Type: research
Neurosteroids Are Endogenous Neuroprotectants in an Ex Vivo Glaucoma Model [Glaucoma]
Conclusions.
These results indicate that the synthesis of allopregnanolone is enhanced mainly via NMDARs in the pressure-loaded retina, and that allopregnanolone diminishes pressure-mediated retinal degeneration via GABAA receptors. Allopregnanolone and other related neurosteroids may serve as potential novel therapeutic targets for the prevention of pressure-induced retinal damage in glaucoma. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - December 29, 2014 Category: Opthalmology Authors: Ishikawa, M., Yoshitomi, T., Zorumski, C. F., Izumi, Y. Tags: Glaucoma Source Type: research
Cytokine Production and Antigen Recognition by Human Mucosal Homing Conjunctival Effector Memory CD8+ T Cells [Immunology and Microbiology]
Conclusions.
These data demonstrate that the majority of conjunctival epithelial CD8+ T cells are mucosal homing αEβ7+ effector memory T cells, which can recognize viral epitopes and are capable of secreting Granzyme B and IFN-. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - December 29, 2014 Category: Opthalmology Authors: Williams, G. P., Pachnio, A., Long, H. M., Rauz, S., Curnow, S. J. Tags: Immunology and Microbiology Source Type: research
Retinal Hemorheologic Characterization of Early-Stage Diabetic Retinopathy Using Adaptive Optics Scanning Laser Ophthalmoscopy [Retina]
Conclusions.
AO-SLO can be used to detect retinal hemorheologic changes in the early stages of diabetic retinopathy. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - December 29, 2014 Category: Opthalmology Authors: Arichika, S., Uji, A., Murakami, T., Unoki, N., Yoshitake, S., Dodo, Y., Ooto, S., Miyamoto, K., Yoshimura, N. Tags: Retina Source Type: research
Appositional Angle Closure in Chinese With Primary Angle Closure and Primary Angle Closure Glaucoma After Laser Peripheral Iridotomy [Glaucoma]
Conclusions.
Approximately two-thirds of PAC and PACG eyes of Chinese patients after LPI had AAC. Plateau iris accounted for less than 50% of AAC. Other factors such as a thick peripheral iris and an anteriorly inserted iris also contributed to AAC. DRPT results suggested AAC might have more functional meaning than plateau iris. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - December 29, 2014 Category: Opthalmology Authors: Yan, Y.-j., Wu, L.-l., Wang, X., Xiao, G.-g. Tags: Glaucoma Source Type: research
Ocular Perfusion Pressure During Pars Plana Vitrectomy: A Pilot Study [Retina]
Conclusions.
The MOPP may decrease significantly in course of PPV, acutely and for longer time. Surgical maneuvers, including silicone oil removal and combined phacoemulsification, pose a higher risk for MOPP reduction. Discretion should be exercised while administering deep sedation, since it may further lower MOPP through undue blood pressure reduction. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - December 29, 2014 Category: Opthalmology Authors: Rossi, T., Querzoli, G., Angelini, G., Rossi, A., Malvasi, C., Iossa, M., Ripandelli, G. Tags: Retina Source Type: research
Targeted Exon Sequencing in Usher Syndrome Type I [Biochemistry and Molecular Biology]
Conclusions.
We found a remarkable genetic heterogeneity in the studied USH1 cohort with multiplicity of mutations, of which many were novel. No obvious influence of genotype on phenotype was found, possibly due to small sample sizes of the genotypes under study. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - December 29, 2014 Category: Opthalmology Authors: Bujakowska, K. M., Consugar, M., Place, E., Harper, S., Lena, J., Taub, D. G., White, J., Navarro-Gomez, D., Weigel DiFranco, C., Farkas, M. H., Gai, X., Berson, E. L., Pierce, E. A. Tags: Biochemistry and Molecular Biology Source Type: research
Differential Expression and Function of Survivin During the Progress of Pterygium [Cornea]
Conclusions.
Higher subcellular expression and phosphorylation of survivin may play roles in the development of pterygium. Survivin could be targeted for the treatment of pterygium. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - December 29, 2014 Category: Opthalmology Authors: Xu, Y.-x., Zhang, L.-y., Zou, D.-l., Liu, Z.-s., Shang, X.-m., Wu, H.-p., Zhou, Y., He, H., Liu, Z.-g. Tags: Cornea Source Type: research
