Horizontal Intracorneal Swirling Water Migration Indicative of Corneal Endothelial Function [Cornea]
Conclusions.
We report for the first time the presence of horizontal water migration in the cornea in a swirling pattern (i.e., intracorneal swirling migration of water, generated by the pump function in the corneal endothelial cells), which may supplement the conventional concept of development of corneal edema in the vertical plane. This dynamic water circulatory system may be involved in increasing the efficiency of the water transfer in the entire cornea. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - December 10, 2014 Category: Opthalmology Authors: Inoue, T., Kobayashi, T., Nakao, S., Hara, Y., Suzuki, T., Hayashi, Y., Zheng, X., Shiraishi, A., Ohashi, Y. Tags: Cornea Source Type: research
A Positive Association Between Intrinsically Photosensitive Retinal Ganglion Cells and Retinal Nerve Fiber Layer Thinning in Glaucoma [Glaucoma]
Conclusions.
This study showed a correlation between the mean RNFL thickness and the pupillary light response. A decrease in the number of ipRGCs is potentially related to the reduced RNFL thickness. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - December 10, 2014 Category: Opthalmology Authors: Gracitelli, C. P. B., Duque-Chica, G. L., Moura, A. L., Nagy, B. V., de Melo, G. R., Roizenblatt, M., Borba, P. D., Teixeira, S. H., Ventura, D. F., Paranhos, A. Tags: Glaucoma Source Type: research
Laser Speckle and Hydrogen Gas Clearance Measurements of Optic Nerve Circulation in Albino and Pigmented Rabbits With or Without Optic Disc Atrophy [Multidisciplinary Ophthalmic Imaging]
Conclusions.
Regardless of the presence of fundus pigmentation or ONH atrophy, ONH MBR and ONH CBF were highly correlated, suggesting that MBR in the ONH tissue is usable for interindividual and intergroup comparisons. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - December 10, 2014 Category: Opthalmology Authors: Aizawa, N., Nitta, F., Kunikata, H., Sugiyama, T., Ikeda, T., Araie, M., Nakazawa, T. Tags: Multidisciplinary Ophthalmic Imaging Source Type: research
Natural History of Corneal Nerve Morphology in Mild Neuropathy Associated With Type 1 Diabetes: Development of a Potential Measure of Diabetic Peripheral Neuropathy [Cornea]
Conclusions.
This study demonstrates dynamic small fiber damage at the SNP, thus providing justification for our ongoing efforts to establish corneal nerve morphology as an appropriate adjunct to conventional measures of diabetic peripheral neuropathy. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - December 10, 2014 Category: Opthalmology Authors: Dehghani, C., Pritchard, N., Edwards, K., Vagenas, D., Russell, A. W., Malik, R. A., Efron, N. Tags: Cornea Source Type: research
Development and Reliability of Retinal Arteriolar Central Light Reflex Quantification System: A New Approach for Severity Grading [Retina]
Conclusions.
Quantitative assessment of retinal arteriolar wall opacification is a reliable method using a new computer-assisted system. This new CRR measurement system is a potentially useful tool to study retinal arteriolar abnormalities with systemic diseases. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - December 10, 2014 Category: Opthalmology Authors: Bhuiyan, A., Cheung, C. Y., Frost, S., Lamoureux, E., Mitchell, P., Kanagasingam, Y., Wong, T. Y. Tags: Retina Source Type: research
FoxO1 Gene Confers Genetic Predisposition to Acute Anterior Uveitis With Ankylosing Spondylitis [Genetics]
Conclusion.
This study suggests that FoxO1, but not miR-27a, miR-182, and IL2RA, contributes to the genetic susceptibility of AAU with AS, but none of the tested polymorphisms confer risk to AAU without AS. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - December 10, 2014 Category: Opthalmology Authors: Yu, H., Liu, Y., Zhang, L., Wu, L., Zheng, M., Cheng, L., Luo, L., Kijlstra, A., Yang, P. Tags: Genetics Source Type: research
Hyperosmolar Stress Induces Neutrophil Extracellular Trap Formation: Implications for Dry Eye Disease [Cornea]
Conclusions.
Hyperosmolarity induces formation of NETs by neutrophils. This NETosis mechanism may explain the presence of excessive NETs on the ocular surface of patients with dry eye disease. Because they reduce hyperosmolarity-induced NETosis, FPR2 agonists may have therapeutic potential in these patients. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - December 10, 2014 Category: Opthalmology Authors: Tibrewal, S., Ivanir, Y., Sarkar, J., Nayeb-Hashemi, N., Bouchard, C. S., Kim, E., Jain, S. Tags: Cornea Source Type: research
CEACAM1 Confers Resistance Toward Oxygen-Induced Vessel Damage in a Mouse Model of Retinopathy of Prematurity [Retina]
Conclusions.
Our report describes a functional role for CEACAM1 in retinal neovascularization in a mouse model of OIR. This is the first study demonstrating that CEACAM1 enhances vascular remodeling and tuft regression by increasing endothelial resistance to alterations in oxygen tension, thus accelerating vascular recovery after systemic hypoxia. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - December 10, 2014 Category: Opthalmology Authors: Ludewig, P., Flachsbarth, K., Wegscheid, C., Tiegs, G., Richard, G., Wagener, C., Bartsch, U., Horst, A. K. Tags: Retina Source Type: research
Human Eye Development Is Characterized by Coordinated Expression of Fibrillin Isoforms [Anatomy and Pathology/Oncology]
Conclusions.
Fibrillin-1, -2, and, unique to humans, fibrillin-3 are found in various ocular structures during human embryonic eye development, whereas fibrillin-1 dominates the postnatal zonule. We speculate that vasculature spanning the ciliary body and lens, which elaborates fibrillin-2 and -3, may provide an initial scaffold for fibrillin assembly and zonule formation. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - December 10, 2014 Category: Opthalmology Authors: Hubmacher, D., Reinhardt, D. P., Plesec, T., Schenke-Layland, K., Apte, S. S. Tags: Anatomy and Pathology/Oncology Source Type: research
Reconstruction of the Limbal Vasculature After Limbal-Conjunctival Autograft Transplantation in Pterygium Surgery: An Angiography Study [Cornea]
Conclusions.
The pterygium had a dual blood supply, and the remodeling of the affected limbus and LCA continued up to 3 months postoperatively. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - December 9, 2014 Category: Opthalmology Authors: Kim, Y. J., Yoo, S. H., Chung, J. K. Tags: Cornea Source Type: research
The Location- and Depth-Dependent Mechanical Response of the Human Cornea Under Shear Loading [Cornea]
Conclusions.
This study demonstrates that the peak shear modulus of the human cornea occurs at a substantial distance within the corneal stroma. Depth-dependent differences between central and peripheral cornea possibly reflect the location-dependent mechanical environment of the cornea. Moreover, the cornea is not a transverse isotropic material, and must be characterized by more than a single shear modulus due to its dependence on loading direction. The material properties measured in this study are critical for developing accurate mechanical models to predict the vision-threatening morphological changes that can occur i...
Source: Investigative Ophthalmology - December 9, 2014 Category: Opthalmology Authors: Sloan, S. R., Khalifa, Y. M., Buckley, M. R. Tags: Cornea Source Type: research
The Cellular Origins of the Outer Retinal Bands in Optical Coherence Tomography Images [Multidisciplinary Ophthalmic Imaging]
Conclusions.
On the basis of these findings, we suggest that ascription of the outer retinal band 2 to the inner segment ellipsoid is unjustified, because the ellipsoid is both too thick and proximally located to produce the band. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - December 9, 2014 Category: Opthalmology Authors: Jonnal, R. S., Kocaoglu, O. P., Zawadzki, R. J., Lee, S.-H., Werner, J. S., Miller, D. T. Tags: Multidisciplinary Ophthalmic Imaging Source Type: research
Objective Assessment of Corneal Staining Using Digital Image Analysis [Cornea]
Conclusions.
The new algorithm showed excellent correlation with the traditional subjective clinical grading scales. It may be useful for objective assessment of corneal staining, independent of disease conditions. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - December 9, 2014 Category: Opthalmology Authors: Chun, Y. S., Yoon, W. B., Kim, K. G., Park, I. K. Tags: Cornea Source Type: research
Chronic Hypertension Increases Susceptibility to Acute IOP Challenge in Rats [Glaucoma]
Conclusions.
Acute BP elevation makes retinal function and blood flow less susceptible to IOP elevation. The reduced susceptibility afforded by improved ocular perfusion pressure is compromised after 4 weeks of chronic hypertension. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - December 9, 2014 Category: Opthalmology Authors: He, Z., Vingrys, A. J., Armitage, J. A., Nguyen, C. T., Bui, B. V. Tags: Glaucoma Source Type: research
Models of Glaucomatous Visual Field Loss [Glaucoma]
Conclusions.
While the logistic model best fit glaucomatous VF behavior over a long time period, the exponential model provided the best average predictions. A multiple-model approach for VF predictions was associated with a greater prediction error than with the best-performing single-model approach. A model's goodness of fit is not indicative of its predictive ability for measurements of glaucomatous VFs. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - December 9, 2014 Category: Opthalmology Authors: Chen, A., Nouri-Mahdavi, K., Otarola, F. J., Yu, F., Afifi, A. A., Caprioli, J. Tags: Glaucoma Source Type: research
