CEACAM1 Confers Resistance Toward Oxygen-Induced Vessel Damage in a Mouse Model of Retinopathy of Prematurity [Retina]

Conclusions.
Our report describes a functional role for CEACAM1 in retinal neovascularization in a mouse model of OIR. This is the first study demonstrating that CEACAM1 enhances vascular remodeling and tuft regression by increasing endothelial resistance to alterations in oxygen tension, thus accelerating vascular recovery after systemic hypoxia.

Source: Investigative Ophthalmology - December 10, 2014 Category: Opthalmology Authors: Ludewig, P., Flachsbarth, K., Wegscheid, C., Tiegs, G., Richard, G., Wagener, C., Bartsch, U., Horst, A. K. Tags: Retina Source Type: research