PRIMPOL Mutation: Functional Study Does Not Always Reveal the Truth [Letters]
(Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - February 13, 2015 Category: Opthalmology Authors: Li, J., Zhang, Q. Tags: Letters Source Type: research
Activation of Liver X Receptor Protects Inner Retinal Damage Induced by N-methyl-D-aspartate [Retina]
Conclusions.
Activation of LXRβ with a synthetic LXR ligand TO90 protects the inner retinal damage induced by NMDA in mice. We speculate the protective effect is associated with inhibition of the NF-B signaling pathway and reduction of Aβ formation in retina. The LXR agonists may become a new class of neuroprotective agent for retinal diseases associated with glutamate-induced excitotoxicity. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - February 13, 2015 Category: Opthalmology Authors: Zheng, S., Yang, H., Chen, Z., Zheng, C., Lei, C., Lei, B. Tags: Retina Source Type: research
Relationship of Retinal Morphology and Retinal Sensitivity in the Treatment of Neovascular Age-Related Macular Degeneration Using Aflibercept [Retina]
Conclusions.
Significant functional benefits following intravitreal aflibercept treatment could be detected over all defined morphological pathologies. The level of improvement varied dependent on the associated feature with the best prognosis for visual improvement in SRF and sPED and least with intraretinal fluid and particularly intraretinal cysts. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - February 13, 2015 Category: Opthalmology Authors: Sulzbacher, F., Roberts, P., Munk, M. R., Kaider, A., Kroh, M. E., Sacu, S., Schmidt-Erfurth, U., for the Vienna Eye Study Center Tags: Retina Source Type: research
A New Small Molecule For Treating Inflammation and Chorioretinal Neovascularization in Relapsing-Remitting and Chronic Experimental Autoimmune Uveitis [Immunology and Microbiology]
Conclusions.
We investigated a new dihydroorotate dehydrogenase inhibitor as treatment for primary and recurrent disease in relapsing-remitting and chronic rat models of experimental autoimmune uveitis. The small molecule compound PP-001 suppressed proliferation and cytokine secretion of autoreactive T cells (i.e., IFN-g, IL-17, and VEGF) and chorioretinal neovascularization in chronic EAU. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - February 13, 2015 Category: Opthalmology Authors: Diedrichs-Mohring, M., Leban, J., Strobl, S., Obermayr, F., Wildner, G. Tags: Immunology and Microbiology Source Type: research
Factors Associated With Persistent Subfoveal Fluid and Complete Macular Hole Closure in the PIONEER Study [Retina]
Conclusions.
Persistent subfoveal fluid following MH surgery is a common finding that appears to delay visual recovery but not effect final visual outcome. The incidence of persistent subfoveal fluid appears to be related to intraoperative alterations after ILM peeling in the outer retinal architecture (e.g., increased EZ-RPE height and SRHR width). This finding suggests a novel mechanism for facilitating MH closure through ILM peeling (e.g., altering photoreceptor/RPE adherence and increasing retinal mobility that allows for complete hole closure). (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - February 13, 2015 Category: Opthalmology Authors: Ehlers, J. P., Itoh, Y., Xu, L. T., Kaiser, P. K., Singh, R. P., Srivastava, S. K. Tags: Retina Source Type: research
Complex I Subunit Gene Therapy With NDUFA6 Ameliorates Neurodegeneration in EAE [Eye Movements, Strabismus, Amblyopia, and Neuro-Ophthalmology]
Conclusions.
NDUFA6 gene therapy provided long-term suppression of neurodegeneration in the EAE animal model suggesting that it may also ameliorate the mitochondrial dysfunction associated with permanent disability in optic neuritis and MS patients. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - February 13, 2015 Category: Opthalmology Authors: Talla, V., Koilkonda, R., Porciatti, V., Chiodo, V., Boye, S. L., Hauswirth, W. W., Guy, J. Tags: Eye Movements, Strabismus, Amblyopia, and Neuro-Ophthalmology Source Type: research
Role of Soluble Vascular Endothelial Growth Factor Receptor Signaling and Other Factors or Cytokines in Central Retinal Vein Occlusion With Macular Edema [Retina]
Conclusions.
These findings suggest that growth/inflammatory factors and cytokines have an important role in macular edema associated with CRVO. Better understanding of the mechanisms involved may lead to development of new treatments, such as anti–VEGFR-1 therapy. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - February 13, 2015 Category: Opthalmology Authors: Noma, H., Mimura, T., Yasuda, K., Shimura, M. Tags: Retina Source Type: research
Smoking Causes Blindness: Time for Eye Care Professionals to Join the Fight Against Tobacco [Perspectives]
This report provides new evidence about the link between cigarette smoking and eye disease, which signifies a new role for eye-care professionals in tobacco control on two levels. First, on a clinical level, eye care professionals should integrate smoking cessation treatment in the standard care of patients' management in eye-care settings in order to motivate and help smoking patients in quitting smoking. Second, on a political level, eye care providers can serve as powerful public advocates against tobacco use, thereby significantly enhancing public awareness about the link between smoking and eye disease. (Source: Inves...
Source: Investigative Ophthalmology - February 13, 2015 Category: Opthalmology Authors: Asfar, T., Lam, B. L., Lee, D. J. Tags: Perspectives Source Type: research
Author Response: Changes of Choroidal Thickness After Phacoemulsification [Letters]
(Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - February 13, 2015 Category: Opthalmology Authors: Baillif, S., Pierru, A. Tags: Letters Source Type: research
Changes of Choroidal Thickness After Phacoemulsification [Letters]
(Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - February 13, 2015 Category: Opthalmology Authors: He, M., Huang, W. Tags: Letters Source Type: research
Prevalence and Racial Differences in Pterygium: A Cross-Sectional Study in Han and Uygur Adults in Xinjiang, China [Clinical and Epidemiologic Research]
Conclusions.
Pterygium affects approximately one-ninth of Han and Uygur population. Compared with Uygur, Han ethnicity is a significant risk factor of pterygium. Our results indicated a higher prevalence of pterygium in rural areas of Xinjiang, China compared with urban cities. Age increase was also associated with presence of pterygium. Strategies are warranted to prevent the serious effects caused by pterygium. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - February 13, 2015 Category: Opthalmology Authors: Chen, T., Ding, L., Shan, G., Ke, L., Ma, J., Zhong, Y. Tags: Clinical and Epidemiologic Research Source Type: research
Semaphorin 7a in Herpetic Neurotrophic Keratitis [Research Highlight]
(Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - February 13, 2015 Category: Opthalmology Authors: Shukla, D. Tags: Research Highlight Source Type: research
Degeneration and Regeneration of Corneal Nerves in Response to HSV-1 Infection [Cornea]
Conclusions.
Corneal sensory nerves were lost, consistent with loss of corneal sensation at day 8 pi. At day 30 pi, the cornea reinnervated but without recovering the normal arrangement of its fibers or function. SEMA 7A expression was increased at day 8pi, likely as part of a nerve regeneration mechanism. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - February 13, 2015 Category: Opthalmology Authors: Chucair-Elliott, A. J., Zheng, M., Carr, D. J. J. Tags: Cornea Source Type: research
Cyclocoagulation of the Ciliary Bodies by High-Intensity Focused Ultrasound: A 12-Month Multicenter Study [Clinical Trials]
Conclusions.
The new miniaturized HIFU EyeOP1 delivery device seems to be effective in decreasing IOP in patients with refractory glaucoma. The technology offers a good safety profile. (ClinicalTrials.gov number, NCT01338467.) (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - February 13, 2015 Category: Opthalmology Authors: Denis, P., Aptel, F., Rouland, J.-F., Nordmann, J.-P., Lachkar, Y., Renard, J.-P., Sellem, E., Baudouin, C., Bron, A. Tags: Clinical Trials Source Type: research
The Enigma of Luminance and Fixation in Dissociated Strabismus [Research Highlight]
(Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - February 13, 2015 Category: Opthalmology Authors: Chaudhuri, Z. Tags: Research Highlight Source Type: research
