Pharmacokinetics of Bevacizumab and Its Effects on Serum VEGF and IGF-1 in Infants With Retinopathy of Prematurity [Biochemistry and Molecular Biology]
Conclusions.
Clearance of bevacizumab from the bloodstream in premature infants takes at least 2 months. Although serum free VEGF levels decreased following either laser or bevacizumab treatment, the reductions were more significant in the IVB-treated groups. Potential long-term effects of systemic exposure to bevacizumab in infants need to be studied further. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - February 9, 2015 Category: Opthalmology Authors: Kong, L., Bhatt, A. R., Demny, A. B., Coats, D. K., Li, A., Rahman, E. Z., Smith, O. E., Steinkuller, P. G. Tags: Biochemistry and Molecular Biology Source Type: research
Saccadic Adaptation in Visually Normal Individuals Using Saccadic Endpoint Variability From Amblyopia [Eye Movements, Strabismus, Amblyopia, and Neuro-Ophthalmology]
Conclusions.
Our findings indicate that adding exogenous spatial noise to the adapting step consistent with the saccadic endpoint variability difference between amblyopic and visually normal groups is sufficient to reduce saccadic adaptation in healthy individuals. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - February 9, 2015 Category: Opthalmology Authors: Raashid, R. A., Wong, A. M. F., Blakeman, A., Goltz, H. C. Tags: Eye Movements, Strabismus, Amblyopia, and Neuro-Ophthalmology Source Type: research
Microarray Analysis of Gene Expression in Fibrovascular Membranes Excised From Patients With Proliferative Diabetic Retinopathy [Retinal Cell Biology]
Conclusions.
Our data indicate that extracellular matrix-related molecules such as POSTN, TNC, TGFβ, and angiogenic factors have important roles in promoting the development of FVMs associated with PDR. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - February 9, 2015 Category: Opthalmology Authors: Ishikawa, K., Yoshida, S., Kobayashi, Y., Zhou, Y., Nakama, T., Nakao, S., Sassa, Y., Oshima, Y., Niiro, H., Akashi, K., Kono, T., Ishibashi, T. Tags: Retinal Cell Biology Source Type: research
Advancing Therapeutic Strategies for Inherited Retinal Degeneration: Recommendations From the Monaciano Symposium [Reviews]
Although rare in the general population, retinal dystrophies occupy a central position in current efforts to develop innovative therapies for blinding diseases. This status derives, in part, from the unique biology, accessibility, and function of the retina, as well as from the synergy between molecular discoveries and transformative advances in functional assessment and retinal imaging. The combination of these factors has fueled remarkable progress in the field, while at the same time creating complex challenges for organizing collective efforts aimed at advancing translational research. The present position paper outlin...
Source: Investigative Ophthalmology - February 9, 2015 Category: Opthalmology Authors: Thompson, D. A., Ali, R. R., Banin, E., Branham, K. E., Flannery, J. G., Gamm, D. M., Hauswirth, W. W., Heckenlively, J. R., Iannaccone, A., Jayasundera, K. T., Khan, N. W., Molday, R. S., Pennesi, M. E., Reh, T. A., Weleber, R. G., Zacks, D. N., for the Tags: Reviews Source Type: research
Temporal Summation in Children With a History of Retinopathy of Prematurity [Visual Neuroscience]
Conclusions.
In ROP subjects, tCRIT is significantly prolonged. This is likely due to abnormal kinetics in the rod outer segment. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - February 9, 2015 Category: Opthalmology Authors: Hansen, R. M., Moskowitz, A., Tavormina, J. L., Bush, J. N., Soni, G., Fulton, A. B. Tags: Visual Neuroscience Source Type: research
Delay in Retinal Photoreceptor Development in Very Preterm Compared to Term Infants [Retina]
Conclusions.
Photoreceptor inner and outer segment development in VPT infants appears delayed when compared to term infants, and the photoreceptor RPE junction remains immature in all infants at TEA. Delayed maturation of photoreceptors could contribute to differences in visual function in some VPT infants. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - February 9, 2015 Category: Opthalmology Authors: Vajzovic, L., Rothman, A. L., Tran-Viet, D., Cabrera, M. T., Freedman, S. F., Toth, C. A. Tags: Retina Source Type: research
Neuroprotective Effects of Transcription Factor Brn3b in an Ocular Hypertension Rat Model of Glaucoma [Glaucoma]
Conclusions.
Adeno-associated virus–mediated Brn3b protein expression may be a suitable approach for promoting neuroprotection in animal models of glaucoma. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - February 9, 2015 Category: Opthalmology Authors: Stankowska, D. L., Minton, A. Z., Rutledge, M. A., Mueller, B. H., Phatak, N. R., He, S., Ma, H.-Y., Forster, M. J., Yorio, T., Krishnamoorthy, R. R. Tags: Glaucoma Source Type: research
Choroidal Thickness in Geographic Atrophy Secondary to Age-Related Macular Degeneration [Retina]
Conclusions.
The results indicate that the choroid in eyes with GA is thinner compared to normal eyes of similar age. Hereby, the extent of thinning is most pronounced in a specific subtype of GA identified by FAF imaging ("diffuse trickling"). Such GA subtype–related differences in choroidal thickness may reflect heterogeneity in the pathogenesis of disease. (ClinicalTrials.gov number, NCT02051998.) (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - February 9, 2015 Category: Opthalmology Authors: Lindner, M., Bezatis, A., Czauderna, J., Becker, E., Brinkmann, C. K., Schmitz-Valckenberg, S., Fimmers, R., Holz, F. G., Fleckenstein, M. Tags: Retina Source Type: research
Networks of Genes Governing the Development of Optic and Otic Vesicles: Implications for Eye and Ear Development [Research Highlight]
(Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - February 5, 2015 Category: Opthalmology Authors: Abitbol, M. M. Tags: Research Highlight Source Type: research
Abrogation of HMX1 Function Causes Rare Oculoauricular Syndrome Associated With Congenital Cataract, Anterior Segment Dysgenesis, and Retinal Dystrophy [Genetics]
Conclusions.
Oculoauricular syndrome is an autosomal recessive condition that has a profound effect on the development of the external ear, anterior segment, and retina, leading to significant visual loss at an early age. This study has delineated the phenotype and confirmed HMX1 as the gene causative of OAS, enabling the description of only the second family with the condition. HMX1 is a key player in ocular development, possibly in both the pathway responsible for lens and retina development, and via the gene network integral to optic fissure closure. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - February 5, 2015 Category: Opthalmology Authors: Gillespie, R. L., Urquhart, J., Lovell, S. C., Biswas, S., Parry, N. R. A., Schorderet, D. F., Lloyd, I. C., Clayton-Smith, J., Black, G. C. Tags: Genetics Source Type: research
Lamina Cribrosa Visibility Using Optical Coherence Tomography: Comparison of Devices and Effects of Image Enhancement Techniques [Glaucoma]
Conclusions.
Adaptive compensation is superior to EDI in improving LC visibility. Visibility of the posterior LC remains poor suggesting impracticality in using LC thickness as a glaucoma biomarker. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - February 5, 2015 Category: Opthalmology Authors: Girard, M. J. A., Tun, T. A., Husain, R., Acharyya, S., Haaland, B. A., Wei, X., Mari, J. M., Perera, S. A., Baskaran, M., Aung, T., Strouthidis, N. G. Tags: Glaucoma Source Type: research
Angiotensin II as a Morphogenic Cytokine Stimulating Fibrogenesis of Human Tenon's Capsule Fibroblasts [Glaucoma]
Conclusions.
Our results show that trabeculectomy alter the levels of Ang II and its receptors in Tenon's capsule fibroblasts, and that Ang II increase HTFs proliferation, migration, and phenotype transition, suggesting that Ang II may play a role in wound healing after trabeculectomy. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - February 5, 2015 Category: Opthalmology Authors: Shi, H., Zhang, Y., Fu, S., Lu, Z., Ye, W., Xiao, Y. Tags: Glaucoma Source Type: research
Major Depressive and Anxiety Disorders in Visually Impaired Older Adults [Low Vision]
Conclusions.
This study shows that depression and anxiety are major public health problems in visually impaired older adults. Research on psychotherapeutic and psychopharmacologic interventions to improve depression and anxiety in this population is warranted. (http://www.trialregister.nl number, NTR3296.) (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - February 5, 2015 Category: Opthalmology Authors: van der Aa, H. P. A., Comijs, H. C., Penninx, B. W. J. H., van Rens, G. H. M. B., van Nispen, R. M. A. Tags: Low Vision Source Type: research
The Association of Longitudinal Trend of Fasting Plasma Glucose With Retinal Microvasculature in People Without Established Diabetes [Clinical and Epidemiologic Research]
Conclusions.
Annual rising trend in FPG, but not its mean level or fluctuation, is associated with altered retinal vasculature in nondiabetic people. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - February 5, 2015 Category: Opthalmology Authors: Hu, Y., Niu, Y., Wang, D., Wang, Y., Holden, B. A., He, M. Tags: Clinical and Epidemiologic Research Source Type: research
Infrared Imaging of Meibomian Glands and Evaluation of the Lipid Layer in Sjogren's Syndrome Patients and Nondry Eye Controls [Cornea]
Conclusions.
Patients with SS showed higher meibomian gland dropout scores and reduced LLT and NITBUT, which likely contribute to the severe dry eye symptoms reported by SS subjects. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - February 5, 2015 Category: Opthalmology Authors: Menzies, K. L., Srinivasan, S., Prokopich, C. L., Jones, L. Tags: Cornea Source Type: research
