Heritability of Corneal Shape in Twin Study [Research Highlight]
(Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - December 23, 2014 Category: Opthalmology Authors: Ambrosio, R. Tags: Research Highlight Source Type: research
High Heritability of Posterior Corneal Tomography, as Measured by Scheimpflug Imaging, in a Twin Study [Clinical and Epidemiologic Research]
Conclusions.
This is the first study to explore heritability of a number of different parameters of corneal tomography, including posterior curvature. Almost all parameters appeared highly heritable, with a trend toward higher heritability estimates for posterior (versus anterior) parameters. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - December 23, 2014 Category: Opthalmology Authors: Mahroo, O. A., Oomerjee, M., Williams, K. M., O'Brart, D. P. S., Hammond, C. J. Tags: Clinical and Epidemiologic Research Source Type: research
Comparison of Kang's and Littmann's Methods of Correction for Ocular Magnification in Circumpapillary Retinal Nerve Fiber Layer Measurement [Glaucoma]
Conclusion.
No difference was found between Kang's and Littmann's methods for correction of ocular magnification in global cpRNFL thickness measurement. However, with regard to magnification correction for sectoral cpRNFL thickness, further scrutiny of Kang's method is warranted, even in healthy participants, because of the high variability between Littmann's and Kang's methods. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - December 23, 2014 Category: Opthalmology Authors: Hirasawa, K., Shoji, N., Yoshii, Y., Haraguchi, S. Tags: Glaucoma Source Type: research
Author Response: Interleukin-18 Bioactivity and Dose: Data Interpretation at a Crossroads [Letters]
(Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - December 23, 2014 Category: Opthalmology Authors: Kaneko, H. Tags: Letters Source Type: research
Interleukin-18 Bioactivity and Dose: Data Interpretation at a Crossroads [Letters]
(Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - December 23, 2014 Category: Opthalmology Authors: Doyle, S. L., Adamson, P., Lopez, F. J., Humphries, P., Campbell, M. Tags: Letters Source Type: research
Diagnostic Ability of Macular Nerve Fiber Layer Thickness Using New Segmentation Software in Glaucoma Suspects [Glaucoma]
Conclusions.
Macular RNFL thickness measurements showed an improved diagnostic capacity over the other variables examined to distinguish between healthy subjects and glaucoma suspects. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - December 23, 2014 Category: Opthalmology Authors: Martinez-de-la-Casa, J. M., Cifuentes-Canorea, P., Berrozpe, C., Sastre, M., Polo, V., Moreno-Montanes, J., Garcia-Feijoo, J. Tags: Glaucoma Source Type: research
Delayed Vision Loss and Therapeutic Intervention After Blast Injury [Research Highlight]
(Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - December 18, 2014 Category: Opthalmology Authors: Rex, T. S. Tags: Research Highlight Source Type: research
Early Detection of Subclinical Visual Damage After Blast-Mediated TBI Enables Prevention of Chronic Visual Deficit by Treatment With P7C3-S243 [Retina]
Conclusions.
Provocative PERG testing serves as a noninvasive test in the living organism to identify early damage to the visual system, which may reflect corresponding damage in the brain that is not otherwise detectable by noninvasive means. This provides the basis for developing an earlier diagnostic test to identify patients at risk for developing chronic CNS and visual system damage after TBI at an earlier stage when treatments may be more effective in preventing these sequelae. In addition, treatment with the neuroprotective agent P7C3-S243 after TBI protects from visual system dysfunction after TBI. (Source: Investi...
Source: Investigative Ophthalmology - December 18, 2014 Category: Opthalmology Authors: Dutca, L. M., Stasheff, S. F., Hedberg-Buenz, A., Rudd, D. S., Batra, N., Blodi, F. R., Yorek, M. S., Yin, T., Shankar, M., Herlein, J. A., Naidoo, J., Morlock, L., Williams, N., Kardon, R. H., Anderson, M. G., Pieper, A. A., Harper, M. M. Tags: Retina Source Type: research
ATP-Induced Photoreceptor Death in a Feline Model of Retinal Degeneration [Retinal Cell Biology]
Conclusions.
Development of an ATP-induced feline model of retinal degeneration provides a rapid and effective large-eyed animal model for research into vision restoration. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - December 18, 2014 Category: Opthalmology Authors: Aplin, F. P., Luu, C. D., Vessey, K. A., Guymer, R. H., Shepherd, R. K., Fletcher, E. L. Tags: Retinal Cell Biology Source Type: research
Objective Evaluation of the Degree of Pigmentation in Human Induced Pluripotent Stem Cell-Derived RPE [Retinal Cell Biology]
Conclusions.
The lightness of the HSL color space can be used to objectively and quantitatively evaluate the dPG of hiPSC-RPE in culture. The objective evaluation was consistent and was able to better identify small differences than subjective evaluation. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - December 18, 2014 Category: Opthalmology Authors: Kamao, H., Mandai, M., Wakamiya, S., Ishida, J., Goto, K., Ono, T., Suda, T., Takahashi, M., Kiryu, J. Tags: Retinal Cell Biology Source Type: research
Reappraisal of Geographic Atrophy Patterns Seen on Fundus Autofluorescence Using a Latent Class Analysis Approach [Clinical and Epidemiologic Research]
Conclusions.
The original description of FAF patterns, which is based exclusively on distribution of hyperautofluorescence around GA, ultimately classifies patients according to area of atrophy. These results suggest that FAF patterns are not true phenotypes and that they rather represent different stages of the disease. This may have implications regarding the role of lipofuscin on disease pathogenesis.
Spanish Abstract (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - December 18, 2014 Category: Opthalmology Authors: Biarnes, M., Forero, C. G., Arias, L., Alonso, J., Mones, J. Tags: Clinical and Epidemiologic Research Source Type: research
Role of {alpha}1-Adrenoceptor Subtypes in Pupil Dilation Studied With Gene-Targeted Mice [Physiology and Pharmacology]
Conclusions.
The α1-AR–induced mydriasis in mice is mediated mainly by the α1A-AR, with a smaller contribution of the α1B-AR, matching the relative abundance of these subtypes at the mRNA level. The lack of a single α1-AR subtype does not appear to cause atrophy in the mouse iris. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - December 18, 2014 Category: Opthalmology Authors: Kordasz, M. L., Manicam, C., Steege, A., Goloborodko, E., Amato, C., Laspas, P., Brochhausen, C., Pfeiffer, N., Gericke, A. Tags: Physiology and Pharmacology Source Type: research
Instantaneous Flow Rate of Vitreous Cutter Probes [Retina]
Conclusions.
Cutter blade action determines instantaneous flow rate fluctuation that interferes significantly with cutter suction and hampers a steady suction through cutter port. In a surgical scenario, this translates into a higher risk of inadvertent retinal entrapment and lower predictability of cutter behavior, especially at frequency approaching resonance. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - December 18, 2014 Category: Opthalmology Authors: Rossi, T., Querzoli, G., Angelini, G., Rossi, A., Malvasi, C., Iossa, M., Ripandelli, G. Tags: Retina Source Type: research
Damage to the Immature Optic Radiation Causes Severe Reduction of the Retinal Nerve Fiber Layer, Resulting in Predictable Visual Field Defects [Eye Movements, Strabismus, Amblyopia, and Neuro-Ophthalmology]
Conclusions.
Primary injuries in the immature OR are associated with reduced RNFL thickness, and examination of the RNFL may be a helpful predictor of VF defects. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - December 18, 2014 Category: Opthalmology Authors: Lennartsson, F., Nilsson, M., Flodmark, O., Jacobson, L. Tags: Eye Movements, Strabismus, Amblyopia, and Neuro-Ophthalmology Source Type: research
Endothelial TWIST1 Promotes Pathological Ocular Angiogenesis [Retinal Cell Biology]
Conclusions.
Our study suggests that TWIST1 is a novel regulator of pathologic ocular angiogenesis and may represent a new molecular target for developing potential therapeutic treatments to suppress pathological neovascularization in vascular eye diseases. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - December 18, 2014 Category: Opthalmology Authors: Li, J., Liu, C.-H., Sun, Y., Gong, Y., Fu, Z., Evans, L. P., Tian, K. T., Juan, A. M., Hurst, C. G., Mammoto, A., Chen, J. Tags: Retinal Cell Biology Source Type: research
