Role of {alpha}1-Adrenoceptor Subtypes in Pupil Dilation Studied With Gene-Targeted Mice [Physiology and Pharmacology]

Conclusions.
The α1-AR–induced mydriasis in mice is mediated mainly by the α1A-AR, with a smaller contribution of the α1B-AR, matching the relative abundance of these subtypes at the mRNA level. The lack of a single α1-AR subtype does not appear to cause atrophy in the mouse iris.

Source: Investigative Ophthalmology - December 18, 2014 Category: Opthalmology Authors: Kordasz, M. L., Manicam, C., Steege, A., Goloborodko, E., Amato, C., Laspas, P., Brochhausen, C., Pfeiffer, N., Gericke, A. Tags: Physiology and Pharmacology Source Type: research