Correlations Among Near-Infrared and Short-Wavelength Autofluorescence and Spectral-Domain Optical Coherence Tomography in Recessive Stargardt Disease [Retina]
Conclusions.
Lesion areas were more completely delineated in NIR-AF images than with SW-AF. In most cases, EZ loss was observed only at locations where NIR-AF was reduced or absent, indicating that RPE cell atrophy occurs in advance of photoreceptor cell degeneration. Because SW-AF was often increased within the central area of EZ disruption, degenerating photoreceptor cells may produce lipofuscin at accelerated levels. Consideration is given to mechanisms underlying hyper–NIR-AF in conjunction with increased SW-AF. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - December 12, 2014 Category: Opthalmology Authors: Duncker, T., Marsiglia, M., Lee, W., Zernant, J., Tsang, S. H., Allikmets, R., Greenstein, V. C., Sparrow, J. R. Tags: Retina Source Type: research
Variation of Laminar Depth in Normal Eyes With Age and Race [Glaucoma]
Conclusions.
With increasing age, the LD changes differently across racial groups in normal subjects. The LD in ED subjects showed a significantly decreasing slope suggesting that the lamina moves anteriorly with age in this group. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - December 12, 2014 Category: Opthalmology Authors: Rhodes, L. A., Huisingh, C., Johnstone, J., Fazio, M., Smith, B., Clark, M., Downs, J. C., Owsley, C., Girard, M. J. A., Mari, J. M., Girkin, C. Tags: Glaucoma Source Type: research
Benzalkonium Chloride Induces Subconjunctival Fibrosis Through the COX-2-Modulated Activation of a TGF-{beta}1/Smad3 Signaling Pathway [Anatomy and Pathology/Oncology]
Conclusions.
Subconjunctival fibrosis BAC-induced is a consequence of excessive ECM production of CFs through the COX-2–modulated activation of a TGF-β1/Smad3 signaling pathway. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - December 12, 2014 Category: Opthalmology Authors: Huang, C., Wang, H., Pan, J., Zhou, D., Chen, W., Li, W., Chen, Y., Liu, Z. Tags: Anatomy and Pathology/Oncology Source Type: research
Automated Measurement of Resolution Acuity in Infants Using Remote Eye-Tracking [Visual Psychophysics and Physiological Optics]
Conclusions.
An adaptive computerized test of infant vision using eye-tracking provides a rapid, automated measure of resolution acuity in preverbal infants. The ACTIVE performed comparably to the current clinical gold standard (acuity cards) in terms of testability, reliability, and accuracy, and its principles can be extended to measure other visual functions. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - December 12, 2014 Category: Opthalmology Authors: Jones, P. R., Kalwarowsky, S., Atkinson, J., Braddick, O. J., Nardini, M. Tags: Visual Psychophysics and Physiological Optics Source Type: research
Pathogenic Mitochondrial DNA Mutations and Associated Clinical Features in Korean Patients With Leber's Hereditary Optic Neuropathy [Genetics]
Conclusions.
In addition to common primary LHON-associated mutations, our study identified secondary mtDNA mutations, which should be considered when evaluating patients with optic atrophy. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - December 12, 2014 Category: Opthalmology Authors: Yum, H. R., Chae, H., Shin, S. Y., Kim, Y., Kim, M., Park, S. H. Tags: Genetics Source Type: research
Prediction Accuracy of a Novel Dynamic Structure-Function Model for Glaucoma Progression [Glaucoma]
Conclusions.
The two models had similar prediction capabilities, and the DSF model performed better in shorter time series. The DSF model could be clinically useful when only limited follow-ups are available. (ClinicalTrials.gov numbers, NCT00221923, NCT00221897.) (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - December 12, 2014 Category: Opthalmology Authors: Hu, R., Marin-Franch, I., Racette, L. Tags: Glaucoma Source Type: research
Virtual Electrodes by Current Steering in Retinal Prostheses [Retina]
Conclusions.
These results suggest that current steering can alter activation patterns in the visual cortex and could enhance visual perception in retinal implants by eliciting phosphene percepts intermediate between those elicited by physical electrodes. These results inform development of new electrode arrays that can take advantage of current steering. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - December 12, 2014 Category: Opthalmology Authors: Dumm, G., Fallon, J. B., Williams, C. E., Shivdasani, M. N. Tags: Retina Source Type: research
Shear Stress-Triggered Nitric Oxide Release From Schlemm's Canal Cells [Physiology and Pharmacology]
Conclusions.
Shear stress triggers NO production in human SC cells, similar to other vascular endothelia. Increased shear stress and NO production during SC collapse at elevated intraocular pressures may in part mediate IOP homeostasis. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - December 12, 2014 Category: Opthalmology Authors: Ashpole, N. E., Overby, D. R., Ethier, C. R., Stamer, W. D. Tags: Physiology and Pharmacology Source Type: research
Assessment of Perfused Foveal Microvascular Density and Identification of Nonperfused Capillaries in Healthy and Vasculopathic Eyes [Multidisciplinary Ophthalmic Imaging]
Conclusions.
AOSLO FA provides an in vivo method for estimating foveal microvascular density and reveals occult nonperfused retinal capillaries. Nonperfused capillaries in healthy young adults may represent a normal variation and/or an early sign of pathology. Although limited, the normative data presented here is a step toward developing clinically useful microvascular parameters for ocular and/or systemic diseases. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - December 12, 2014 Category: Opthalmology Authors: Pinhas, A., Razeen, M., Dubow, M., Gan, A., Chui, T. Y., Shah, N., Mehta, M., Gentile, R. C., Weitz, R., Walsh, J. B., Sulai, Y. N., Carroll, J., Dubra, A., Rosen, R. B. Tags: Multidisciplinary Ophthalmic Imaging Source Type: research
Erratum [Erratum]
(Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - December 10, 2014 Category: Opthalmology Tags: Erratum Source Type: research
Targeting Endostatin to Potentially Prevent Retinal Neovascularization Using a Hypoxia-Responsive Muller Glia Cell-Specific Gene Therapy [Research Highlight]
(Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - December 10, 2014 Category: Opthalmology Authors: Craft, C. M. Tags: Research Highlight Source Type: research
A Hypoxia-Responsive Glial Cell-Specific Gene Therapy Vector for Targeting Retinal Neovascularization [Retinal Cell Biology]
Conclusions.
These findings suggest that the hypoxia-regulated, glial cell–specific vector expressing endostatin may be useful for treatment of neovascularization in proliferative diabetic retinopathy. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - December 10, 2014 Category: Opthalmology Authors: Biswal, M. R., Prentice, H. M., Dorey, C. K., Blanks, J. C. Tags: Retinal Cell Biology Source Type: research
Mutations in the ABCA3 Gene Are Associated With Cataract-Microcornea Syndrome [Genetics]
Conclusions.
Mutations in the human ABCA3 gene were associated with lethal respiratory distress. Our study showed, for the first time to our knowledge, that mutations in ABCA3 were associated with CCMC, warranting further investigations on the pathogenesis of this disorder. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - December 10, 2014 Category: Opthalmology Authors: Chen, P., Dai, Y., Wu, X., Wang, Y., Sun, S., Xiao, J., Zhang, Q., Guan, L., Zhao, X., Hao, X., Wu, R., Xie, L. Tags: Genetics Source Type: research
Additive Diagnostic Role of Imaging in Glaucoma: Optical Coherence Tomography and Retinal Nerve Fiber Layer Photography [Glaucoma]
Conclusions.
In contrast to RNFLP, SD-OCT did not significantly enhance the diagnostic accuracy of detecting glaucoma or even of preperimetric glaucoma. Our results suggest that, at least for glaucoma specialists, the additive diagnostic role of OCT is limited. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - December 10, 2014 Category: Opthalmology Authors: Kim, K. E., Kim, S. H., Oh, S., Jeoung, J. W., Suh, M. H., Seo, J. H., Kim, M., Park, K. H., Kim, D. M. Tags: Glaucoma Source Type: research
Simulated Hyperopic Anisometropia and Reading, Visual Information Processing, and Reading-Related Eye Movement Performance in Children [Visual Psychophysics and Physiological Optics]
Conclusions.
Simulated hyperopic anisometropia significantly impaired academic-related performance, particularly in combination with sustained near work. The impact of uncorrected habitual anisometropia on academic-related performance in children requires further investigation. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - December 10, 2014 Category: Opthalmology Authors: Narayanasamy, S., Vincent, S. J., Sampson, G. P., Wood, J. M. Tags: Visual Psychophysics and Physiological Optics Source Type: research
