Benzalkonium Chloride Induces Subconjunctival Fibrosis Through the COX-2-Modulated Activation of a TGF-{beta}1/Smad3 Signaling Pathway [Anatomy and Pathology/Oncology]

Conclusions.
Subconjunctival fibrosis BAC-induced is a consequence of excessive ECM production of CFs through the COX-2–modulated activation of a TGF-β1/Smad3 signaling pathway.

Source: Investigative Ophthalmology - December 12, 2014 Category: Opthalmology Authors: Huang, C., Wang, H., Pan, J., Zhou, D., Chen, W., Li, W., Chen, Y., Liu, Z. Tags: Anatomy and Pathology/Oncology Source Type: research