Correlations Among Near-Infrared and Short-Wavelength Autofluorescence and Spectral-Domain Optical Coherence Tomography in Recessive Stargardt Disease [Retina]

Conclusions.
Lesion areas were more completely delineated in NIR-AF images than with SW-AF. In most cases, EZ loss was observed only at locations where NIR-AF was reduced or absent, indicating that RPE cell atrophy occurs in advance of photoreceptor cell degeneration. Because SW-AF was often increased within the central area of EZ disruption, degenerating photoreceptor cells may produce lipofuscin at accelerated levels. Consideration is given to mechanisms underlying hyper–NIR-AF in conjunction with increased SW-AF.

Source: Investigative Ophthalmology - December 12, 2014 Category: Opthalmology Authors: Duncker, T., Marsiglia, M., Lee, W., Zernant, J., Tsang, S. H., Allikmets, R., Greenstein, V. C., Sparrow, J. R. Tags: Retina Source Type: research