Torsion of the Optic Nerve Head Is a Prominent Feature of Normal-Tension Glaucoma [Glaucoma]
Conclusions.
Normal-tension glaucoma eyes had a greater ONH torsion compared to POAG eyes with matched axial length. The direction of the ONH tilt and torsion was related to the location of the visual field defect only in NTG eyes. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - January 9, 2015 Category: Opthalmology Authors: Park, H.-Y. L., Lee, K.-I., Lee, K., Shin, H. Y., Park, C. K. Tags: Glaucoma Source Type: research
A Homozygous Missense Mutation in NEUROD1 Is Associated With Nonsyndromic Autosomal Recessive Retinitis Pigmentosa [Genetics]
Conclusions.
We identified a potential novel genotype–phenotype correlation between NEUROD1 and nonsyndromic ARRP. Our study supports the idea that NEUROD1 is important for maintenance of the retina function and partial loss-of-function mutation in NEUROD1 is likely a rare cause of nonsyndromic ARRP. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - January 9, 2015 Category: Opthalmology Authors: Wang, F., Li, H., Xu, M., Li, H., Zhao, L., Yang, L., Zaneveld, J. E., Wang, K., Li, Y., Sui, R., Chen, R. Tags: Genetics Source Type: research
The Effect of Bangerter Filters on Binocular Function in Observers With Amblyopia [Visual Psychophysics and Physiological Optics]
Conclusions.
Bangerter filters can immediately reduce suppression and promote binocular summation for mid/low spatial frequencies in observers with amblyopia. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - January 6, 2015 Category: Opthalmology Authors: Chen, Z., Li, J., Thompson, B., Deng, D., Yuan, J., Chan, L., Hess, R. F., Yu, M. Tags: Visual Psychophysics and Physiological Optics Source Type: research
The Driving Visual Field and a History of Motor Vehicle Collision Involvement in Older Drivers: A Population-Based Examination [Low Vision]
Conclusions.
Results suggest that older drivers with severe impairment in the lower or left region of the driving visual field are more likely to have a history of at-fault collision involvement. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - January 6, 2015 Category: Opthalmology Authors: Huisingh, C., McGwin, G., Wood, J., Owsley, C. Tags: Low Vision Source Type: research
Functional Evaluation Using Multifocal Electroretinogram After Selective Retina Therapy With a Microsecond-Pulsed Laser [Retina]
Conclusions.
The results suggest that SRT preserved retinal function as well as anatomical structure after treatment. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - January 6, 2015 Category: Opthalmology Authors: Kim, H. D., Han, J. W., Ohn, Y.-H., Brinkmann, R., Park, T. K. Tags: Retina Source Type: research
Microperimetry of Nascent Geographic Atrophy in Age-Related Macular Degeneration [Retina]
Conclusions.
Areas of nGA were characterized by worse microperimetric retinal sensitivity compared with nonatrophic areas in eyes with intermediate AMD, but better retinal sensitivity compared with areas of drusen-associated atrophy detected on SD-OCT. Areas of nGA were also not always the worst performing point in an eye. These findings further our understanding of the functional changes occurring in novel SD-OCT identified pathological changes in intermediate AMD. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - January 6, 2015 Category: Opthalmology Authors: Wu, Z., Ayton, L. N., Luu, C. D., Guymer, R. H. Tags: Retina Source Type: research
Cone Responses in Usher Syndrome Types 1 and 2 by Microvolt Electroretinography [Retina]
Conclusions.
Cycle-by-cycle ERG showed progressive loss of amplitude in both USH1 and USH2 subjects, comparable to that reported with psychophysical measures. Usher subjects showed abnormal ERG response latency, but this changed less than amplitude with time. In USH syndrome, CxC ERG is more sensitive than conventional ERG and warrants consideration as an outcome measure in USH treatment trials. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - January 6, 2015 Category: Opthalmology Authors: Zein, W. M., Falsini, B., Tsilou, E. T., Turriff, A. E., Schultz, J. M., Friedman, T. B., Brewer, C. C., Zalewski, C. K., King, K. A., Muskett, J. A., Rehman, A. U., Morell, R. J., Griffith, A. J., Sieving, P. A. Tags: Retina Source Type: research
Author Response: What to Do About Racial Disparities in Access to Glasses Among Children in the US? [Letters]
(Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - January 6, 2015 Category: Opthalmology Authors: Zadnik, K., Congdon, N. G. Tags: Letters Source Type: research
Ocular Higher-Order Wavefront Aberrations in the Japanese Adult Population: the Yamagata Study (Funagata) [Clinical and Epidemiologic Research]
Conclusions.
Aging is associated with increases in ocular HOAs, independent of other possible confounding factors. The association of ocular HOAs with corneal parameters indicates that ocular HOAs are mainly generated by the cornea. Internal HOAs, supposedly generated from cataract progression, may be associated with systemic factors, including serum creatinine levels and blood pressure. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - January 6, 2015 Category: Opthalmology Authors: Namba, H., Kawasaki, R., Narumi, M., Sugano, A., Homma, K., Nishi, K., Murakami, T., Kato, T., Kayama, T., Yamashita, H. Tags: Clinical and Epidemiologic Research Source Type: research
Intravitreal Autologous Bone Marrow CD34+ Cell Therapy for Ischemic and Degenerative Retinal Disorders: Preliminary Phase 1 Clinical Trial Findings [Clinical Trials]
Conclusions.
Intravitreal autologous BM CD34+ cell therapy appears feasible and well tolerated in eyes with ischemic or degenerative retinal conditions and merits further exploration. (ClinicalTrials.gov number, NCT01736059.) (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - January 6, 2015 Category: Opthalmology Authors: Park, S. S., Bauer, G., Abedi, M., Pontow, S., Panorgias, A., Jonnal, R., Zawadzki, R. J., Werner, J. S., Nolta, J. Tags: Clinical Trials Source Type: research
Involvement of the Receptor-Associated Prorenin System in the Pathogenesis of Human Conjunctival Lymphoma [Anatomy and Pathology/Oncology]
Conclusions.
The present study suggests that activation of (P)RR and AT1R is associated with the pathogenesis of conjunctival EMZL by stimulating the production of FGF2 and MMPs. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - January 6, 2015 Category: Opthalmology Authors: Ishizuka, E. T., Kanda, A., Kase, S., Noda, K., Ishida, S. Tags: Anatomy and Pathology/Oncology Source Type: research
Protective Effects of {beta}1/2 Adrenergic Receptor Deletion in a Model of Oxygen-Induced Retinopathy [Biochemistry and Molecular Biology]
Conclusions.
We confirm that β1- and β2-ARs play a pivotal role in retinal angiogenesis. In their presence, β3-ARs potentiate angiogenic responses, whereas, in their absence, β3-ARs sustain the angiogenic drive. These results suggest β-ARs as promising targets for therapies aimed to counteract proliferative retinopathies. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - January 6, 2015 Category: Opthalmology Authors: Dal Monte, M., Cammalleri, M., Mattei, E., Filippi, L., Bagnoli, P. Tags: Biochemistry and Molecular Biology Source Type: research
Long-term Tear Volume Changes After Blepharoptosis Surgery and Blepharoplasty [Cornea]
Conclusions.
Long-term tear volume was not changed after blepharoplasty but was decreased after blepharoptosis surgery, and even more so in cases with an initial high tear volume. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - January 6, 2015 Category: Opthalmology Authors: Watanabe, A., Selva, D., Kakizaki, H., Oka, Y., Yokoi, N., Wakimasu, K., Kimura, N., Kinoshita, S. Tags: Cornea Source Type: research
Effect of 0.025% FK-506 Eyedrops on Botulinum Toxin B-Induced Mouse Dry Eye [Cornea]
Conclusions.
Topical application of FK-506 can inhibit NF-B activation and related inflammatory response and alleviate the signs of dry eye. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - January 6, 2015 Category: Opthalmology Authors: Lin, B.-w., Chen, M.-z., Fan, S.-x., Chuck, R. S., Zhou, S.-y. Tags: Cornea Source Type: research
Inverse Relationship Between the Intraretinal Concentration of Bioavailable Nitric Oxide and Blood Glucose in Early Experimental Diabetic Retinopathy [Biochemistry and Molecular Biology]
Conclusions.
The higher-than-control level of NO in mild diabetic rats and lower-than-control level in severe diabetic rats show that severity of diabetes is an important factor when measuring the bioavailability of NO in diabetic retinopathy. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - January 6, 2015 Category: Opthalmology Authors: Guthrie, M. J., Osswald, C. R., Kang-Mieler, J. J. Tags: Biochemistry and Molecular Biology Source Type: research
