Efficacy of Intravitreal Injection of Aflibercept in Neovascular Age-Related Macular Degeneration With or Without Choroidal Vascular Hyperpermeability [Retina]
Conclusions.
Intravitreal aflibercept can achieve remission of exudative retinal changes in eyes with AMD even in the presence of CVH. In addition, it showed greater effects on the choroid and PED than intravitreal ranibizumab. The possible relationship between CVH suppression and decrease in CT warrants further study. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - December 9, 2014 Category: Opthalmology Authors: Hata, M., Oishi, A., Tsujikawa, A., Yamashiro, K., Miyake, M., Ooto, S., Tamura, H., Nakanishi, H., Takahashi, A., Yoshikawa, M., Yoshimura, N. Tags: Retina Source Type: research
O-GlcNAc Modification of Transcription Factor Sp1 Mediates Hyperglycemia-Induced VEGF-A Upregulation in Retinal Cells [Biochemistry and Molecular Biology]
Conclusions.
Hyperglycemia-driven VEGF-A production is mediated by elevated O-GlcNAc modification of the Sp1 transcription factor. This mechanism may be significant in the pathogenesis of preclinical DR through VEGF-A upregulation. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - December 9, 2014 Category: Opthalmology Authors: Donovan, K., Alekseev, O., Qi, X., Cho, W., Azizkhan-Clifford, J. Tags: Biochemistry and Molecular Biology Source Type: research
Differential Proteomic Analyses of Cataracts From Rat Models of Type 1 and 2 Diabetes [Lens]
Conclusions.
The results suggest that osmotic damage, GSH loss, and decreased ATP production might be important pathological mechanisms in T1DC formation, whereas crystallin modification and cross-linking/aggregation as well as IF degradation may play more crucial roles in T2DC formation. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - December 9, 2014 Category: Opthalmology Authors: Su, S., Leng, F., Guan, L., Zhang, L., Ge, J., Wang, C., Chen, S., Liu, P. Tags: Lens Source Type: research
Effects of Strabismic Amblyopia and Strabismus Without Amblyopia on Visuomotor Behavior: III. Temporal Eye-Hand Coordination During Reaching [Eye Movements, Strabismus, Amblyopia, and Neuro-Ophthalmology]
Conclusions.
Adults with strabismic amblyopia and strabismus only showed an altered pattern of temporal eye–hand coordination during the reach acceleration phase, which might affect their ability to modify reach trajectory using early online control. Secondary reach-related saccades may provide a compensatory mechanism with which to facilitate the late online control process in order to ensure relatively good reaching performance during binocular and fellow eye viewing. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - December 9, 2014 Category: Opthalmology Authors: Niechwiej-Szwedo, E., Goltz, H. C., Chandrakumar, M., Wong, A. M. F. Tags: Eye Movements, Strabismus, Amblyopia, and Neuro-Ophthalmology Source Type: research
Design and Characterization of an Ocular Topical Liposomal Preparation to Replenish the Lipids of the Tear Film [Nanotechnology and Regenerative Medicine]
Conclusions.
The unpreserved liposomal formulation has suitable properties to be administered by a topical ophthalmic route. The liposome-based artificial tear had good in vitro and in vivo tolerance responses. This formulation, composed of a combination of liposomes and bioadhesive polymers, may be used successfully as a tear film substitute in DE therapy. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - December 5, 2014 Category: Opthalmology Authors: Vicario-de-la-Torre, M., Benitez-del-Castillo, J. M., Vico, E., Guzman, M., de-las-Heras, B., Herrero-Vanrell, R., Molina-Martinez, I. T. Tags: Nanotechnology and Regenerative Medicine Source Type: research
Transcriptome Analysis of the Human Corneal Endothelium [Cornea]
Conclusions.
An analysis of the HCEnC transcriptome reveals the expression of almost 13,000 genes, with less than 1% mapped to chromosomal loci associated with PPCD1, FECD4, and XECD. At least nine genes demonstrated significant differential expression between pediatric and adult HCEnC, defining specific functional properties distinct to each age group. These data will serve as a resource for vision scientists investigating HCEnC gene expression and can be used to focus the search for the genetic basis of the corneal endothelial dystrophies for which the genetic basis remains unknown. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - December 5, 2014 Category: Opthalmology Authors: Frausto, R. F., Wang, C., Aldave, A. J. Tags: Cornea Source Type: research
Identifying "Preperimetric" Glaucoma in Standard Automated Perimetry Visual Fields [Glaucoma]
Conclusions.
Differences exist between healthy VFs and VFs of preperimetric glaucoma eyes, which go on to develop manifest glaucoma; these two groups of VFs could be well distinguished by using the Random Forests classifier. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - December 5, 2014 Category: Opthalmology Authors: Asaoka, R., Iwase, A., Hirasawa, K., Murata, H., Araie, M. Tags: Glaucoma Source Type: research
Visual Contrast Detection Cannot Be Predicted From Surrogate Measures of Retinal Ganglion Cell Number and Sampling Density in Healthy Young Adults [Visual Psychophysics and Physiological Optics]
Conclusions.
Despite considerable variation in both psychometric functions for contrast detection and surrogate measures of retinal ganglion cell number and sampling density among healthy eyes, relationships between these measures are weak. These relationships are unlikely to be exploitable for improving clinical tests in healthy populations. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - December 5, 2014 Category: Opthalmology Authors: Denniss, J., Turpin, A., McKendrick, A. M. Tags: Visual Psychophysics and Physiological Optics Source Type: research
Physical Activity and the 15-Year Incidence of Age-Related Macular Degeneration [Clinical and Epidemiologic Research]
Conclusions.
Physical activity did not influence the risk of AMD over 15 years in older adults, independent of diet, smoking, white cell count, and body mass index. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - December 3, 2014 Category: Opthalmology Authors: Gopinath, B., Liew, G., Burlutsky, G., Mitchell, P. Tags: Clinical and Epidemiologic Research Source Type: research
Regional Choroidal Blood Flow and Multifocal Electroretinography in Experimental Glaucoma in Rhesus Macaques [Glaucoma]
Conclusions.
This is the first demonstration of globally reduced ChBF in chronic experimental glaucoma in the nonhuman primate. Both the alteration of mfERG waveform components associated with outer retinal function and the reduction in ChBF were greatest in the macula, suggesting that there may be a spatial colocalization between ChBF and some outer retinal effects in glaucoma. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - December 3, 2014 Category: Opthalmology Authors: Nork, T. M., Kim, C. B. Y., Munsey, K. M., Dashek, R. J., Hoeve, J. N. V. Tags: Glaucoma Source Type: research
Retinal and Choroidal Changes With Severe Hypertension and Their Association With Visual Outcome [Retina]
Conclusions.
Severe hypertension resulted in exudative retinal and choroidal changes, characterized by SRF accumulation and increased SCT. Our grading system may represent retinopathy severity and predict visual outcome better than the KWB grading system in patients with severe hypertension. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - December 3, 2014 Category: Opthalmology Authors: Ahn, S. J., Woo, S. J., Park, K. H. Tags: Retina Source Type: research
Biological Features of Herpes Simplex Virus Type 1 Latency in Mice According to Experimental Conditions and Type of Neurones [Immunology and Microbiology]
Conclusions.
These results highlight that the behavior of the virus in the nervous system depends on the method inoculation, and the viral strain. All these parameters are likely to influence the establishment of latent infection. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - December 3, 2014 Category: Opthalmology Authors: Cavallero, S., Huot, N., Francelle, L., Lomonte, P., Naas, T., Labetoulle, M. Tags: Immunology and Microbiology Source Type: research
Foveal Contour Changes Following Surgery for Idiopathic Epiretinal Membrane [Retina]
Conclusions.
We developed a novel foveal contour grading method to assess retinal contour in ERM eyes before and after surgery. In eyes with ERM and no foveal depression, the majority did not regain foveal depression following surgery even though retinal thickness improved. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - December 3, 2014 Category: Opthalmology Authors: Mathews, N. R., Tarima, S., Kim, D.-G., Kim, J. E. Tags: Retina Source Type: research
LHON Gene Therapy Vector Prevents Visual Loss and Optic Neuropathy Induced by G11778A Mutant Mitochondrial DNA: Biodistribution and Toxicology Profile [Eye Movements, Strabismus, Amblyopia, and Neuro-Ophthalmology]
Conclusions.
Allotopically expressed wild-type ND4 prevents the phenotype induced by G11778A mitochondrial DNA with a toxicology profile acceptable for testing in a phase I clinical trial. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - December 1, 2014 Category: Opthalmology Authors: Koilkonda, R., Yu, H., Talla, V., Porciatti, V., Feuer, W. J., Hauswirth, W. W., Chiodo, V., Erger, K. E., Boye, S. L., Lewin, A. S., Conlon, T. J., Renner, L., Neuringer, M., Detrisac, C., Guy, J. Tags: Eye Movements, Strabismus, Amblyopia, and Neuro-Ophthalmology Source Type: research
Spatiotemporal Interactions in the Visual Cortex Following Paired Electrical Stimulation of the Retina [Retina]
Conclusions.
Interactions between sequential stimulation of pairs of electrodes in a suprachoroidal retinal prosthesis occur for delays up to 100 ms and electrode separations of several millimeters. Knowledge of these spatiotemporal interactions is essential for developing effective patterns of stimulation for retinal prostheses. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - December 1, 2014 Category: Opthalmology Authors: Cicione, R., Fallon, J. B., Rathbone, G. D., Williams, C. E., Shivdasani, M. N. Tags: Retina Source Type: research
