Assessing Age-Related Changes in the Biomechanical Properties of Rabbit Lens Using a Coaligned Ultrasound and Optical Coherence Elastography System [Lens]
Conclusions.
The results demonstrate that the US-OCE system can be used for noninvasive analysis and quantification of lens biomechanical properties in situ and possibly in vivo. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - February 23, 2015 Category: Opthalmology Authors: Wu, C., Han, Z., Wang, S., Li, J., Singh, M., Liu, C.-h., Aglyamov, S., Emelianov, S., Manns, F., Larin, K. V. Tags: Lens Source Type: research
Factors Influencing the Output of Rural Cataract Surgical Facilities in China: The SHARP Study [Clinical and Epidemiologic Research]
Conclusions.
Outreach cataract screening was the strongest predictor of increased surgical output. Government and INGDO investment in screening may be most likely to enhance output of county hospitals, a major goal of China's Blindness Prevention Plan. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - February 23, 2015 Category: Opthalmology Authors: Chen, T., Jin, L., Zhou, Z., Huang, Y., Yan, X., Liu, T., Ong, E. L., Liu, B., Huang, W., Iezzi, B., He, M., Friedman, D. S., Congdon, N. G. Tags: Clinical and Epidemiologic Research Source Type: research
Cosmetic Preservatives as Therapeutic Corneal and Scleral Tissue Cross-Linking Agents [Cornea]
Conclusions.
The FARs, a class of compounds well known to the cosmetic industry, may have utility as therapeutic TXL agents. The compounds studied thus far show promise and will be further tested. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - February 23, 2015 Category: Opthalmology Authors: Babar, N., Kim, M., Cao, K., Shimizu, Y., Kim, S.-Y., Takaoka, A., Trokel, S. L., Paik, D. C. Tags: Cornea Source Type: research
Test-Retest Reliability of Hemifield, Central-Field, and Full-Field Chromatic Pupillometry for Assessing the Function of Melanopsin-Containing Retinal Ganglion Cells [Visual Neuroscience]
Conclusions.
We validated a new and repeatable method to measure PIPR induced by hemifield, central-field, and full-field light stimulation. Good PIPR measurement reliability was obtained under all conditions. This practical and reliable protocol will facilitate the clinical application of PIPR testing in different disease populations. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - February 23, 2015 Category: Opthalmology Authors: Lei, S., Goltz, H. C., Chandrakumar, M., Wong, A. M. F. Tags: Visual Neuroscience Source Type: research
RGS6: A Novel Gene Associated With Congenital Cataract, Mental Retardation, and Microcephaly in a Tunisian Family [Genetics]
Conclusions.
Our study identified a new gene to be included in the large spectrum of cataract-associated genes. Importantly, the study demonstrated that, in addition to lens-enriched genes that exhibit high expression levels, genes identified by iSyTE that are highly lens-enriched but have lower absolute expression may also represent candidates for potential function in the lens. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - February 19, 2015 Category: Opthalmology Authors: Chograni, M., Alkuraya, F. S., Maazoul, F., Lariani, I., Chaabouni-Bouhamed, H. Tags: Genetics Source Type: research
Agreement Among Spectral-Domain Optical Coherence Tomography, Standard Automated Perimetry, and Stereophotography in the Detection of Glaucoma Progression [Glaucoma]
Conclusions.
Methods obtained acceptable agreement outcomes in terms of PABAK, AC1, and OPA. However, most cases with detectable changes were identified only by one examination method, resulting in low Ppos. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - February 19, 2015 Category: Opthalmology Authors: Banegas, S. A., Anton, A., Morilla-Grasa, A., Bogado, M., Ayala, E. M., Moreno-Montanes, J. Tags: Glaucoma Source Type: research
Assessment of Retinal Function and Morphology in Aging Ccl2 Knockout Mice [Retinal Cell Biology]
Conclusions.
These data show that Ccl2 is important for preserving RPE and glial morphology with age, yet retinal function and gross morphology are maintained. Altered signaling in this chemokine pathway may, however, increase RPE and retinal vulnerability to disease. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - February 19, 2015 Category: Opthalmology Authors: Vessey, K. A., Waugh, M., Jobling, A. I., Phipps, J. A., Ho, T., Trogrlic, L., Greferath, U., Fletcher, E. L. Tags: Retinal Cell Biology Source Type: research
Understanding the Process of Corneal Endothelial Morphological Change In Vitro [Reviews]
Corneal endothelial cells often adopt a fibroblastic-like morphology in culture, a process that has been attributed to epithelial- or endothelial-to-mesenchymal transition (EMT or EndMT). Although being extensively studied in other cell types, this transition is less well characterized in the corneal endothelium. Because of their neuroectodermal origin and their in vivo mitotic arrest, corneal endothelial cells represent a particular tissue that deserves more attention. This review article presents the basic principles underlying EMT/EndMT, with emphasis on the current knowledge regarding the corneal endothelium. Furthermo...
Source: Investigative Ophthalmology - February 19, 2015 Category: Opthalmology Authors: Roy, O., Beaulieu Leclerc, V., Bourget, J.-M., Theriault, M., Proulx, S. Tags: Reviews Source Type: research
Calculation of Ophthalmic Viscoelastic Device-Induced Focus Shift During Femtosecond Laser-Assisted Cataract Surgery [Lens]
Conclusions.
Our calculations show that the change in refractive index due to anterior chamber refilling does not sufficiently shift the laser beam focus position to cause the incomplete capsulotomies reported during femtosecond laser–assisted cataract surgery. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - February 19, 2015 Category: Opthalmology Authors: de Freitas, C. P., Cabot, F., Manns, F., Culbertson, W., Yoo, S. H., Parel, J.-M. Tags: Lens Source Type: research
Age-Related Eye Disease and Cognitive Function [Clinical and Epidemiologic Research]
Conclusions.
People with vision loss due to three different age-related eye diseases had lower cognitive scores. Reasons for this should be explored using longitudinal studies and a full battery of cognitive tests that do not rely on vision. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - February 19, 2015 Category: Opthalmology Authors: Harrabi, H., Kergoat, M.-J., Rousseau, J., Boisjoly, H., Schmaltz, H., Moghadaszadeh, S., Roy-Gagnon, M.-H., Freeman, E. E. Tags: Clinical and Epidemiologic Research Source Type: research
Steady-State Contrast Response Functions Provide a Sensitive and Objective Index of Amblyopic Deficits [Eye Movements, Strabismus, Amblyopia, and Neuro-Ophthalmology]
Conclusions.
We suggest that SSVEPs offer a sensitive and objective measure of the ocular imbalance in amblyopia and could be used to assess the efficacy of amblyopia therapies currently under development. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - February 19, 2015 Category: Opthalmology Authors: Baker, D. H., Simard, M., Saint-Amour, D., Hess, R. F. Tags: Eye Movements, Strabismus, Amblyopia, and Neuro-Ophthalmology Source Type: research
Accommodative Performance of Children With Unilateral Amblyopia [Eye Movements, Strabismus, Amblyopia, and Neuro-Ophthalmology]
Conclusions.
When viewing monocularly, children with unilateral amblyopia had greater mean accommodative errors in their amblyopic eyes than in their nonamblyopic eyes, and when compared with control subjects. This could lead to unintended retinal image defocus during patching therapy for amblyopia. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - February 19, 2015 Category: Opthalmology Authors: Manh, V., Chen, A. M., Tarczy-Hornoch, K., Cotter, S. A., Candy, T. R. Tags: Eye Movements, Strabismus, Amblyopia, and Neuro-Ophthalmology Source Type: research
Two-Photon Fluorescence Microscopy of Corneal Riboflavin Absorption Through an Intact Epithelium [Letters]
(Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - February 19, 2015 Category: Opthalmology Authors: Gore, D. M., French, P., O'Brart, D., Dunsby, C., Allan, B. D. Tags: Letters Source Type: research
The -308G>A Polymorphism of the TNF Gene Is Associated With Proliferative Diabetic Retinopathy in Caucasian Brazilians With Type 2 Diabetes [Genetics]
Conclusions.
This study detected, for the first time to our knowledge, an independent association of the –308G>A polymorphism in the TNF gene with PDR in Caucasian Brazilians with type 2 diabetes. This finding suggests that TNF is a potential susceptibility gene for PDR. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - February 19, 2015 Category: Opthalmology Authors: Sesti, L. F. C., Crispim, D., Canani, L. H., Polina, E. R., Rheinheimer, J., Carvalho, P. S., Gross, J. L., Santos, K. G. Tags: Genetics Source Type: research
Author Response: PRIMPOL Mutation: Functional Study Does Not Always Reveal the Truth [Letters]
(Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - February 13, 2015 Category: Opthalmology Authors: Keen, B. A., Bailey, L. J., Jozwiakowski, S. K., Doherty, A. J. Tags: Letters Source Type: research
