The Prognostic Effect of American Joint Committee on Cancer Staging and Genetic Status in Patients With Choroidal and Ciliary Body Melanoma [Clinical and Epidemiologic Research]
Conclusions.
Identification of a normal genetic status of chromosomes 3 and 8 minimized the prognostic effect of AJCC staging, while a combination of genetic status and AJCC staging provided the most accurate prediction of survival in patients with an abnormal chromosomal status. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - January 15, 2015 Category: Opthalmology Authors: Bagger, M., Andersen, M. T., Andersen, K. K., Heegaard, S., Andersen, M. K., Kiilgaard, J. F. Tags: Clinical and Epidemiologic Research Source Type: research
Estimating the Critical Duration for Temporal Summation of Standard Achromatic Perimetric Stimuli [Glaucoma]
Conclusions.
Critical duration estimates in this study are substantially shorter than those previously reported for a Goldmann III stimulus, under the conditions of SAP. Further work is required to firmly establish the relationship between measurement variability and the degree of local temporal and spatial summation. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - January 15, 2015 Category: Opthalmology Authors: Mulholland, P. J., Redmond, T., Garway-Heath, D. F., Zlatkova, M. B., Anderson, R. S. Tags: Glaucoma Source Type: research
Whole Exome Sequencing Reveals GUCY2D as a Major Gene Associated With Cone and Cone-Rod Dystrophy in Israel [Genetics]
Conclusions.
Our study suggested that GUCY2D is a major cause of autosomal dominant cone and cone–rod dystrophies in Israel; this is similar to other Caucasian populations and is in contrast with retinitis pigmentosa (primary rod disease), where the genetic make-up of the Israeli population is distinct from other ethnic groups. We also conclude that WES permits more comprehensive and rapid analyses that can be followed by targeted screens of larger samples to delineate the genetic structure of retinal disease in unique population cohorts. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - January 15, 2015 Category: Opthalmology Authors: Lazar, C. H., Mutsuddi, M., Kimchi, A., Zelinger, L., Mizrahi-Meissonnier, L., Marks-Ohana, D., Boleda, A., Ratnapriya, R., Sharon, D., Swaroop, A., Banin, E. Tags: Genetics Source Type: research
Radiation Pretreatment Does Not Protect the Rat Optic Nerve From Elevated Intraocular Pressure-Induced Injury [Glaucoma]
Conclusions.
In contrast to previous observations in a mouse genetic glaucoma model, head-only irradiation offers the adult rat optic nerve no protection from optic nerve degeneration due to chronic, experimentally induced IOP elevation. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - January 15, 2015 Category: Opthalmology Authors: Johnson, E. C., Cepurna, W. O., Choi, D., Choe, T. E., Morrison, J. C. Tags: Glaucoma Source Type: research
Antioxidative Capacity of a Dietary Supplement on Retinal Hemodynamic Function in a Human Lipopolysaccharide (LPS) Model [Physiology and Pharmacology]
Conclusions.
The present data indicate restoring of the RBC flow response to 100% O2 after LPS administration. This is likely due to an amelioration of endothelial dysfunction resulting from oxidative stress, a factor involved in AMD pathophysiology. (ClinicalTrials.gov number, NCT00914576.) (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - January 15, 2015 Category: Opthalmology Authors: Told, R., Schmidl, D., Palkovits, S., Boltz, A., Gouya, G., Wolzt, M., Witkowska, K. J., Popa-Cherecheanu, A., Werkmeister, R. M., Garhofer, G., Schmetterer, L. Tags: Physiology and Pharmacology Source Type: research
Macular Retinal Ganglion Cell-Inner Plexiform Layer Thickness in Patients on Hydroxychloroquine Therapy [Retina]
Conclusions.
This study revealed that macular GC-IPL thickness did not show definite correlations with HCQ use. However, some patients, especially with HCQ retinopathy or high cumulative doses, showed thin GC-IPL. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - January 15, 2015 Category: Opthalmology Authors: Lee, M. G., Kim, S. J., Ham, D.-I., Kang, S. W., Kee, C., Lee, J., Cha, H.-S., Koh, E.-M. Tags: Retina Source Type: research
Baseline Characteristics of the Infant Aphakia Treatment Study Population: Predicting Recognition Acuity at 4.5 Years of Age [Clinical Trials]
Conclusions.
This analysis concurs with previous studies that early surgery is important for good visual outcomes in patients with unilateral infantile cataracts. The fact that only one baseline variable (private insurance) contributed to the multivariate analysis, accounting for 12% of the variance, suggests that predicting visual outcome for these patients is complicated at best, and cannot be estimated from baseline characteristics alone. (ClinicalTrials.gov number, NCT00212134.) (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - January 15, 2015 Category: Opthalmology Authors: Hartmann, E. E., Lynn, M. J., Lambert, S. R., for the Infant Aphakia Treatment Study Group Tags: Clinical Trials Source Type: research
Retinal Vascular Caliber, Iris Color, and Age-Related Macular Degeneration in the Irish Nun Eye Study [Retina]
Conclusions.
Retinal vascular caliber was not significantly associated with iris color or early/late AMD after adjustment for confounders. A lower but nonsignificant AMD risk was observed in those with brown compared to blue iris color. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - January 15, 2015 Category: Opthalmology Authors: McGowan, A., Silvestri, G., Moore, E., Silvestri, V., Patterson, C. C., Maxwell, A. P., McKay, G. J. Tags: Retina Source Type: research
Correlation of Outer Nuclear Layer Thickness With Cone Density Values in Patients With Retinitis Pigmentosa and Healthy Subjects [Multidisciplinary Ophthalmic Imaging]
Conclusions.
The ONL thickness and cone density were correlated in normal eyes and eyes with RP, but both were strongly correlated with retinal eccentricity, precluding estimation of cone density from ONL thickness. (ClinicalTrials.gov number, NCT00254605.) (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - January 15, 2015 Category: Opthalmology Authors: Menghini, M., Lujan, B. J., Zayit-Soudry, S., Syed, R., Porco, T. C., Bayabo, K., Carroll, J., Roorda, A., Duncan, J. L. Tags: Multidisciplinary Ophthalmic Imaging Source Type: research
Correlation of Pseudomonas aeruginosa Genotype With Antibiotic Susceptibility and Clinical Features of Induced Central Keratitis [Immunology and Microbiology]
Conclusions.
Cytotoxic strains are associated with contact lens wear while invasive strains are related to poor prognosis and increased resistance to fluoroquinolones. Clinicians should be aware of the two different genotypes of P. aeruginosa affecting prognosis. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - January 13, 2015 Category: Opthalmology Authors: Shen, E. P., Hsieh, Y.-T., Chu, H.-S., Chang, S.-C., Hu, F.-R. Tags: Immunology and Microbiology Source Type: research
The Effect of TIMP-1 on the Cone Mosaic in the Retina of the Rat Model of Retinitis Pigmentosa [Anatomy and Pathology/Oncology]
Conclusions.
These findings confirm that TIMP-1 induced M-cone mosaics in S334ter-line-3 to gain homogeneity without reaching the degree of regularity seen in normal retinal mosaics. Even if TIMP-1 fails to promote regularity, the effects of this drug on homogeneity appear to be so dramatic that TIMP-1 may be a potential therapeutic agent. TIMP-1 improves sampling of the visual field simply by causing homogeneity. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - January 13, 2015 Category: Opthalmology Authors: Ji, Y., Yu, W.-Q., Eom, Y. S., Bruce, F., Craft, C. M., Grzywacz, N. M., Lee, E.-J. Tags: Anatomy and Pathology/Oncology Source Type: research
Levels of Blood CD1c+ mDC1 and CD1chi mDC1 Subpopulation Reflect Disease Activity in Noninfectious Uveitis [Immunology and Microbiology]
Conclusions.
Given these observations, an alteration in blood CD1c+ mDC1 and the CD1chi mDC1 subpopulation could be a potential biomarker to monitor clinical uveitis activity within patients. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - January 13, 2015 Category: Opthalmology Authors: Chen, P., Tucker, W., Hannes, S., Liu, B., Si, H., Gupta, A., Lee, R. W. J., Sen, H. N., Nussenblatt, R. B. Tags: Immunology and Microbiology Source Type: research
Detection of Mutations in LRPAP1, CTSH, LEPREL1, ZNF644, SLC39A5, and SCO2 in 298 Families With Early-Onset High Myopia by Exome Sequencing [Genetics]
Conclusions.
Our results provide additional evidence to support the idea that mutation in LRPAP1 is associated with high myopia. Further studies are expected to evaluate the pathogenicity of the variants in CTSH, LEPREL1, ZNF644, SLC39A5, and SCO2. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - January 13, 2015 Category: Opthalmology Authors: Jiang, D., Li, J., Xiao, X., Li, S., Jia, X., Sun, W., Guo, X., Zhang, Q. Tags: Genetics Source Type: research
Intravitreal Sirolimus for the Treatment of Geographic Atrophy: Results of a Phase I/II Clinical Trial [Clinical Trials]
Conclusions.
While paralesional FAF changes and rapid retinal thinning observed are potentially part of the natural course of GA, they may possibly be related to treatment. No general evidence of anatomical or functional benefit was detected in treated eyes. Further data on intravitreal sirolimus for GA treatment will be available from a larger phase II trial. (ClinicalTrials.gov number, NCT01445548.) (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - January 13, 2015 Category: Opthalmology Authors: Petrou, P. A., Cunningham, D., Shimel, K., Harrington, M., Hammel, K., Cukras, C. A., Ferris, F. L., Chew, E. Y., Wong, W. T. Tags: Clinical Trials Source Type: research
Altered Amplitude of Low-Frequency Fluctuation in Primary Open-Angle Glaucoma: A Resting-State fMRI Study [Glaucoma]
Conclusions.
Primary open-angle glaucoma is a neurodegenerative disease involving multiple brain regions, including the visual cortices, DMN, limbic system, and motor and sensory networks. Moreover, the alterations in some of these networks are correlated with the progression of POAG; for the abnormal spontaneous neural activities in the left cuneus, bilateral MTG and right prefrontal cortex are correlated with glaucoma severity. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - January 13, 2015 Category: Opthalmology Authors: Li, T., Liu, Z., Li, J., Liu, Z., Tang, Z., Xie, X., Yang, D., Wang, N., Tian, J., Xian, J. Tags: Glaucoma Source Type: research
