Sex Differences in Retinal Microvasculature Through Puberty In Type 1 Diabetes: Are Girls at Greater Risk of Diabetic Microvascular Complications? [Retina]
Conclusions.
This is the first longitudinal study to repeatedly examine RVG through puberty in youth with T1D. Sex dimorphism was observed. Female sex was associated with lower LDRa, wider venules, and earlier onset of retinopathy. These RVG patterns have been associated with incident microvascular complications but did not reach statistical significance in this study. Larger studies are needed to investigate the RVG, microvascular complications, and sex associations early in the course of T1D. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - January 23, 2015 Category: Opthalmology Authors: Benitez-Aguirre, P., Craig, M. E., Cass, H. G., Sugden, C. J., Jenkins, A. J., Wang, J. J., Cusumano, J., Hodgson, L. A. B., Lee, K., Wong, T. Y., Donaghue, K. C. Tags: Retina Source Type: research
Quantitative Analysis of Iris Changes Following Mydriasis in Subjects With Different Mechanisms of Angle Closure [Glaucoma]
Conclusions.
There are significant differences in IA and IA loss per mm of pupil change following physiologic or pharmacologic mydriasis in Chinese subjects with dissimilar dominant mechanisms for AC. Dynamic iris change may have a more important role in angle closure where PB is the dominant mechanism. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - January 23, 2015 Category: Opthalmology Authors: Zhang, Y., Li, S. Z., Li, L., He, M. G., Thomas, R., Wang, N. L. Tags: Glaucoma Source Type: research
Infantile Nystagmus Syndrome Is Associated With Inefficiency of Goal-Directed Hand Movements [Low Vision]
Conclusions.
Collectively, the findings suggest that, in addition to the visuospatial homing-in problems associated with the syndrome, INS is associated with inefficiency of goal-directed hand movements. (http://www.trialregister.nl number, NTR2380.) (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - January 23, 2015 Category: Opthalmology Authors: Liebrand-Schurink, J., Cox, R. F. A., van Rens, G. H. M. B., Cillessen, A. H. N., Meulenbroek, R. G. J., Boonstra, F. N. Tags: Low Vision Source Type: research
Exome Array Analysis Identifies CAV1/CAV2 as a Susceptibility Locus for Intraocular Pressure [Glaucoma]
Conclusions.
Our results suggest that novel genetic variants and genes with multiple, less common variants may play a role in the control of IOP. The implication of the caveolin genes, CAV1/CAV2, as a common genetic factor influencing both IOP variations and POAG may provide new insights of the underlying mechanism leading to glaucoma and glaucomatous visual field loss. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - January 21, 2015 Category: Opthalmology Authors: Chen, F., Klein, A. P., Klein, B. E. K., Lee, K. E., Truitt, B., Klein, R., Iyengar, S. K., Duggal, P. Tags: Glaucoma Source Type: research
Role of Glutathione Peroxidase 4 in Conjunctival Epithelial Cells [Cornea]
Conclusion.
These results suggest that GPx4 is essential for maintaining oxidative homeostasis and keeping defense against oxidative stress in conjunctival epithelial cells. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - January 21, 2015 Category: Opthalmology Authors: Sakai, O., Uchida, T., Imai, H., Ueta, T., Amano, S. Tags: Cornea Source Type: research
Pseudo-Fovea Formation After Gene Therapy for RPE65-LCA [Retina]
Conclusions.
The slow emergence of pseudo-foveas many months after the initial increases in light sensitivity points to a substantial plasticity of the adult visual system and a complex interaction between it and the progression of underlying retinal disease. The visual significance of pseudo-foveas suggests careful consideration of treatment zones for future gene therapy trials. (ClinicalTrials.gov number, NCT00481546.) (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - January 21, 2015 Category: Opthalmology Authors: Cideciyan, A. V., Aguirre, G. K., Jacobson, S. G., Butt, O. H., Schwartz, S. B., Swider, M., Roman, A. J., Sadigh, S., Hauswirth, W. W. Tags: Retina Source Type: research
Fingerprinting of Galectins in Normal, P. aeruginosa-Infected, and Chemically Burned Mouse Corneas [Cornea]
Conclusions.
Our data demonstrate differential regulation of various members of the galectin family in the course of corneal infection and neovascularization. The emerging functionality of the sugar code of cell surface receptors via endogenous galectins reflect to the pertinent roles of the five tested galectins in the diseases of cornea. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - January 21, 2015 Category: Opthalmology Authors: Chen, W.-S., Cao, Z., Truong, L., Sugaya, S., Panjwani, N. Tags: Cornea Source Type: research
Activation of TLR3 Promotes the Degeneration of Retinal Ganglion Cells by Upregulating the Protein Levels of JNK3 [Retina]
Conclusions.
Results presented in this study show that the activation of TLR3 alone promotes the degeneration of RGCs by upregulating the protein levels of JNK3. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - January 19, 2015 Category: Opthalmology Authors: Chintala, S. K., Putris, N., Geno, M. Tags: Retina Source Type: research
Novel Quantitative Assessment of Metamorphopsia in Maculopathy [Low Vision]
Conclusions.
Three alternative quantifications of monocular spatial distortion in the central visual field generated uncorrelated estimates of visual distortion. It is therefore unlikely that metamorphopsia is caused solely by retinal displacement, but instead involves additional top-down information, knowledge about the scene, and perhaps, cortical reorganization. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - January 19, 2015 Category: Opthalmology Authors: Wiecek, E., Lashkari, K., Dakin, S. C., Bex, P. Tags: Low Vision Source Type: research
A Nationwide Population-Based Study of Low Vision and Blindness in South Korea [Low Vision]
Conclusions.
This population-based study provides useful information for planning optimal public eye health care services in South Korea. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - January 19, 2015 Category: Opthalmology Authors: Park, S. H., Lee, J. S., Heo, H., Suh, Y.-W., Kim, S.-H., Lim, K. H., Moon, N. J., Lee, S. J., Park, S. H., Baek, S.-H., for the Epidemiologic Survey Committee in the Korean Ophthalmological Society Tags: Low Vision Source Type: research
Association of Common SIX6 Polymorphisms With Peripapillary Retinal Nerve Fiber Layer Thickness: The Singapore Chinese Eye Study [Glaucoma]
Conclusions.
Nonglaucomatous individuals with the SIX6 missense variant have reduced RNFL thickness in regions known to be particularly affected in those with glaucoma. This may be the primary mechanism for increased risk of POAG in individuals who carry the SIX6 His141 risk variant. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - January 19, 2015 Category: Opthalmology Authors: Cheng, C.-Y., Allingham, R. R., Aung, T., Tham, Y.-C., Hauser, M. A., Vithana, E. N., Khor, C. C., Wong, T. Y. Tags: Glaucoma Source Type: research
Ultrastructure of Adenovirus Keratitis [Immunology and Microbiology]
Conclusions.
By transmission electron microscopy, injected HAdV-D37 readily enters stromal cells in the C57Bl/6j mouse cornea and induces stromal inflammation, as was shown previously by light microscopy. However, electron microscopy also revealed dense, static arrays of intracytoplasmic virus, suggesting a block in viral capsid disassembly and viral DNA nuclear entry. These findings may explain why human adenoviruses do not replicate in the mouse corneal stroma. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - January 19, 2015 Category: Opthalmology Authors: Mukherjee, S., Zhou, X., Rajaiya, J., Chodosh, J. Tags: Immunology and Microbiology Source Type: research
Mechanisms for Discomfort Glare in Central Vision [Visual Psychophysics and Physiological Optics]
Conclusions.
Discomfort glare in central vision is more closely associated with the spatial properties of the glare source, such as contrast-defined edges, than the overall amount of light entering the eye. The results suggest that discomfort glare in lighting installations could be reduced while maintaining adequate illuminance levels by an appropriate choice of illuminant source size. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - January 19, 2015 Category: Opthalmology Authors: Bargary, G., Jia, Y., Barbur, J. L. Tags: Visual Psychophysics and Physiological Optics Source Type: research
Posterior Pole Retinal Abnormalities in Mild Asymptomatic FEVR [Retina]
Conclusions.
Asymptomatic individuals with stage I or II FEVR had several abnormalities in the posterior pole noted with more retinal vessels, a significantly larger disc-to-macula distance as well as a remarkably smaller optic disc with a decreased horizontal diameter. These findings will facilitate the early diagnosis of FEVR and are important for adequate genetic counseling as well as the prevention and treatment of this disease. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - January 19, 2015 Category: Opthalmology Authors: Yuan, M., Yang, Y., Yu, S., Hu, A., Lu, L., Ma, J., Ding, X., Li, J. Tags: Retina Source Type: research
Comparison of Rates of Change Between Binocular and Monocular Visual Fields [Glaucoma]
Conclusions.
The rate of change in BVFs was intermediate between the rates of the faster-changing and slower-changing eyes. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - January 19, 2015 Category: Opthalmology Authors: Chun, Y. S., Shin, J.-H., Park, I. K. Tags: Glaucoma Source Type: research
