Pseudo-Fovea Formation After Gene Therapy for RPE65-LCA [Retina]

Conclusions.
The slow emergence of pseudo-foveas many months after the initial increases in light sensitivity points to a substantial plasticity of the adult visual system and a complex interaction between it and the progression of underlying retinal disease. The visual significance of pseudo-foveas suggests careful consideration of treatment zones for future gene therapy trials. (ClinicalTrials.gov number, NCT00481546.)

Source: Investigative Ophthalmology - January 21, 2015 Category: Opthalmology Authors: Cideciyan, A. V., Aguirre, G. K., Jacobson, S. G., Butt, O. H., Schwartz, S. B., Swider, M., Roman, A. J., Sadigh, S., Hauswirth, W. W. Tags: Retina Source Type: research