Ultrastructure of Adenovirus Keratitis [Immunology and Microbiology]

Conclusions. By transmission electron microscopy, injected HAdV-D37 readily enters stromal cells in the C57Bl/6j mouse cornea and induces stromal inflammation, as was shown previously by light microscopy. However, electron microscopy also revealed dense, static arrays of intracytoplasmic virus, suggesting a block in viral capsid disassembly and viral DNA nuclear entry. These findings may explain why human adenoviruses do not replicate in the mouse corneal stroma.
Source: Investigative Ophthalmology - Category: Opthalmology Authors: Tags: Immunology and Microbiology Source Type: research