Association of Common SIX6 Polymorphisms With Peripapillary Retinal Nerve Fiber Layer Thickness: The Singapore Chinese Eye Study [Glaucoma]

Conclusions.
Nonglaucomatous individuals with the SIX6 missense variant have reduced RNFL thickness in regions known to be particularly affected in those with glaucoma. This may be the primary mechanism for increased risk of POAG in individuals who carry the SIX6 His141 risk variant.

Source: Investigative Ophthalmology - January 19, 2015 Category: Opthalmology Authors: Cheng, C.-Y., Allingham, R. R., Aung, T., Tham, Y.-C., Hauser, M. A., Vithana, E. N., Khor, C. C., Wong, T. Y. Tags: Glaucoma Source Type: research