Importance of Eye Position on Spatial Localization in Blind Subjects Wearing an Argus II Retinal Prosthesis [Low Vision]
Conclusions.
Eye position affected perceptual localization of images generated by the Argus II prosthesis, and consequently visuomotor coordination, even 4 years following implantation. Affected individuals developed strategies for visually guided movements to attenuate the impact of eye and head misalignment. Our observations provide indications for rehabilitation procedures and for the design of upcoming retinal prostheses. (ClinicalTrials.gov number, NCT00407602.) (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - December 18, 2014 Category: Opthalmology Authors: Sabbah, N., Authie, C. N., Sanda, N., Mohand-Said, S., Sahel, J.-A., Safran, A. B. Tags: Low Vision Source Type: research
DNA Copy Number Variants of Known Glaucoma Genes in Relation to Primary Open-Angle Glaucoma [Genetics]
Conclusions.
The CNV analysis of a large set of cases and controls revealed the presence of rare CNVs in known POAG susceptibility genes. Our data suggest that these rare CNVs may contribute to POAG pathogenesis and merit functional evaluation. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - December 18, 2014 Category: Opthalmology Authors: Liu, Y., Garrett, M. E., Yaspan, B. L., Bailey, J. C., Loomis, S. J., Brilliant, M., Budenz, D. L., Christen, W. G., Fingert, J. H., Gaasterland, D., Gaasterland, T., Kang, J. H., Lee, R. K., Lichter, P., Moroi, S. E., Realini, A., Richards, J. E., Schuma Tags: Genetics Source Type: research
Preparative and Biosynthetic Insights Into pdA2E and isopdA2E, Retinal-Derived Fluorophores of Retinal Pigment Epithelial Lipofuscin [Biochemistry and Molecular Biology]
Conclusions.
Our results facilitate the understanding of compositions and biosynthetic pathways of adverse RPE lipofuscin. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - December 18, 2014 Category: Opthalmology Authors: Zhao, J., Yao, K., Jin, Q., Jiang, K., Chen, J., Liu, Z., Li, J., Wu, Y. Tags: Biochemistry and Molecular Biology Source Type: research
Modulation of VEGF-Induced Retinal Vascular Permeability by Peroxisome Proliferator-Activated Receptor-{beta}/{delta} [Retinal Cell Biology]
Conclusions.
These data suggest a protective effect for PPARβ/ antagonism against VEGF-induced vascular permeability, possibly through reduced VEGFR expression. Therefore, antagonism/reverse agonism of PPARβ/ siRNA may represent a novel therapeutic methodology against retinal hyperpermeability and is worthy of future investigation. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - December 18, 2014 Category: Opthalmology Authors: Suarez, S., McCollum, G. W., Bretz, C. A., Yang, R., Capozzi, M. E., Penn, J. S. Tags: Retinal Cell Biology Source Type: research
Effects of Lowering Cerebrospinal Fluid Pressure on the Shape of the Peripapillary Retina in Intracranial Hypertension [Eye Movement, Strabismus, Amblyopia, and Neuro-Ophthalmology]
Conclusions.
The subsurface contour of the ppRPE/BM layer is a dynamic property that changes with CSF pressure-lowering interventions. It can supplement the RNFL thickness as an indirect gauge of ICP and is particularly helpful in patients with secondary optic atrophy. Direct measurements of displacement at the basement membrane opening may serve as a more convenient office-based surrogate for shape analysis. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - December 18, 2014 Category: Opthalmology Authors: Sibony, P., Kupersmith, M. J., Honkanen, R., Rohlf, F. J., Torab-Parhiz, A. Tags: Eye Movement, Strabismus, Amblyopia, and Neuro-Ophthalmology Source Type: research
Erythropoietin Exerts a Neuroprotective Function Against Glutamate Neurotoxicity in Experimental Diabetic Retina [Retina]
Conclusions.
Erythropoietin showed a neuroprotective function against Glu-mediated neurotoxicity both in diabetic rat retina and in Glu-treated R28 cells. The neuroprotective mechanisms were largely through maintaining the normal expression of glutamate–glutamine cycle-related proteins and inhibiting AIF translocation and PAR polymer formation. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - December 15, 2014 Category: Opthalmology Authors: Gu, L., Xu, H., Wang, F., Xu, G., Sinha, D., Wang, J., Xu, J.-Y., Tian, H., Gao, F., Li, W., Lu, L., Zhang, J., Xu, G.-T. Tags: Retina Source Type: research
G Protein Signaling in the Retina and Beyond: The Cogan Lecture [Lectures]
(Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - December 15, 2014 Category: Opthalmology Authors: Martemyanov, K. A. Tags: Lectures Source Type: research
Introducing Kirill A. Martemyanov, the 2014 Recipient of the Cogan Award [Lectures]
(Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - December 15, 2014 Category: Opthalmology Authors: Arshavsky, V. Y. Tags: Lectures Source Type: research
Preservation of the Structure of Enzymatically-Degraded Bovine Vitreous Using Synthetic Proteoglycan Mimics [Biochemistry and Molecular Biology]
Conclusions.
Proteoglycan mimics preserved bovine vitreous physical properties after enzymatic degradation. These compounds may be useful in delaying or preventing the pathological effects of age-related, or enzymatically-induced, degradation of the vitreous body. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - December 15, 2014 Category: Opthalmology Authors: Zhang, Q., Filas, B. A., Roth, R., Heuser, J., Ma, N., Sharma, S., Panitch, A., Beebe, D. C., Shui, Y.-B. Tags: Biochemistry and Molecular Biology Source Type: research
Monitoring of Strain-Dependent Responsiveness to TLR Activation in the Mouse Anterior Segment Using SD-OCT [Cornea]
Conclusions.
Spectral-domain OCT enables high-resolution, longitudinal, in vivo imaging of anterior segment inflammation in mice and revealed novel strain– and time-dependent differences in response to distinct TLR activation in the cornea. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - December 12, 2014 Category: Opthalmology Authors: Downie, L. E., Stainer, M. J., Chinnery, H. R. Tags: Cornea Source Type: research
Baseline OCT Measurements in the Idiopathic Intracranial Hypertension Treatment Trial, Part I: Quality Control, Comparisons, and Variability [Eye Movements, Strabismus, Amblyopia, and Neuro-Ophthalmology]
Conclusions.
Spectral-domain OCT provides reliable continuous variables and quantified assessment of structural alterations due to papilledema. (ClinicalTrials.gov number, NCT01003639.) (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - December 12, 2014 Category: Opthalmology Authors: OCT Sub-Study Committee for the NORDIC Idiopathic Intracranial Hypertension Study Group Tags: Eye Movements, Strabismus, Amblyopia, and Neuro-Ophthalmology Source Type: research
Baseline OCT Measurements in the Idiopathic Intracranial Hypertension Treatment Trial, Part II: Correlations and Relationship to Clinical Features [Eye Movements, Strabismus, Amblyopia, and Neuro-Ophthalmology]
Conclusions.
In newly diagnosed IIH, OCT demonstrated alterations of the peripapillary retina and ONH correlate with Frisén grading of papilledema. At presentation, OCT measures of papilledema, in patients with newly diagnosed IIH and mild vision loss, do not correlate with clinical features or visual dysfunction. (ClinicalTrials.gov number, NCT01003639.) (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - December 12, 2014 Category: Opthalmology Authors: OCT Sub-Study Committee for the NORDIC Idiopathic Intracranial Hypertension Study Group Tags: Eye Movements, Strabismus, Amblyopia, and Neuro-Ophthalmology Source Type: research
Age- and Race-Related Differences in Human Scleral Material Properties [Glaucoma]
Conclusions.
The age- and race-related differences in scleral material properties result in a loss of scleral compliance due to a higher shear stiffness and a lower level of stretch at which the collagen fibrils uncrimp. The loss of compliance should lead to larger high frequency IOP fluctuations and changes in the optic nerve head (ONH) biomechanical response in the elderly and in persons of African ancestry, and may contribute to the higher susceptibility to glaucoma in these at-risk populations. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - December 12, 2014 Category: Opthalmology Authors: Grytz, R., Fazio, M. A., Libertiaux, V., Bruno, L., Gardiner, S., Girkin, C. A., Downs, J. C. Tags: Glaucoma Source Type: research
An Objective Evaluation of Gaze Tracking in Humphrey Perimetry and the Relation With the Reproducibility of Visual Fields: A Pilot Study in Glaucoma [Glaucoma]
Conclusions.
Gaze tracking parameters are closely related to the reproducibility of VF results, and it would be beneficial to objectively use these parameters when estimating the reliability of VF tests. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - December 12, 2014 Category: Opthalmology Authors: Ishiyama, Y., Murata, H., Mayama, C., Asaoka, R. Tags: Glaucoma Source Type: research
Relationship Between Iris Surface Features and Angle Width in Asian Eyes [Glaucoma]
Conclusions.
Iris surface features, assessed and measured from slit-lamp photographs, correlated well with anterior chamber angle width; irises with more crypts and lighter color were associated with wider angle. These findings may provide another imaging modality to assess angle closure risk based on iris surface features. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - December 12, 2014 Category: Opthalmology Authors: Sidhartha, E., Nongpiur, M. E., Cheung, C. Y., He, M., Wong, T. Y., Aung, T., Cheng, C.-Y. Tags: Glaucoma Source Type: research
