Modulation of VEGF-Induced Retinal Vascular Permeability by Peroxisome Proliferator-Activated Receptor-{beta}/{delta} [Retinal Cell Biology]

Conclusions.
These data suggest a protective effect for PPARβ/ antagonism against VEGF-induced vascular permeability, possibly through reduced VEGFR expression. Therefore, antagonism/reverse agonism of PPARβ/ siRNA may represent a novel therapeutic methodology against retinal hyperpermeability and is worthy of future investigation.

Source: Investigative Ophthalmology - December 18, 2014 Category: Opthalmology Authors: Suarez, S., McCollum, G. W., Bretz, C. A., Yang, R., Capozzi, M. E., Penn, J. S. Tags: Retinal Cell Biology Source Type: research