Erythropoietin Exerts a Neuroprotective Function Against Glutamate Neurotoxicity in Experimental Diabetic Retina [Retina]

Conclusions.
Erythropoietin showed a neuroprotective function against Glu-mediated neurotoxicity both in diabetic rat retina and in Glu-treated R28 cells. The neuroprotective mechanisms were largely through maintaining the normal expression of glutamate–glutamine cycle-related proteins and inhibiting AIF translocation and PAR polymer formation.

Source: Investigative Ophthalmology - December 15, 2014 Category: Opthalmology Authors: Gu, L., Xu, H., Wang, F., Xu, G., Sinha, D., Wang, J., Xu, J.-Y., Tian, H., Gao, F., Li, W., Lu, L., Zhang, J., Xu, G.-T. Tags: Retina Source Type: research