Differential Proteomic Analyses of Cataracts From Rat Models of Type 1 and 2 Diabetes [Lens]

Conclusions.
The results suggest that osmotic damage, GSH loss, and decreased ATP production might be important pathological mechanisms in T1DC formation, whereas crystallin modification and cross-linking/aggregation as well as IF degradation may play more crucial roles in T2DC formation.

Source: Investigative Ophthalmology - December 9, 2014 Category: Opthalmology Authors: Su, S., Leng, F., Guan, L., Zhang, L., Ge, J., Wang, C., Chen, S., Liu, P. Tags: Lens Source Type: research