O-GlcNAc Modification of Transcription Factor Sp1 Mediates Hyperglycemia-Induced VEGF-A Upregulation in Retinal Cells [Biochemistry and Molecular Biology]

Conclusions. Hyperglycemia-driven VEGF-A production is mediated by elevated O-GlcNAc modification of the Sp1 transcription factor. This mechanism may be significant in the pathogenesis of preclinical DR through VEGF-A upregulation.

http://www.iovs.org/cgi/content/full/55/12/7862?rss=1

Source: Investigative Ophthalmology - December 9, 2014 Category: Opthalmology Authors: Donovan, K., Alekseev, O., Qi, X., Cho, W., Azizkhan-Clifford, J. Tags: Biochemistry and Molecular Biology Source Type: research