Protective Effects of {beta}1/2 Adrenergic Receptor Deletion in a Model of Oxygen-Induced Retinopathy [Biochemistry and Molecular Biology]
Conclusions.
We confirm that β1- and β2-ARs play a pivotal role in retinal angiogenesis. In their presence, β3-ARs potentiate angiogenic responses, whereas, in their absence, β3-ARs sustain the angiogenic drive. These results suggest β-ARs as promising targets for therapies aimed to counteract proliferative retinopathies.
Source: Investigative Ophthalmology - Category: Opthalmology Authors: Dal Monte, M., Cammalleri, M., Mattei, E., Filippi, L., Bagnoli, P. Tags: Biochemistry and Molecular Biology Source Type: research