A New Small Molecule For Treating Inflammation and Chorioretinal Neovascularization in Relapsing-Remitting and Chronic Experimental Autoimmune Uveitis [Immunology and Microbiology]
Conclusions.
We investigated a new dihydroorotate dehydrogenase inhibitor as treatment for primary and recurrent disease in relapsing-remitting and chronic rat models of experimental autoimmune uveitis. The small molecule compound PP-001 suppressed proliferation and cytokine secretion of autoreactive T cells (i.e., IFN-g, IL-17, and VEGF) and chorioretinal neovascularization in chronic EAU.
Source: Investigative Ophthalmology - Category: Opthalmology Authors: Diedrichs-Mohring, M., Leban, J., Strobl, S., Obermayr, F., Wildner, G. Tags: Immunology and Microbiology Source Type: research