Activation of Liver X Receptor Protects Inner Retinal Damage Induced by N-methyl-D-aspartate [Retina]

Conclusions.
Activation of LXRβ with a synthetic LXR ligand TO90 protects the inner retinal damage induced by NMDA in mice. We speculate the protective effect is associated with inhibition of the NF-B signaling pathway and reduction of Aβ formation in retina. The LXR agonists may become a new class of neuroprotective agent for retinal diseases associated with glutamate-induced excitotoxicity.

Source: Investigative Ophthalmology - February 13, 2015 Category: Opthalmology Authors: Zheng, S., Yang, H., Chen, Z., Zheng, C., Lei, C., Lei, B. Tags: Retina Source Type: research