Neurosteroids Are Endogenous Neuroprotectants in an Ex Vivo Glaucoma Model [Glaucoma]
Conclusions.
These results indicate that the synthesis of allopregnanolone is enhanced mainly via NMDARs in the pressure-loaded retina, and that allopregnanolone diminishes pressure-mediated retinal degeneration via GABAA receptors. Allopregnanolone and other related neurosteroids may serve as potential novel therapeutic targets for the prevention of pressure-induced retinal damage in glaucoma.
Source: Investigative Ophthalmology - Category: Opthalmology Authors: Ishikawa, M., Yoshitomi, T., Zorumski, C. F., Izumi, Y. Tags: Glaucoma Source Type: research
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