Neurosteroids Are Endogenous Neuroprotectants in an Ex Vivo Glaucoma Model [Glaucoma]

Conclusions. These results indicate that the synthesis of allopregnanolone is enhanced mainly via NMDARs in the pressure-loaded retina, and that allopregnanolone diminishes pressure-mediated retinal degeneration via GABAA receptors. Allopregnanolone and other related neurosteroids may serve as potential novel therapeutic targets for the prevention of pressure-induced retinal damage in glaucoma.
Source: Investigative Ophthalmology - Category: Opthalmology Authors: Tags: Glaucoma Source Type: research