Oxidative Stress and Light-Evoked Responses of the Posterior Segment in a Mouse Model of Diabetic Retinopathy [Retinal Cell Biology]

Conclusions.
Apparent diffusion coefficient MRI is a sensitive method for evaluating choroid thickness and its light-evoked expansion together with phototransduction-dependent changes in the SRS layer in mice in vivo. Because ADC MRI exploits an endogenous contrast mechanism, its translational potential is promising; it can also be performed in concert with manganese-enhanced MRI (MEMRI). Our data support a link between diabetes-related oxidative stress and rod, but not choroidal, pathophysiology.

Source: Investigative Ophthalmology - January 27, 2015 Category: Opthalmology Authors: Berkowitz, B. A., Grady, E. M., Khetarpal, N., Patel, A., Roberts, R. Tags: Retinal Cell Biology Source Type: research