The Use of Time-Lapse Optical Coherence Tomography to Image the Effects of Microapplied Toxins on the Retina [Physiology and Pharmacology]

Conclusions.
Retinotoxin-induced changes in retinal layer reflectivity and thickness under the microperfusion tube in OCT images closely matched the histological evidence of retinal injury. Time-lapse OCT imaging of the microperfused local retina has the potential to accelerate drug retinotoxicological screening and expand the use of OCT as an evaluation tool for preclinical animal testing.

Source: Investigative Ophthalmology - January 23, 2015 Category: Opthalmology Authors: Majdi, J. A., Qian, H., Li, Y., Langsner, R. J., Shea, K. I., Agrawal, A., Hammer, D. X., Hanig, J. P., Cohen, E. D. Tags: Physiology and Pharmacology Source Type: research