Sildenafil-Induced Reversible Impairment of Rod and Cone Phototransduction in Monkeys [Retina]

Conclusions.
Sildenafil produced reversible impairment of the rod and cone phototransduction in monkeys. Meanwhile, involvement of the postreceptoral retinal components was suggested. These findings contribute to the clarification of sildenafil-induced visual disturbances. It is suggested that the photoreceptors are predominantly, but not exclusively, affected in the retina of humans with sildenafil-induced visual disturbances.

Source: Investigative Ophthalmology - January 29, 2015 Category: Opthalmology Authors: Kinoshita, J., Iwata, N., Shimoda, H., Kimotsuki, T., Yasuda, M. Tags: Retina Source Type: research