Subcellular Distribution and Activity of Mechanistic Target of Rapamycin in Aged Retinal Pigment Epithelium [Retinal Cell Biology]

Conclusions. Aging changes the subcellular localization and function of mTOR in the RPE. Increased mTORC1 inhibits POS degradation and may further exacerbate lysosome dysfunction of aged RPE.

http://www.iovs.org/cgi/content/full/55/12/8638?rss=1

Source: Investigative Ophthalmology - December 30, 2014 Category: Opthalmology Authors: Yu, B., Xu, P., Zhao, Z., Cai, J., Sternberg, P., Chen, Y. Tags: Retinal Cell Biology Source Type: research