Identification of Multiple DNA Copy Number Alterations Including Frequent 8p11.22 Amplification in Conjunctival Squamous Cell Carcinoma [Anatomy and Pathology/Oncology]

Conclusions. Conjunctival SCC contains a range of chromosomal alterations potentially important in tumor formation and growth. Amplification of 8p11.22 and overexpression of ADAM3A suggests a potential role for this protease. Our findings also suggest that defects in DNA repair loci are important in sporadic cSCC.

http://www.iovs.org/cgi/content/full/55/12/8604?rss=1

Source: Investigative Ophthalmology - December 30, 2014 Category: Opthalmology Authors: Asnaghi, L., Alkatan, H., Mahale, A., Othman, M., Alwadani, S., Al-Hussain, H., Jastaneiah, S., Yu, W., Maktabi, A., Edward, D. P., Eberhart, C. G. Tags: Anatomy and Pathology/Oncology Source Type: research