The Role of the Hypoxia Response in Shaping Retinal Vascular * Development in the Absence of Norrin/Frizzled4 Signaling [Retinal Cell Biology]

Conclusions.
In the absence of Norrin or Frizzled4, the vascular phenotype is determined by the primary defect in Norrin/Frizzled4 signaling (i.e., canonical Wnt signaling) and compensatory responses resulting from hypoxia. This work may be useful in guiding therapeutic strategies for the treatment of familial exudative vitreoretinopathy (FEVR).

Source: Investigative Ophthalmology - December 30, 2014 Category: Opthalmology Authors: Rattner, A., Wang, Y., Zhou, Y., Williams, J., Nathans, J. Tags: Retinal Cell Biology Source Type: research