Quantitative Imaging of Enzymatic Vitreolysis-Induced Fiber Remodeling [Physiology and Pharmacology]

Conclusions.
Proteoglycan loss due to enzymatic vitreolysis differentially increases fiber alignment at locations where tractions are most common. We hypothesize that a similar mechanism leads to retinal complications during age-related vitreous degeneration. Structural changes to the entire vitreous body (as opposed to the vitreoretinal interface alone) should be evaluated during preclinical testing of pharmacological vitreolysis candidates.

Source: Investigative Ophthalmology - December 30, 2014 Category: Opthalmology Authors: Filas, B. A., Shah, N. S., Zhang, Q., Shui, Y.-B., Lake, S. P., Beebe, D. C. Tags: Physiology and Pharmacology Source Type: research