Proinflammatory Responses Induced by CD40 in Retinal Endothelial and Muller Cells are Inhibited by Blocking CD40-Traf2,3 or CD40-Traf6 Signaling [Retinal Cell Biology]

Conclusions. Blockade of a single CD40-TRAF pathway was sufficient to impair ICAM-1, MCP-1, PGE2, and VEGF upregulation in retinal endothelial and/or Müller cells. Blockade of CD40-TRAF signaling may control retinopathies.

http://www.iovs.org/cgi/content/full/55/12/8590?rss=1

Source: Investigative Ophthalmology - December 30, 2014 Category: Opthalmology Authors: Portillo, J.-A. C., Schwartz, I., Zarini, S., Bapputty, R., Kern, T. S., Gubitosi-Klug, R. A., Murphy, R. C., Subauste, M. C., Subauste, C. S. Tags: Retinal Cell Biology Source Type: research