A guide to immunometabolism for immunologists
Nature Reviews Immunology 16, 553 (2016).
doi:10.1038/nri.2016.70
Authors: Luke A. J. O'Neill, Rigel J. Kishton & Jeff Rathmell
In recent years a substantial number of findings have been made in the area of immunometabolism, by which we mean the changes in intracellular metabolic pathways in immune cells that alter their function. Here, we provide a brief refresher course on six of the major (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - July 10, 2016 Category: Allergy & Immunology Authors: Luke A. J. O'Neill Rigel J. Kishton Jeff Rathmell Tags: Review Source Type: research
Immunity by equilibrium
Nature Reviews Immunology 16, 524 (2016).
doi:10.1038/nri.2016.75
Author: Gérard Eberl
The classical model of immunity posits that the immune system reacts to pathogens and injury and restores homeostasis. Indeed, a century of research has uncovered the means and mechanisms by which the immune system recognizes danger and regulates its own activity. However, this classical model (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - July 10, 2016 Category: Allergy & Immunology Authors: G érard Eberl Tags: Perspectives Source Type: research
B cell-T cell interaction: antigen bridge to antigen presentation
Nature Reviews Immunology 16, 467 (2016).
doi:10.1038/nri.2016.82
Author: Gail A. Bishop
Gail Bishop describes a 1985 study by Antonio Lanzavecchia that changed our understanding of B cell–T cell interactions. (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - July 10, 2016 Category: Allergy & Immunology Authors: Gail A. Bishop Tags: Research Highlight Source Type: research
Immune responses and immunopathology in acute and chronic viral hepatitis
Nature Reviews Immunology 16, 509 (2016).
doi:10.1038/nri.2016.69
Authors: Eui-Cheol Shin, Pil Soo Sung & Su-Hyung Park
Hepatitis A virus (HAV), hepatitis B virus (HBV) and hepatitis C virus (HCV) are responsible for most cases of viral hepatitis. Infection by each type of virus results in a different typical natural disease course and clinical outcome that are determined by virological and immunological (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - July 3, 2016 Category: Allergy & Immunology Authors: Eui-Cheol Shin Pil Soo Sung Su-Hyung Park Tags: Review Source Type: research
Combinatorial antibody libraries: new advances, new immunological insights
Nature Reviews Immunology 16, 498 (2016).
doi:10.1038/nri.2016.67
Author: Richard A. Lerner
Immunochemists have become quite proficient in engineering existing antibody molecules to control their pharmacological properties. However, in terms of generating new antibodies, the combinatorial antibody library has become a central feature of modern immunochemistry. These libraries are essentially an immune system in a test tube (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - July 3, 2016 Category: Allergy & Immunology Authors: Richard A. Lerner Tags: Review Source Type: research
Macrophages: Memories of the dead give strength
Nature Reviews Immunology 16, 464 (2016).
doi:10.1038/nri.2016.81
Author: Olive Leavy
The uptake of apoptotic corpses generates a molecular memory in macrophages that boosts the innate immune response. (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - July 3, 2016 Category: Allergy & Immunology Authors: Olive Leavy Tags: Research Highlight Source Type: research
T cells: Mitochondrial shape shifters
Nature Reviews Immunology 16, 402 (2016).
doi:10.1038/nri.2016.79
Author: Lucy Bird
Mitochondrial remodelling instructs metabolic adaptations in T cells. (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - June 27, 2016 Category: Allergy & Immunology Authors: Lucy Bird Tags: Research Highlight Source Type: research
Innate sensing of oxidation-specific epitopes in health and disease
Nature Reviews Immunology 16, 485 (2016).
doi:10.1038/nri.2016.63
Authors: Christoph J. Binder, Nikolina Papac-Milicevic & Joseph L. Witztum
Ageing, infections and inflammation result in oxidative stress that can irreversibly damage cellular structures. The oxidative damage of lipids in membranes or lipoproteins is one of these deleterious consequences that not only alters lipid function but also leads to the formation of neo-self epitopes — (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - June 26, 2016 Category: Allergy & Immunology Authors: Christoph J. Binder Nikolina Papac-Milicevic Joseph L. Witztum Tags: Review Source Type: research
The unfolded protein response in immunity and inflammation
Nature Reviews Immunology 16, 469 (2016).
doi:10.1038/nri.2016.62
Authors: Joep Grootjans, Arthur Kaser, Randal J. Kaufman & Richard S. Blumberg
The unfolded protein response (UPR) is a highly conserved pathway that allows the cell to manage endoplasmic reticulum (ER) stress that is imposed by the secretory demands associated with environmental forces. In this role, the UPR has increasingly been shown to have crucial functions in (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - June 26, 2016 Category: Allergy & Immunology Authors: Joep Grootjans Arthur Kaser Randal J. Kaufman Richard S. Blumberg Tags: Review Source Type: research
Computational flow cytometry: helping to make sense of high-dimensional immunology data
Nature Reviews Immunology 16, 449 (2016).
doi:10.1038/nri.2016.56
Authors: Yvan Saeys, Sofie Van Gassen & Bart N. Lambrecht
Recent advances in flow cytometry allow scientists to measure an increasing number of parameters per cell, generating huge and high-dimensional datasets. To analyse, visualize and interpret these data, newly available computational techniques should be adopted, evaluated and improved upon by the immunological community. Computational flow (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - June 19, 2016 Category: Allergy & Immunology Authors: Yvan SaeysSofie Van GassenBart N. Lambrecht Tags: Review Source Type: research
Immune memory: Inflammasomes drive NK cell memory
Nature Reviews Immunology 16, 405 (2016).
doi:10.1038/nri.2016.74
Author: Elisabeth Kugelberg
Contact hypersensitivity induces a memory NK cell response that requires the NLRP3 inflammasome in tissue-resident macrophages. (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - June 19, 2016 Category: Allergy & Immunology Authors: Elisabeth Kugelberg Tags: Research Highlight Source Type: research
Inflammasome: To die or not to die
Nature Reviews Immunology 16, 404 (2016).
doi:10.1038/nri.2016.73
Author: Kirsty Minton
Non-canonical inflammasome activation by self-derived oxidized phospholipid promotes both IL-1β release and cell survival. (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - June 19, 2016 Category: Allergy & Immunology Authors: Kirsty Minton Tags: Research Highlight Source Type: research
Cell death and immunity: Gasdermins: the hole picture emerges
Nature Reviews Immunology 16, 401 (2016).
doi:10.1038/nri.2016.76
Author: Yvonne Bordon
Gasdermins induce pyroptosis by forming pores in the cell membrane. (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - June 19, 2016 Category: Allergy & Immunology Authors: Yvonne Bordon Tags: Research Highlight Source Type: research
C-type lectin receptors in the control of T helper cell differentiation
Nature Reviews Immunology 16, 433 (2016).
doi:10.1038/nri.2016.55
Authors: Teunis B. H. Geijtenbeek & Sonja I. Gringhuis
Pathogen recognition by C-type lectin receptors (CLRs) expressed by dendritic cells is important not only for antigen presentation, but also for the induction of appropriate adaptive immune responses via T helper (TH) cell differentiation. CLRs act either by themselves or in cooperation with (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - June 12, 2016 Category: Allergy & Immunology Authors: Teunis B. H. GeijtenbeekSonja I. Gringhuis Tags: Review Source Type: research
Inflammasomes: mechanism of assembly, regulation and signalling
Nature Reviews Immunology 16, 407 (2016).
doi:10.1038/nri.2016.58
Authors: Petr Broz & Vishva M. Dixit
Inflammasomes are multiprotein signalling platforms that control the inflammatory response and coordinate antimicrobial host defences. They are assembled by pattern-recognition receptors following the detection of pathogenic microorganisms and danger signals in the cytosol of host cells, and they activate inflammatory caspases to produce cytokines and (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - June 12, 2016 Category: Allergy & Immunology Authors: Petr BrozVishva M. Dixit Tags: Review Source Type: research
