Infectious disease: γ δ T cells stop malarial comeback
Nature Reviews Immunology 18, 150 (2018).
doi:10.1038/nri.2018.15
Author: Yvonne Bordon
γδ T cells prevent the recurrence of malarial parasitaemia by producing M-CSF. (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - February 26, 2018 Category: Allergy & Immunology Authors: Yvonne Bordon Tags: Research Highlight Source Type: research
Foreign antigen-independent memory-phenotype CD4+ T cells: a new player in innate immunity?
Nature Reviews Immunology 18, 1 (2018).
doi:10.1038/nri.2018.13
Authors: Ross M. Kedl & Jason T. White
In their present Correspondence on our recent Opinion article (Antigen-inexperienced memory CD8+ T cells: where they come from and why we need them. Nat. Rev. Immunol.17, 391–400 (2017)), Kawabe et al. present a compelling case for the consideration (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - February 26, 2018 Category: Allergy & Immunology Authors: Ross M. Kedl Jason T. White Tags: Reply Source Type: research
Foreign antigen-independent memory-phenotype CD4+ T cells: a new player in innate immunity?
Nature Reviews Immunology 18, 1 (2018).
doi:10.1038/nri.2018.12
Authors: Takeshi Kawabe, Jinfang Zhu & Alan Sher
In an Opinion article published in May 2017 (Antigen-inexperienced memory CD8+ T cells: where they come from and why we need them. Nat. Rev. Immunol.17, 391–400 (2017)), Ross Kedl and colleagues provided a comprehensive review concerning foreign antigen-inexperienced CD8 (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - February 26, 2018 Category: Allergy & Immunology Authors: Takeshi Kawabe Jinfang Zhu Alan Sher Tags: Correspondence Source Type: research
Microbiota: Pathobiont peacekeepers
Nature Reviews Immunology 18, 152 (2018).
doi:10.1038/nri.2018.11
Author: Kirsty Minton
Pathobiont-specific peripherally derived regulatory T cells have an important role in maintaining gut homeostasis. (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - February 16, 2018 Category: Allergy & Immunology Authors: Kirsty Minton Tags: Research Highlight Source Type: research
Tumour immunology: NK cells bring in the troops
Nature Reviews Immunology 18, 151 (2018).
doi:10.1038/nri.2018.14
Author: Yvonne Bordon
NK cells recruit cDC1s to the tumour microenviroment by producing the chemokines CCL5 and XCL1. (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - February 16, 2018 Category: Allergy & Immunology Authors: Yvonne Bordon Tags: Research Highlight Source Type: research
Immunotherapy: Direct shot
Nature Reviews Immunology 18, 149 (2018).
doi:10.1038/nri.2018.10
Author: Lucy Bird
Intratumoural vaccination with immune-enhancing agents eradicates tumour metastases. (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - February 16, 2018 Category: Allergy & Immunology Authors: Lucy Bird Tags: Research Highlight Source Type: research
Regulation of T cell signalling by membrane lipids
Nature Reviews Immunology 18, 219 (2018).
doi:10.1038/nri.2018.9
Author: Wei Wu, Xiaoshan Shi & Chenqi Xu
Nature Reviews Immunology16,
690–70110.1038/nri.2016.103(2016)In the main text of this Review article, ACAT1 was incorrectly defined as 'acetyl-CoA acetyltransferase, mitochondrial'. The correct definition of ACAT1 in this article is 'acyl-CoA cholesterol acyltransferase 1'. Nature Reviews Immunology (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - February 12, 2018 Category: Allergy & Immunology Authors: Wei Wu Xiaoshan Shi Chenqi Xu Tags: Erratum Source Type: research
Immunotherapy: Cytokine boost for CAR T cells
Nature Reviews Immunology 18, 150 (2018).
doi:10.1038/nri.2018.8
Author: Kirsty Minton
Chimeric antigen receptors that provide an antigen-dependent signal 3 to T cells have improved antitumour efficacy. (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - February 12, 2018 Category: Allergy & Immunology Authors: Kirsty Minton Tags: Research Highlight Source Type: research
The tumour glyco-code as a novel immune checkpoint for immunotherapy
Nature Reviews Immunology 18, 204 (2018).
doi:10.1038/nri.2018.3
Authors: Ernesto RodrÍguez, Sjoerd T. T. Schetters & Yvette van Kooyk
Tumour growth is accompanied by tumour evasion of the immune system, a process that is facilitated by immune checkpoint molecules such as programmed cell death protein 1 (PD1). However, the role of tumour glycosylation in immune evasion has mostly been overlooked, despite the fact that (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - February 5, 2018 Category: Allergy & Immunology Authors: Ernesto Rodr Í guez Sjoerd T. T. Schetters Yvette van Kooyk Tags: Perspectives Source Type: research
Altered self: the not-so-neo-antigens
Nature Reviews Immunology 18, 152 (2018).
doi:10.1038/nri.2018.7
Author: Jedd D. Wolchok
Jedd Wolchok describes a 1996 study by Alan Houghton and colleagues that showed how immune tolerance to self antigens on cancer cells could be overcome. (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - February 5, 2018 Category: Allergy & Immunology Authors: Jedd D. Wolchok Tags: Research Highlight Source Type: research
Epigenetic control of CD8+ T cell differentiation
Nature Reviews Immunology 18, 340 (2018).
doi:10.1038/nri.2017.146
Authors: Amanda N. Henning, Rahul Roychoudhuri & Nicholas P. Restifo
Upon stimulation, small numbers of naive CD8+ T cells proliferate and differentiate into a variety of memory and effector cell types. CD8+ T cells can persist for years and kill tumour cells and virally infected cells. The functional and phenotypic changes (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - January 30, 2018 Category: Allergy & Immunology Authors: Amanda N. Henning Rahul Roychoudhuri Nicholas P. Restifo Tags: Review Source Type: research
Passive immunotherapy of viral infections: 'super-antibodies' enter the fray
Nature Reviews Immunology 18, 297 (2018).
doi:10.1038/nri.2017.148
Authors: Laura M. Walker & Dennis R. Burton
Antibodies have been used for more than 100 years in the therapy of infectious diseases, but a new generation of highly potent and/or broadly cross-reactive human monoclonal antibodies (sometimes referred to as 'super-antibodies') offers new opportunities for intervention. The isolation of these antibodies, most of (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - January 30, 2018 Category: Allergy & Immunology Authors: Laura M. Walker Dennis R. Burton Tags: Review Source Type: research
Cancer immunotherapy in 2017: The breakthrough of the microbiota
Nature Reviews Immunology 18, 87 (2018).
doi:10.1038/nri.2018.4
Authors: Guido Kroemer & Laurence Zitvogel
In 2017, epidemiological studies in humans and experiments in mouse models showed that the intestinal microbiota determines the effectiveness of anticancer immunotherapies. As such the microbiota offers new prognostic biomarkers and shows promise as a target for future antineoplastic treatments. (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - January 30, 2018 Category: Allergy & Immunology Authors: Guido Kroemer Laurence Zitvogel Tags: Year in Review Source Type: research
Innate immunity: Sensing bacterial messages
Nature Reviews Immunology 18, 78 (2018).
doi:10.1038/nri.2018.5
Author: Lucy Bird
ER adaptor protein identified as key sensor of the bacterial cyclic dinucleotide c-di-AMP. (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - January 30, 2018 Category: Allergy & Immunology Authors: Lucy Bird Tags: Research Highlight Source Type: research
Tumour immunology: Natural killer cells spy greedy tumours
Nature Reviews Immunology 18, 77 (2018).
doi:10.1038/nri.2018.2
Author: Yvonne Bordon
An NK cell activating receptor can recognize a cellular growth factor to limit tumour cell growth. (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - January 30, 2018 Category: Allergy & Immunology Authors: Yvonne Bordon Tags: Research Highlight Source Type: research
