NF- Îș B, inflammation, immunity and cancer: coming of age
Nature Reviews Immunology 18, 309 (2018).
doi:10.1038/nri.2017.142
Authors: Koji Taniguchi & Michael Karin
Fourteen years have passed since nuclear factor-κB (NF-κB) was first shown to serve as a molecular lynchpin that links persistent infections and chronic inflammation to increased cancer risk. The young field of inflammation and cancer has now come of age, and inflammation has been recognized (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - January 22, 2018 Category: Allergy & Immunology Authors: Koji Taniguchi Michael Karin Tags: Review Source Type: research
Tissue-specific immunopathology during malaria infection
Nature Reviews Immunology 18, 266 (2018).
doi:10.1038/nri.2017.138
Authors: Cevayir Coban, Michelle Sue Jann Lee & Ken J. Ishii
Systemic inflammation mediated by Plasmodium parasites is central to malaria disease and its complications. Plasmodium parasites reside in erythrocytes and can theoretically reach all host tissues via the circulation. However, actual interactions between parasitized erythrocytes and host tissues, along with the consequent damage (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - January 15, 2018 Category: Allergy & Immunology Authors: Cevayir Coban Michelle Sue Jann Lee Ken J. Ishii Tags: Review Source Type: research
Improving immune â vascular crosstalk for cancer immunotherapy
Nature Reviews Immunology 18, 195 (2018).
doi:10.1038/nri.2017.145
Authors: Yuhui Huang, Betty Y. S. Kim, Charles K. Chan, Stephen M. Hahn, Irving L. Weissman & Wen Jiang
The vasculature of tumours is highly abnormal and dysfunctional. Consequently, immune effector cells have an impaired ability to penetrate solid tumours and often exhibit compromised functions. Normalization of the tumour vasculature can enhance tissue perfusion and improve immune effector cell infiltration, leading to immunotherapy potentiation. (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - January 15, 2018 Category: Allergy & Immunology Authors: Yuhui Huang Betty Y. S. Kim Charles K. Chan Stephen M. Hahn Irving L. Weissman Wen Jiang Tags: Perspectives Source Type: research
Innate lymphoid cells: Lipid surveillance by skin ILCs
Nature Reviews Immunology 18, 78 (2018).
doi:10.1038/nri.2018.1
Author: Shimona Starling
Group 2 innate lymphoid cells present endogenous lipids via CD1a to skin-resident T cells (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - January 15, 2018 Category: Allergy & Immunology Authors: Shimona Starling Tags: Research Highlight Source Type: research
HLA variation and disease
Nature Reviews Immunology 18, 325 (2018).
doi:10.1038/nri.2017.143
Authors: Calliope A. Dendrou, Jan Petersen, Jamie Rossjohn & Lars Fugger
Fifty years since the first description of an association between HLA and human disease, HLA molecules have proven to be central to physiology, protective immunity and deleterious, disease-causing autoimmune reactivity. Technological advances have enabled pivotal progress in the determination of the molecular mechanisms that underpin (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - January 2, 2018 Category: Allergy & Immunology Authors: Calliope A. Dendrou Jan Petersen Jamie Rossjohn Lars Fugger Tags: Review Source Type: research
Peptidoglycan recognition by the innate immune system
Nature Reviews Immunology 18, 243 (2018).
doi:10.1038/nri.2017.136
Authors: Andrea J. Wolf & David M. Underhill
The innate immune system recognizes microbial products using germline-encoded receptors that initiate inflammatory responses to infection. The bacterial cell wall component peptidoglycan is a prime example of a conserved pathogen-associated molecular pattern (PAMP) for which the innate immune system has evolved sensing mechanisms. Peptidoglycan is (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - January 2, 2018 Category: Allergy & Immunology Authors: Andrea J. Wolf David M. Underhill Tags: Review Source Type: research
Macrophages and monocytes in 2017: Macrophages and monocytes: of tortoises and hares
Nature Reviews Immunology 18, 85 (2018).
doi:10.1038/nri.2017.158
Author: Steffen Jung
Monocytes and tissue macrophages represent two main branches of the mononuclear phagocyte system, and they have complementary roles during immunological challenges. Several studies published in 2017 highlighted the distinct properties of these two cell types and furthered our understanding of their development and cellular functions. (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - January 2, 2018 Category: Allergy & Immunology Authors: Steffen Jung Tags: Year in Review Source Type: research
Raging evolution of a B cell response to a viral infection
Nature Reviews Immunology 18, 79 (2018).
doi:10.1038/nri.2017.219
Author: Shane Crotty
Shane Crotty discusses a 2013 study by Barton Haynes and colleagues that beautifully illustrates the extreme capacity of a B cell response to evolve in real time to a viral infection. (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - January 2, 2018 Category: Allergy & Immunology Authors: Shane Crotty Tags: Research Highlight Source Type: research
The dawn of vaccines for cancer prevention
Nature Reviews Immunology 18, 183 (2018).
doi:10.1038/nri.2017.140
Author: Olivera J. Finn
An important role of the immune system is in the surveillance for abnormal or transformed cells, which is known as cancer immunosurveillance. Through this process, the first changes to normal tissue homeostasis caused by infectious or other inflammatory insults can be detected by the immune (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - December 27, 2017 Category: Allergy & Immunology Authors: Olivera J. Finn Tags: Review Source Type: research
Neuroimmunology in 2017: The central nervous system: privileged by immune
connections
Nature Reviews Immunology 18, 83 (2018).
doi:10.1038/nri.2017.152
Authors: Jonathan Kipnis & Anthony J. Filiano
Over the past few years, interest in the field of neuroimmunology has expanded
dramatically, thanks largely to new technologies that have advanced our understanding of
the intimate connections between the nervous and immune systems. Here,
we highlight key advances in 2017 that have defined new roles for microglia in brain
maintenance, for cytokines as neuromodulators and for the immune system in peripheral
nerve activity. (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - December 27, 2017 Category: Allergy & Immunology Authors: Jonathan Kipnis Anthony J. Filiano Tags: Year in Review Source Type: research
Are histones real pathogenic agents in sepsis?
Nature Reviews Immunology 18, 148 (2018).
doi:10.1038/nri.2017.157
Authors: Tom van der Poll, Frank L. van de Veerdonk, Brendon P. Scicluna & Mihai G. Netea
We thank Ginsburg and Koren for their brief overview of the potential role of extracellular histones in the pathogenesis of sepsis (Ginsburg, I. & Koren, E. Are histones real pathogenic agents in sepsis? Nat. Rev. Immunol. http://dx.doi.org/10.1038/nri.2017.156 (2017)). Although our Review (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - December 27, 2017 Category: Allergy & Immunology Authors: Tom van der Poll Frank L. van de Veerdonk Brendon P. Scicluna Mihai G. Netea Tags: Reply Source Type: research
Are histones real pathogenic agents in sepsis?
Nature Reviews Immunology 18, 148 (2018).
doi:10.1038/nri.2017.156
Authors: Isaac Ginsburg & Erez Koren
We read with interest the recent Review article by van der Poll et al. (The immunopathology of sepsis and potential therapeutic targets. Nat. Rev. Immunol.17, 407–420 (2017)).This Review article describes various immunopathological aspects of sepsis and relevant targets as (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - December 27, 2017 Category: Allergy & Immunology Authors: Isaac Ginsburg Erez Koren Tags: Correspondence Source Type: research
Immunotherapy: HLA genotype: good to be different
Nature Reviews Immunology 18, 78 (2018).
doi:10.1038/nri.2017.220
Author: Kirsty Minton
HLA class I homozgosity and loss of heterozygosity are associated with poor response to checkpoint blockade therapy. (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - December 27, 2017 Category: Allergy & Immunology Authors: Kirsty Minton Tags: Research Highlight Source Type: research
Response to Orlova et al. â Science not art: statistically sound methods for identifying subsets in multi-dimensional flow and mass cytometry data sets â
Nature Reviews Immunology 18, 78 (2018).
doi:10.1038/nri.2017.151
Authors: Yvan Saeys, Sofie Van Gassen & Bart Lambrecht
“Science is built up of facts, like a house is with stones. But a collection of facts is no more science than a heap of stones is a house.”Henri PoincareUnsupervised learning techniques such as clustering and dimensionality reduction have been widely used in (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - December 22, 2017 Category: Allergy & Immunology Authors: Yvan Saeys Sofie Van Gassen Bart Lambrecht Tags: Reply Source Type: research
Science not art: statistically sound methods for identifying subsets in multi-dimensional flow and mass cytometry data sets
Nature Reviews Immunology 18, 77 (2018).
doi:10.1038/nri.2017.150
Authors: Darya Y. Orlova, Leonore A. Herzenberg & Guenther Walther
Automated approaches that cluster high-dimensional flow and mass cytometry data simultaneously in multiple dimensions, such as those discussed in Saeys et al. (Computational flow cytometry: helping to make sense of high-dimensional immunology data. Nat. Rev. Immunol.16, 449–462 2016), are (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - December 22, 2017 Category: Allergy & Immunology Authors: Darya Y. Orlova Leonore A. Herzenberg Guenther Walther Tags: Correspondence Source Type: research
