Tumour immunology: Cell cycle inhibitors boost tumour immunogenicity
Nature Reviews Immunology 17, 529 (2017).
doi:10.1038/nri.2017.104
Author: Kirsty Minton
Cyclin-dependent kinase inhibitors promote tumour regression by increasing antigen presentation and decreasing immune regulation. (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - August 30, 2017 Category: Allergy & Immunology Authors: Kirsty Minton Tags: Research Highlight Source Type: research
The dichotomy of T helper 17 cells in cancer
Nature Reviews Immunology 17, 592 (2017).
doi:10.1038/nri.2017.93
Author: Lekh N. Dahal
Immunologists have been left with considerable bewilderment by the complexity posed by the brands and flavours of T helper cell subsets. The T helper 17 (TH17) subset is a recent addition and research has focused extensively on basic biology, lineage development, promotion of (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - August 21, 2017 Category: Allergy & Immunology Authors: Lekh N. Dahal Tags: Correspondence Source Type: research
Innate immunity: Nuclear waste ignites cGAS
Nature Reviews Immunology 17, 533 (2017).
doi:10.1038/nri.2017.102
Author: Yvonne Bordon
Cytosolic chromatin activates cGAS and inflammatory gene expression following DNA damage. (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - August 21, 2017 Category: Allergy & Immunology Authors: Yvonne Bordon Tags: Research Highlight Source Type: research
Innate lymphoid cells: major players in inflammatory diseases
Nature Reviews Immunology 17, 665 (2017).
doi:10.1038/nri.2017.86
Authors: Mikaël Ebbo, Adeline Crinier, Frédéric Vély & Eric Vivier
Recent years have seen a marked increase in our understanding of innate lymphoid cells (ILCs). ILCs can be classified into different groups based on their similarity to T cell subsets in terms of their expression of key transcription factors and cytokine production. Various immunological functions (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - August 14, 2017 Category: Allergy & Immunology Authors: Mika ë l Ebbo Adeline Crinier Fr é d é ric V é ly Eric Vivier Tags: Review Source Type: research
Innate immunity: A new way out for lysozyme
Nature Reviews Immunology 17, 532 (2017).
doi:10.1038/nri.2017.98
Author: Shimona Starling
Endoplasmic reticulum stress in Paneth cells induces secretory autophagy of lysozyme. (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - August 14, 2017 Category: Allergy & Immunology Authors: Shimona Starling Tags: Research Highlight Source Type: research
Immunometabolism: NK cell subset expands with your waistline
Nature Reviews Immunology 17, 530 (2017).
doi:10.1038/nri.2017.96
Author: Lucy Bird
A distinct subset of natural killer cells with a myeloid signature is associated with metainflammation. (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - August 14, 2017 Category: Allergy & Immunology Authors: Lucy Bird Tags: Research Highlight Source Type: research
Antibodies: Herd immunity
Nature Reviews Immunology 17, 530 (2017).
doi:10.1038/nri.2017.94
Author: Yvonne Bordon
Broadly neutralizing antibodies against HIV can be rapidly generated by immunizing cows. (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - August 14, 2017 Category: Allergy & Immunology Authors: Yvonne Bordon Tags: Research Highlight Source Type: research
Single-cell RNA sequencing to explore immune cell heterogeneity
Nature Reviews Immunology 18, 35 (2018).
doi:10.1038/nri.2017.76
Authors: Efthymia Papalexi & Rahul Satija
Advances in single-cell RNA sequencing (scRNA-seq) have allowed for comprehensive analysis of the immune system. In this Review, we briefly describe the available scRNA-seq technologies together with their corresponding strengths and weaknesses. We discuss in depth how scRNA-seq can be used to deconvolve immune system (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - August 7, 2017 Category: Allergy & Immunology Authors: Efthymia Papalexi Rahul Satija Tags: Review Source Type: research
Mechanisms and consequences of diversity-generating immune strategies
Nature Reviews Immunology 17, 719 (2017).
doi:10.1038/nri.2017.78
Authors: Edze R. Westra, David Sünderhauf, Mariann Landsberger & Angus Buckling
Species from all five kingdoms of life have evolved sophisticated mechanisms to generate diversity in genes that are involved in host–pathogen interactions, conferring reduced levels of parasitism to both individuals and populations. Here, we highlight unifying concepts that underpin these evolutionarily unrelated diversity-generating mechanisms (DGMs). (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - August 7, 2017 Category: Allergy & Immunology Authors: Edze R. Westra David S ü nderhauf Mariann Landsberger Angus Buckling Tags: Perspectives Source Type: research
Mucosal immunology: Eye spy a protective commensal
Nature Reviews Immunology 17, 531 (2017).
doi:10.1038/nri.2017.92
Author: Shimona Starling
A candidate ocular commensal organism isolated from mice drives ocular immune responses and protects against infection with pathogens. (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - August 7, 2017 Category: Allergy & Immunology Authors: Shimona Starling Tags: Research Highlight Source Type: research
The regulation of immune tolerance by FOXP3
Nature Reviews Immunology 17, 703 (2017).
doi:10.1038/nri.2017.75
Authors: Ling Lu, Joseph Barbi & Fan Pan
The proper restraint of the destructive potential of the immune system is essential for maintaining health. Regulatory T (Treg) cells ensure immune homeostasis through their defining ability to suppress the activation and function of other leukocytes. The expression of the transcription factor forkhead (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - July 31, 2017 Category: Allergy & Immunology Authors: Ling Lu Joseph Barbi Fan Pan Tags: Review Source Type: research
Mechanical forces in the immune system
Nature Reviews Immunology 17, 679 (2017).
doi:10.1038/nri.2017.74
Author: Morgan Huse
Leukocytes can completely reorganize their cytoskeletal architecture within minutes. This structural plasticity, which facilitates their migration and communicative function, also enables them to exert a substantial amount of mechanical force against the extracellular matrix and the surfaces of interacting cells. In recent years, it has (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - July 31, 2017 Category: Allergy & Immunology Authors: Morgan Huse Tags: Review Source Type: research
Turning the light on
Nature Reviews Immunology 17, 593 (2017).
doi:10.1038/nri.2017.85
Author: Richard Locksley
Richard Locksley describes a 2004 study by Margaret McFall-Ngai and colleagues that showed the role of bacterial pattern recognition in driving tissue homeostasis and function. (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - July 31, 2017 Category: Allergy & Immunology Authors: Richard Locksley Tags: Research Highlight Source Type: research
The pros and cons of dying tumour cells in adaptive immune responses
Nature Reviews Immunology 17, 591 (2017).
doi:10.1038/nri.2017.87
Authors: Xiaochen Wang, Xiao-Jie Lu & Beicheng Sun
Therapeutics based upon using the adaptive immune system to fight against tumours have become the most promising in the field. Increasing evidence has shown that multiform cell death-mediated events play vital roles in regulating adaptive immune responses within tumours, thus providing potential antitumour therapeutic targets. (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - July 31, 2017 Category: Allergy & Immunology Authors: Xiaochen Wang Xiao-Jie Lu Beicheng Sun Tags: Correspondence Source Type: research
Tumour vaccines: Personal training by vaccination
Nature Reviews Immunology 17, 468 (2017).
doi:10.1038/nri.2017.88
Author: Ulrike Harjes
Two groups have shown that personalized, neoantigen-based tumour vaccines elicit effective T cell responses in patients with advanced melanoma, leading to favourable clinical outcomes. Combination with checkpoint blockade can be of additional benefit. (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - July 27, 2017 Category: Allergy & Immunology Authors: Ulrike Harjes Tags: Research Highlight Source Type: research
