Programmed cell death as a defence against infection
Nature Reviews Immunology 17, 151 (2017).
doi:10.1038/nri.2016.147
Authors: Ine Jorgensen, Manira Rayamajhi & Edward A. Miao
Eukaryotic cells can die from physical trauma, which results in necrosis. Alternatively, they can die through programmed cell death upon the stimulation of specific signalling pathways. In this Review, we discuss the role of different cell death pathways in innate immune defence against bacterial and (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - January 30, 2017 Category: Allergy & Immunology Authors: Ine Jorgensen Manira Rayamajhi Edward A. Miao Tags: Review Source Type: research
Multi-dimensional control of clonal evolution
Nature Reviews Immunology 17, 149 (2017).
doi:10.1038/nri.2017.6
Author: Michael McHeyzer-Williams
Michael McHeyzer-Williams describes a 1998 study by Avi Kupfer and colleagues that transformed the view of cognate T helper cell–B cell crosstalk. (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - January 30, 2017 Category: Allergy & Immunology Authors: Michael McHeyzer-Williams Tags: Research Highlight Source Type: research
T cells: Something to chew on
Nature Reviews Immunology 17, 81 (2017).
doi:10.1038/nri.2017.4
Author: Lucy Bird
Chewing induces the accumulation of T helper 17 cells in the mouth. (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - January 30, 2017 Category: Allergy & Immunology Authors: Lucy Bird Tags: Research Highlight Source Type: research
Autoimmune diseases: Inhibitor of adaptor protein shows self-antigen selectivity
Nature Reviews Immunology 17, 80 (2017).
doi:10.1038/nri.2017.5
Author: Alexandra Flemming
A T cell receptor signalling inhibitor shows efficacy in autoimmune diseases without affecting immune responses to pathogens. (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - January 30, 2017 Category: Allergy & Immunology Authors: Alexandra Flemming Tags: Research Highlight Source Type: research
Immunobiology of Ebola and Lassa virus infections
Nature Reviews Immunology 17, 195 (2017).
doi:10.1038/nri.2016.138
Authors: Joseph B. Prescott, Andrea Marzi, David Safronetz, Shelly J. Robertson, Heinz Feldmann & Sonja M. Best
Two of the most important contemporary emerging viruses that affect human health in Africa are Ebola virus (EBOV) and Lassa virus (LASV). The 2013–2016 West African outbreak of EBOV was responsible for more than 11,000 deaths, primarily in Guinea, Sierra Leone and Liberia. LASV is (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - January 22, 2017 Category: Allergy & Immunology Authors: Joseph B. Prescott Andrea Marzi David Safronetz Shelly J. Robertson Heinz Feldmann Sonja M. Best Tags: Review Source Type: research
Antibody responses: A thymic niche for plasma cells
Nature Reviews Immunology 17, 78 (2017).
doi:10.1038/nri.2017.2
Author: Yvonne Bordon
Plasma cells accumulate in the ageing thymus and may provide protection against viral infections. (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - January 22, 2017 Category: Allergy & Immunology Authors: Yvonne Bordon Tags: Research Highlight Source Type: research
Inflammation: Inflammasome-related ageing
Nature Reviews Immunology 17, 77 (2017).
doi:10.1038/nri.2017.3
Author: Kirsty Minton
Increased expression of inflammasome-related gene modules in older individuals correlates with nucleotide metabolism dysfunction, IL-1β production and cardiovascular disease. (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - January 22, 2017 Category: Allergy & Immunology Authors: Kirsty Minton Tags: Research Highlight Source Type: research
Disease tolerance and immunity in host protection against infection
Nature Reviews Immunology 17, 83 (2017).
doi:10.1038/nri.2016.136
Authors: Miguel P. Soares, Luis Teixeira & Luis F. Moita
The immune system probably evolved to limit the negative effects exerted by pathogens on host homeostasis. This defence strategy relies on the concerted action of innate and adaptive components of the immune system, which sense and target pathogens for containment, destruction or expulsion. Resistance to (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - January 2, 2017 Category: Allergy & Immunology Authors: Miguel P. Soares Luis Teixeira Luis F. Moita Tags: Review Source Type: research
Allergy: Neonatal IL-33 drives allergy
Nature Reviews Immunology 17, 80 (2017).
doi:10.1038/nri.2016.149
Author: Lydia Shipman
Interleukin-33 is a key driver of type 2 immunity in the developing neonatal lung of mice both in the steady state and in response to allergen exposure. (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - January 2, 2017 Category: Allergy & Immunology Authors: Lydia Shipman Tags: Research Highlight Source Type: research
Tumour immunology: NLRC3 inhibits mTOR in colorectal cancer
Nature Reviews Immunology 17, 79 (2017).
doi:10.1038/nri.2016.152
Author: Olive Leavy
NLRC3 protects against colorectal cancer by suppressing the proliferation of intestinal epithelial cells through inhibition of the PI3K–AKT–mTOR pathway. (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - January 2, 2017 Category: Allergy & Immunology Authors: Olive Leavy Tags: Research Highlight Source Type: research
Immunometabolism: Complex metabolic responses to microbial stimuli
Nature Reviews Immunology 17, 78 (2017).
doi:10.1038/nri.2016.148
Author: Elisabeth Kugelberg
Different microbial stimuli lead to specific metabolic programmes in activated human monocytes. (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - January 2, 2017 Category: Allergy & Immunology Authors: Elisabeth Kugelberg Tags: Research Highlight Source Type: research
Reply: The complement system is also important in immunogenic cell death
Nature Reviews Immunology 17, 143 (2017).
doi:10.1038/nri.2016.143
Authors: Lorenzo Galluzzi, Aitziber Buqué, Oliver Kepp, Laurence Zitvogel & Guido Kroemer
We have recently reviewed current knowledge on the mechanisms that underlie immunogenic cell death (ICD) in the context of cancer and infectious diseases, the capacity of ICD to elicit an adaptive immune response in the absence of exogenous adjuvants, and the pathophysiological relevance of this (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - December 27, 2016 Category: Allergy & Immunology Authors: Lorenzo Galluzzi Aitziber Buqu é Oliver Kepp Laurence Zitvogel Guido Kroemer Tags: Correspondence Source Type: research
The complement system is also important in immunogenic cell death
Nature Reviews Immunology 17, 143 (2017).
doi:10.1038/nri.2016.142
Authors: Junfei Jin & Songqing He
We recently came across a Review (Nat. Rev. Immunol. doi: 10.1038/nri.2016.107 (2016)) published in your distinguished journal. We completely agree with the authors' statement that immunogenic cell death (ICD), whether occurring in cancer cells or pathogen infection, requires the two key (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - December 27, 2016 Category: Allergy & Immunology Authors: Junfei Jin Songqing He Tags: Correspondence Source Type: research
Mechanisms of immunomodulation by mammalian and viral decoy receptors: insights from structures
Nature Reviews Immunology 17, 112 (2017).
doi:10.1038/nri.2016.134
Authors: Jan Felix & Savvas N. Savvides
Immune responses are regulated by effector cytokines and chemokines that signal through cell surface receptors. Mammalian decoy receptors — which are typically soluble or inactive versions of cell surface receptors or soluble protein modules termed binding proteins — modulate and antagonize signalling by canonical effector–receptor (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - December 27, 2016 Category: Allergy & Immunology Authors: Jan Felix Savvas N. Savvides Tags: Review Source Type: research
T cells: Sorting memories
Nature Reviews Immunology 17, 2 (2017).
doi:10.1038/nri.2016.146
Author: Lucy Bird
Expression of CX3CR1 defines a new memory T cell subset that surveys peripheral tissues. (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - December 22, 2016 Category: Allergy & Immunology Authors: Lucy Bird Tags: Research Highlight Source Type: research
