Tumour immunology: Immune atlas sheds light on anticancer responses
Nature Reviews Immunology 17, 347 (2017).
doi:10.1038/nri.2017.59
Author: Alexandra Flemming
Multiscale immune profiling strategies facilitate unprecedented insights into the subtypes and composition of immune cells in the tumour microenvironment. (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - May 26, 2017 Category: Allergy & Immunology Authors: Alexandra Flemming Tags: Research Highlight Source Type: research
Asthma and allergy: The NET effect of respiratory viruses
Nature Reviews Immunology 17, 346 (2017).
doi:10.1038/nri.2017.60
Author: Yvonne Bordon
Rhinovirus infections exacerbate asthma by inducing the release of neutrophil extracellular traps. (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - May 26, 2017 Category: Allergy & Immunology Authors: Yvonne Bordon Tags: Research Highlight Source Type: research
Immune regulation: IL-10 targets macrophage metabolism
Nature Reviews Immunology 17, 345 (2017).
doi:10.1038/nri.2017.57
Author: Kirsty Minton
The anti-inflammatory effects of IL-10 involve mTORC1-regulated metabolic and autophagic pathways in macrophages. (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - May 26, 2017 Category: Allergy & Immunology Authors: Kirsty Minton Tags: Research Highlight Source Type: research
Early life factors that affect allergy development
Nature Reviews Immunology 17, 518 (2017).
doi:10.1038/nri.2017.39
Authors: Lisa A. Reynolds & B. Brett Finlay
The incidence of allergic disease continues to rise in industrialized countries. The rapid increase in the incidence of allergic disease throughout the past half century suggests that recently altered environmental factors are driving allergy development. Accumulating evidence suggests that environmental experiences that occur during the (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - May 15, 2017 Category: Allergy & Immunology Authors: Lisa A. Reynolds B. Brett Finlay Tags: Review Source Type: research
Neuroimmunology: Macrophages help you burn energy
Nature Reviews Immunology 17, 346 (2017).
doi:10.1038/nri.2017.56
Author: Lucy Bird
Macrophages in brown adipose tissue support sympathetic innervation to ensure proper homeostatic energy expenditure. (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - May 15, 2017 Category: Allergy & Immunology Authors: Lucy Bird Tags: Research Highlight Source Type: research
Immunological implications of pregnancy-induced microchimerism
Nature Reviews Immunology 17, 483 (2017).
doi:10.1038/nri.2017.38
Authors: Jeremy M. Kinder, Ina A. Stelzer, Petra C. Arck & Sing Sing Way
Immunological identity is traditionally defined by genetically encoded antigens, with equal maternal and paternal contributions as a result of Mendelian inheritance. However, vertically transferred maternal cells also persist in individuals at very low levels throughout postnatal development. Reciprocally, mothers are seeded during pregnancy with genetically (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - May 8, 2017 Category: Allergy & Immunology Authors: Jeremy M. Kinder Ina A. Stelzer Petra C. Arck Sing Sing Way Tags: Review Source Type: research
Reply: Immunosuppressive cell death in cancer
Nature Reviews Immunology 17, 402 (2017).
doi:10.1038/nri.2017.48
Authors: Lorenzo Galluzzi, Aitziber Buqué, Oliver Kepp, Laurence Zitvogel & Guido Kroemer
In our recent Review (Immunogenic cell death in cancer and infectious disease. Nat. Rev. Immunol.17, 97–111 (2017)), we discussed the molecular and cellular processes through which the death of infected and malignant cells can initiate an adaptive immune response against (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - May 8, 2017 Category: Allergy & Immunology Authors: Lorenzo Galluzzi Aitziber Buqu é Oliver Kepp Laurence Zitvogel Guido Kroemer Tags: Correspondence Source Type: research
Immunosuppressive cell death in cancer
Nature Reviews Immunology 17, 401 (2017).
doi:10.1038/nri.2017.46
Authors: Jiajie Hou, Tim F. Greten & Qiang Xia
Harnessing the fundamental machinery of the immune system provides an opportunity to cure cancer, and this has led oncologists to turn their attention to the interface between therapeutic strategies, cancer cell death and the immunological consequences. In their recent Review article (Immunogenic cell death (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - May 8, 2017 Category: Allergy & Immunology Authors: Jiajie Hou Tim F. Greten Qiang Xia Tags: Correspondence Source Type: research
Antigen-inexperienced memory CD8+ T cells: where they come from and why we need them
Nature Reviews Immunology 17, 391 (2017).
doi:10.1038/nri.2017.34
Authors: Jason T. White, Eric W. Cross & Ross M. Kedl
Memory-phenotype CD8+ T cells exist in substantial numbers within hosts that have not been exposed to either foreign antigen or overt lymphopenia. These antigen-inexperienced memory-phenotype T cells can be divided into two major subsets: 'innate memory' T cells and 'virtual memory' T cells. (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - May 8, 2017 Category: Allergy & Immunology Authors: Jason T. White Eric W. Cross Ross M. Kedl Tags: Perspectives Source Type: research
Medullary Thymic epithelial cell progenitors: hidden in plain sight
Nature Reviews Immunology 17, 348 (2017).
doi:10.1038/nri.2017.27
Author: Graham Anderson
Graham Anderson describes a 2001 study by Rodewald and colleagues that provided the first experimental evidence for thymic epithelial cell progenitors. (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - May 8, 2017 Category: Allergy & Immunology Authors: Graham Anderson Tags: Research Highlight Source Type: research
Does niche competition determine the origin of tissue-resident macrophages?
Nature Reviews Immunology 17, 451 (2017).
doi:10.1038/nri.2017.42
Authors: Martin Guilliams & Charlotte L. Scott
Most tissue-resident macrophages are derived from embryonic precursors but, under certain circumstances, circulating monocytes can differentiate into self-maintaining tissue-resident macrophages that resemble their embryonic counterparts. In this Opinion article, we propose that distinct macrophage precursors have an almost identical potential to develop into resident macrophages (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - May 2, 2017 Category: Allergy & Immunology Authors: Martin Guilliams Charlotte L. Scott Tags: Perspectives Source Type: research
BACH transcription factors in innate and adaptive immunity
Nature Reviews Immunology 17, 437 (2017).
doi:10.1038/nri.2017.26
Authors: Kazuhiko Igarashi, Tomohiro Kurosaki & Rahul Roychoudhuri
BTB and CNC homology (BACH) proteins are transcriptional repressors of the basic region leucine zipper (bZIP) transcription factor family. Recent studies indicate widespread roles of BACH proteins in controlling the development and function of the innate and adaptive immune systems, including the differentiation of effector (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - May 2, 2017 Category: Allergy & Immunology Authors: Kazuhiko Igarashi Tomohiro Kurosaki Rahul Roychoudhuri Tags: Review Source Type: research
Multi-receptor detection of individual bacterial products by the innate immune system
Nature Reviews Immunology 17, 376 (2017).
doi:10.1038/nri.2017.25
Authors: Karen J. Kieser & Jonathan C. Kagan
The receptors of the innate immune system detect specific microbial ligands to promote effective inflammatory and adaptive immune responses. Although this idea is well appreciated, studies in recent years have highlighted the complexity of innate immune detection, with multiple host receptors recognizing the same microbial (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - May 2, 2017 Category: Allergy & Immunology Authors: Karen J. Kieser Jonathan C. Kagan Tags: Review Source Type: research
Cytokines: Oncostatin M – a new target in IBD?
Nature Reviews Immunology 17, 280 (2017).
doi:10.1038/nri.2017.45
Author: Yvonne Bordon
Oncostatin M promotes intestinal inflammation and can predict responsiveness to anti-TNF therapy in patients with inflammatory bowel diseases. (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - April 26, 2017 Category: Allergy & Immunology Authors: Yvonne Bordon Tags: Research Highlight Source Type: research
Insect Immunity: Mechanism of adaptive immunity found in the fruitfly
Nature Reviews Immunology 17, 278 (2017).
doi:10.1038/nri.2017.44
Author: Alexandra Flemming
Haemocytes in Drosophila melanogaster facilitate antiviral immunity by amplifying and systemically disseminating RNA interference-mediated responses via exosome-like vesicles. Moreover, they allow for immune memory, akin to adaptive immune responses in mammals. (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - April 26, 2017 Category: Allergy & Immunology Authors: Alexandra Flemming Tags: Research Highlight Source Type: research
