Unique aspects of the perinatal immune system
Nature Reviews Immunology 17, 495 (2017).
doi:10.1038/nri.2017.54
Authors: Xiaoming Zhang, Dania Zhivaki & Richard Lo-Man
The early stages of life are associated with increased susceptibility to infection, which is in part due to an ineffective immune system. In the context of infection, the immune system must be stimulated to provide efficient protection while avoiding insufficient or excessive activation. Yet, in (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - June 19, 2017 Category: Allergy & Immunology Authors: Xiaoming Zhang Dania Zhivaki Richard Lo-Man Tags: Review Source Type: research
The unique immunological and microbial aspects of pregnancy
Nature Reviews Immunology 17, 469 (2017).
doi:10.1038/nri.2017.64
Authors: Gil Mor, Paulomi Aldo & Ayesha B. Alvero
The comparison of the immunological state of pregnancy to an immunosuppressed host–graft model continues to lead research and clinical practice to ill-defined approaches. This Review discusses recent evidence that supports the idea that immunological responses at the receptive maternal–fetal interface are not simply suppressed but (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - June 19, 2017 Category: Allergy & Immunology Authors: Gil Mor Paulomi Aldo Ayesha B. Alvero Tags: Review Source Type: research
Tumour Immunology: LAP targeting reduces tolerogenic cells in cancer
Nature Reviews Immunology 17, 402 (2017).
doi:10.1038/nri.2017.65
Author: Alexandra Flemming
Anti-LAP antibodies show promising anticancer properties. (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - June 19, 2017 Category: Allergy & Immunology Authors: Alexandra Flemming Tags: Research Highlight Source Type: research
Regulatory T cells: Subset-specific suppression
Nature Reviews Immunology 17, 401 (2017).
doi:10.1038/nri.2017.68
Author: Kirsty Minton
T-bet+ regulatory T cells form a stable subset with specific suppressive activity towards T-bet+ effector T cells. (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - June 19, 2017 Category: Allergy & Immunology Authors: Kirsty Minton Tags: Research Highlight Source Type: research
Fungal dysbiosis: immunity and interactions at mucosal barriers
Nature Reviews Immunology 17, 635 (2017).
doi:10.1038/nri.2017.55
Authors: Iliyan D. Iliev & Irina Leonardi
Fungi and mammals share a co-evolutionary history and are involved in a complex web of interactions. Studies focused on commensal bacteria suggest that pathological changes in the microbiota, historically known as dysbiosis, are at the root of many inflammatory diseases of non-infectious origin. However, the (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - June 12, 2017 Category: Allergy & Immunology Authors: Iliyan D. Iliev Irina Leonardi Tags: Review Source Type: research
Adult haematopoietic stem cell niches
Nature Reviews Immunology 17, 573 (2017).
doi:10.1038/nri.2017.53
Authors: Genevieve M. Crane, Elise Jeffery & Sean J. Morrison
Stem cell niches are specialized microenvironments that promote the maintenance of stem cells and regulate their function. Recent advances have improved our understanding of the niches that maintain adult haematopoietic stem cells (HSCs). These advances include new markers for HSCs and niche cells, systematic analyses (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - June 12, 2017 Category: Allergy & Immunology Authors: Genevieve M. Crane Elise Jeffery Sean J. Morrison Tags: Review Source Type: research
How nutrition and the maternal microbiota shape the neonatal immune system
Nature Reviews Immunology 17, 508 (2017).
doi:10.1038/nri.2017.58
Authors: Andrew J. Macpherson, Mercedes Gomez de Agüero & Stephanie C. Ganal-Vonarburg
The mucosal surfaces of mammals are densely colonized with microorganisms that are commonly referred to as the commensal microbiota. It is believed that the fetus in utero is sterile and that colonization with microorganisms starts only after birth. Nevertheless, the unborn fetus is exposed (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - June 12, 2017 Category: Allergy & Immunology Authors: Andrew J. Macpherson Mercedes Gomez de Ag ü ero Stephanie C. Ganal-Vonarburg Tags: Review Source Type: research
Transcriptional determination and functional specificity of myeloid cells: making sense of diversity
Nature Reviews Immunology 17, 595 (2017).
doi:10.1038/nri.2017.51
Authors: Silvia Monticelli & Gioacchino Natoli
Early responses to invading pathogens and to non-microbial danger signals are mediated by different innate immune and parenchymal tissue cells, which are able to respond to a variety of pathogen- and danger-associated molecular patterns. In most if not all instances, innate immune responses to a (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - June 5, 2017 Category: Allergy & Immunology Authors: Silvia Monticelli Gioacchino Natoli Tags: Review Source Type: research
The non-canonical NF- κ B pathway in immunity and inflammation
Nature Reviews Immunology 17, 545 (2017).
doi:10.1038/nri.2017.52
Author: Shao-Cong Sun
The nuclear factor-κB (NF-κB) family of transcription factors is activated by canonical and non-canonical signalling pathways, which differ in both signalling components and biological functions. Recent studies have revealed important roles for the non-canonical NF-κB pathway in regulating different aspects of immune functions. Defects in (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - June 5, 2017 Category: Allergy & Immunology Authors: Shao-Cong Sun Tags: Review Source Type: research
Chemokines in the cancer microenvironment and their relevance in cancer immunotherapy
Nature Reviews Immunology 17, 559 (2017).
doi:10.1038/nri.2017.49
Authors: Nisha Nagarsheth, Max S. Wicha & Weiping Zou
The tumour microenvironment is the primary location in which tumour cells and the host immune system interact. Different immune cell subsets are recruited into the tumour microenvironment via interactions between chemokines and chemokine receptors, and these populations have distinct effects on tumour progression and therapeutic (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - May 30, 2017 Category: Allergy & Immunology Authors: Nisha Nagarsheth Max S. Wicha Weiping Zou Tags: Review Source Type: research
The dichotomous nature of T helper 17 cells
Nature Reviews Immunology 17, 535 (2017).
doi:10.1038/nri.2017.50
Authors: Brigitta Stockinger & Sara Omenetti
T helper 17 (TH17) cells have been extensively studied since their discovery 10 years ago, primarily because of their known pathogenic role in many inflammatory diseases. Substantial progress has been made in understanding their development, regulation and functional activities, and genome-wide transcriptomic analysis (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - May 30, 2017 Category: Allergy & Immunology Authors: Brigitta Stockinger Sara Omenetti Tags: Review Source Type: research
T cell – B cell collaboration
Nature Reviews Immunology 17, 532 (2017).
doi:10.1038/nri.2017.62
Author: Jonathan Sprent
Jonathan Sprent describes a 1968 study by Graham Mitchell and Jacques Miller that showed the requirement for T cell–B cell collaboration for antibody production. (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - May 30, 2017 Category: Allergy & Immunology Authors: Jonathan Sprent Tags: Research Highlight Source Type: research
NK cell allorecognition
Nature Reviews Immunology 17, 466 (2017).
doi:10.1038/nri.2017.23
Author: Ashley Moffett
Ashley Moffett describes a 1995 paper by Colonna and Samaridis that provided the stiumulus to understanding the link between NK cells and pre-eclampsia. (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - May 30, 2017 Category: Allergy & Immunology Authors: Ashley Moffett Tags: Research Highlight Source Type: research
Neuroendrocrine effects on autoimmunity
Nature Reviews Immunology 17, 405 (2017).
doi:10.1038/nri.2017.47
Author: Anne Cooke
Anne Cooke discusses a 1989 paper by Don Mason and colleagues that described a role for adrenal corticosteroids in modulating autoimmune pathology. (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - May 30, 2017 Category: Allergy & Immunology Authors: Anne Cooke Tags: Research Highlight Source Type: research
Tumour immunology: Platelets — a new target in cancer immunotherapy?
Nature Reviews Immunology 17, 348 (2017).
doi:10.1038/nri.2017.61
Author: Yvonne Bordon
Activation of TGFβ by platelets limits the efficacy of anti-tumour T cell responses. (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - May 26, 2017 Category: Allergy & Immunology Authors: Yvonne Bordon Tags: Research Highlight Source Type: research
