Inflammation: Inflammatory memory is skin deep
Nature Reviews Immunology 17, 731 (2017).
doi:10.1038/nri.2017.127
Author: Yvonne Bordon
Skin epithelial stem cells show inflammatory memory, which enhances their response to tissue damage. (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - November 7, 2017 Category: Allergy & Immunology Authors: Yvonne Bordon Tags: Research Highlight Source Type: research
Immunometabolism: T cells activate the fear
Nature Reviews Immunology 17, 730 (2017).
doi:10.1038/nri.2017.126
Author: Shimona Starling
T cell activation is associated with a depletion of amino acids and neurotransmitters and may result in behavioural changes (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - November 7, 2017 Category: Allergy & Immunology Authors: Shimona Starling Tags: Research Highlight Source Type: research
TH2 cell development and function
Nature Reviews Immunology 18, 121 (2018).
doi:10.1038/nri.2017.118
Authors: Jennifer A. Walker & Andrew N. J. McKenzie
T helper 2 (TH2) cells orchestrate protective type 2 immune responses, such as those that target helminths and facilitate tissue repair, but also contribute to chronic inflammatory diseases, such as asthma and allergy. Here, we review recent insights into how diverse molecular signals (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - October 30, 2017 Category: Allergy & Immunology Authors: Jennifer A. Walker Andrew N. J. McKenzie Tags: Review Source Type: research
New beginnings
Nature Reviews Immunology 17, 732 (2017).
doi:10.1038/nri.2017.91
Author: Florent Ginhoux
Florent Ginhoux reflects on a 2002 paper by Merad and colleagues that challenged the dogma that adult Langerhans cells arise from blood-circulating precursors. (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - October 30, 2017 Category: Allergy & Immunology Authors: Florent Ginhoux Tags: Research Highlight Source Type: research
Cytokines: The inflamed heart
Nature Reviews Immunology 17, 732 (2017).
doi:10.1038/nri.2017.135
Author: Lucy Bird
Type I interferons, induced by DNA released from ischaemic cardiomyocytes, drive inflammation after myocardial infarction. (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - October 27, 2017 Category: Allergy & Immunology Authors: Lucy Bird Tags: Research Highlight Source Type: research
Innate immunity: Fibrinolytic and innate systems collide
Nature Reviews Immunology 17, 663 (2017).
doi:10.1038/nri.2017.124
Author: Mina Razzak
Nuclear factor of activated T cells (NFAT) regulates IFNγ production in natural killer cells and controls fibrinolytic processes required to clear skin infections. (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - October 27, 2017 Category: Allergy & Immunology Authors: Mina Razzak Tags: Research Highlight Source Type: research
Regulatory T Cells: The IL-2 gauge
Nature Reviews Immunology 17, 662 (2017).
doi:10.1038/nri.2017.123
Author: Lucy Bird
T follicular regulatory cells arise once infection resolves and IL-2 levels wane to prevent the outgrowth of self-reactive B cells. (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - October 27, 2017 Category: Allergy & Immunology Authors: Lucy Bird Tags: Research Highlight Source Type: research
Neutrophils: Neutrophil differentiation is autophagy dependent
Nature Reviews Immunology 17, 662 (2017).
doi:10.1038/nri.2017.122
Author: Peter Sidaway
Metabolism of free fatty acids by cell-intrinsic autophagy is an essential component of neutrophil differentiation. (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - October 27, 2017 Category: Allergy & Immunology Authors: Peter Sidaway Tags: Research Highlight Source Type: research
Beyond binding: antibody effector functions in infectious diseases
Nature Reviews Immunology 18, 46 (2018).
doi:10.1038/nri.2017.106
Authors: Lenette L. Lu, Todd J. Suscovich, Sarah M. Fortune & Galit Alter
Antibodies play an essential role in host defence against pathogens by recognizing microorganisms or infected cells. Although preventing pathogen entry is one potential mechanism of protection, antibodies can control and eradicate infections through a variety of other mechanisms. In addition to binding and directly neutralizing (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - October 24, 2017 Category: Allergy & Immunology Authors: Lenette L. Lu Todd J. Suscovich Sarah M. Fortune Galit Alter Tags: Review Source Type: research
The hygiene hypothesis in autoimmunity: the role of pathogens and commensals
Nature Reviews Immunology 18, 105 (2018).
doi:10.1038/nri.2017.111
Author: Jean-François Bach
The incidence of autoimmune diseases has been steadily rising. Concomitantly, the incidence of most infectious diseases has declined. This observation gave rise to the hygiene hypothesis, which postulates that a reduction in the frequency of infections contributes directly to the increase in the frequency of (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - October 16, 2017 Category: Allergy & Immunology Authors: Jean-Fran รง ois Bach Tags: Review Source Type: research
Immune tolerance: A mother's greatest gift is TIM3
Nature Reviews Immunology 17, 662 (2017).
doi:10.1038/nri.2017.120
Author: Shimona Starling
Maternal–fetal tolerance is promoted by TIM3 signalling in peripheral natural killer cells. (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - October 16, 2017 Category: Allergy & Immunology Authors: Shimona Starling Tags: Research Highlight Source Type: research
Neuroimmunology: ILC2s touch a nerve
Nature Reviews Immunology 17, 661 (2017).
doi:10.1038/nri.2017.119
Author: Yvonne Bordon
Mucosal neurons activate ILC2s and drive type 2 inflammation by secreting neuromedin U. (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - October 16, 2017 Category: Allergy & Immunology Authors: Yvonne Bordon Tags: Research Highlight Source Type: research
Neutrophil extracellular traps in immunity and disease
Nature Reviews Immunology 18, 134 (2018).
doi:10.1038/nri.2017.105
Author: Venizelos Papayannopoulos
Neutrophils are innate immune phagocytes that have a central role in immune defence. Our understanding of the role of neutrophils in pathogen clearance, immune regulation and disease pathology has advanced dramatically in recent years. Web-like chromatin structures known as neutrophil extracellular traps (NETs) have been (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - October 9, 2017 Category: Allergy & Immunology Authors: Venizelos Papayannopoulos Tags: Review Source Type: research
Immune checkpoint blockade in infectious diseases
Nature Reviews Immunology 18, 91 (2018).
doi:10.1038/nri.2017.112
Authors: Michelle N. Wykes & Sharon R. Lewin
The upregulation of immune checkpoint molecules, such as programmed cell death protein 1 (PD1) and cytotoxic T lymphocyte antigen 4 (CTLA4), on immune cells occurs during acute infections, such as malaria, as well as during chronic persistent viral infections, including HIV and hepatitis B virus. (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - October 9, 2017 Category: Allergy & Immunology Authors: Michelle N. Wykes Sharon R. Lewin Tags: Review Source Type: research
Regulation of immunity and inflammation by hypoxia in immunological niches
Nature Reviews Immunology 17, 774 (2017).
doi:10.1038/nri.2017.103
Authors: Cormac T. Taylor & Sean P. Colgan
Immunological niches are focal sites of immune activity that can have varying microenvironmental features. Hypoxia is a feature of physiological and pathological immunological niches. The impact of hypoxia on immunity and inflammation can vary depending on the microenvironment and immune processes occurring in a given (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - October 3, 2017 Category: Allergy & Immunology Authors: Cormac T. Taylor Sean P. Colgan Tags: Review Source Type: research
