Immune checkpoint blockade in infectious diseases

Nature Reviews Immunology 18, 91 (2018). doi:10.1038/nri.2017.112 Authors: Michelle N. Wykes & Sharon R. Lewin The upregulation of immune checkpoint molecules, such as programmed cell death protein 1 (PD1) and cytotoxic T lymphocyte antigen 4 (CTLA4), on immune cells occurs during acute infections, such as malaria, as well as during chronic persistent viral infections, including HIV and hepatitis B virus.
Source: Nature Reviews Immunology - Category: Allergy & Immunology Authors: Tags: Review Source Type: research