Macrophages: Granuloma macrophage differentiation
Nature Reviews Immunology 16, 718 (2016).
doi:10.1038/nri.2016.132
Author: Kirsty Minton
Multinuclear granuloma macrophages arise through a distinct differentiation pathway mediated by chronic TLR2 signalling, rather than by cell fusion. (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - November 24, 2016 Category: Allergy & Immunology Authors: Kirsty Minton Tags: Research Highlight Source Type: research
Infection: Zika virus: end of transmission?
Nature Reviews Immunology 16, 718 (2016).
doi:10.1038/nri.2016.131
Author: Yvonne Bordon
Broadly neutralizing human antibodies for Zika virus protect adult mice and prevent maternal–fetal transmission. (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - November 24, 2016 Category: Allergy & Immunology Authors: Yvonne Bordon Tags: Research Highlight Source Type: research
T cells: A tissue checkpoint for TH2s
Nature Reviews Immunology 16, 717 (2016).
doi:10.1038/nri.2016.130
Author: Olive Leavy
A cell-intrinsic checkpoint restricts type 2 cytokine production by ILC2s and TH2 cells at sites of tissue damage. (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - November 24, 2016 Category: Allergy & Immunology Authors: Olive Leavy Tags: Research Highlight Source Type: research
A Third signal from Conditioned DCs dictates microbial effector choice
Nature Reviews Immunology 16, 721 (2016).
doi:10.1038/nri.2016.126
Author: Alan Sher
Alan Sher describes a 2002 paper by Martien Kapsenberg and Pawel Kalinski that provided evidence for the conditioning of DCs by microbial compounds to promote TH1 or TH2 cell responses. (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - November 13, 2016 Category: Allergy & Immunology Authors: Alan Sher Tags: Research Highlight Source Type: research
Macrophages: Shaping good eating habits
Nature Reviews Immunology 16, 719 (2016).
doi:10.1038/nri.2016.127
Author: Yvonne Bordon
Macrophages regulate phagocytic and inflammatory responses by non-professional phagocytes. (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - November 13, 2016 Category: Allergy & Immunology Authors: Yvonne Bordon Tags: Research Highlight Source Type: research
Do antibodies select a healthy microbiota?
Nature Reviews Immunology 16, 767 (2016).
doi:10.1038/nri.2016.114
Authors: Jason L. Kubinak & June L. Round
Disruptions to the microbiota can have pathological consequences, which highlights the need to understand the factors that contribute to its stability. Although decades of research have focused on the importance of IgA during pathogenic infection, much of the IgA that is generated in the gut (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - November 6, 2016 Category: Allergy & Immunology Authors: Jason L. Kubinak June L. Round Tags: Perspectives Source Type: research
Prime –boost strategies to embrace diversity and inclusion in immunology
Nature Reviews Immunology 16, 715 (2016).
doi:10.1038/nri.2016.122
Authors: Cherie L. Butts, Irelene P. Ricks & Avery August
Immunologists appreciate the need for creative approaches to tackle complex scientific questions, which can involve not only the use of novel technologies but also the experience of scientists from diverse backgrounds. Here, we highlight measures to prime for the inclusion of women and underrepresented individuals (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - November 6, 2016 Category: Allergy & Immunology Authors: Cherie L. Butts Irelene P. Ricks Avery August Tags: Comment Source Type: research
Food allergy: immune mechanisms, diagnosis and immunotherapy
Nature Reviews Immunology 16, 751 (2016).
doi:10.1038/nri.2016.111
Authors: Wong Yu, Deborah M. Hussey Freeland & Kari C. Nadeau
Food allergy is a pathological, potentially deadly, immune reaction triggered by normally innocuous food protein antigens. The prevalence of food allergies is rising and the standard of care is not optimal, consisting of food-allergen avoidance and treatment of allergen-induced systemic reactions with adrenaline. Thus, accurate (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - October 30, 2016 Category: Allergy & Immunology Authors: Wong Yu Deborah M. Hussey Freeland Kari C. Nadeau Tags: Review Source Type: research
Antibodies: Marking disease states in tuberculosis
Nature Reviews Immunology 16, 660 (2016).
doi:10.1038/nri.2016.120
Author: Elisabeth Kugelberg
Antibodies from individuals with latent and active tuberculosis infections show distinct glycosylation patterns and Fc-dependent effector functions. (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - October 25, 2016 Category: Allergy & Immunology Authors: Elisabeth Kugelberg Tags: Research Highlight Source Type: research
Regulatory T CELLS: Suppressing antibody production
Nature Reviews Immunology 16, 659 (2016).
doi:10.1038/nri.2016.121
Author: Olive Leavy
T follicular regulatory cells suppress antibody production through the induction of a unique suppressive state in T follicular helper cells and B cells. (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - October 25, 2016 Category: Allergy & Immunology Authors: Olive Leavy Tags: Research Highlight Source Type: research
Tumour immunology: Suppressive metabolites
Nature Reviews Immunology 16, 658 (2016).
doi:10.1038/nri.2016.119
Author: Anna Dart
Tumour-derived lactic acid dampens the activation and cytokine production of infiltrating T cells and natural killer cells, allowing tumours to escape immune detection and promoting tumour growth. (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - October 25, 2016 Category: Allergy & Immunology Authors: Anna Dart Tags: Research Highlight Source Type: research
T cell development: Shaping organ-specific γδ T cells
Nature Reviews Immunology 16, 658 (2016).
doi:10.1038/nri.2016.118
Author: Kirsty Minton
Epithelium-derived butyrophilin-like (BTNL) molecules can shape the local γδ T cell repertoire in a tissue-specific manner. (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - October 25, 2016 Category: Allergy & Immunology Authors: Kirsty Minton Tags: Research Highlight Source Type: research
Immunogenic cell death in cancer and infectious disease
Nature Reviews Immunology 17, 97 (2017).
doi:10.1038/nri.2016.107
Authors: Lorenzo Galluzzi, Aitziber Buqué, Oliver Kepp, Laurence Zitvogel & Guido Kroemer
Immunogenicity depends on two key factors: antigenicity and adjuvanticity. The presence of exogenous or mutated antigens explains why infected cells and malignant cells can initiate an adaptive immune response provided that the cells also emit adjuvant signals as a consequence of cellular stress and death. (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - October 16, 2016 Category: Allergy & Immunology Authors: Lorenzo Galluzzi Aitziber Buqu é Oliver Kepp Laurence Zitvogel Guido Kroemer Tags: Review Source Type: research
Dendritic cells: Sorting, sorted!
Nature Reviews Immunology 16, 657 (2016).
doi:10.1038/nri.2016.115
Author: Yvonne Bordon
Automated analyses of high-dimensional data can align dendritic cell subsets from different tissues and across species. (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - October 16, 2016 Category: Allergy & Immunology Authors: Yvonne Bordon Tags: Research Highlight Source Type: research
Regulation of T cell signalling by membrane lipids
Nature Reviews Immunology 16, 690 (2016).
doi:10.1038/nri.2016.103
Authors: Wei Wu, Xiaoshan Shi & Chenqi Xu
The plasma membrane is an essential cellular structure that separates the cell interior from the extracellular environment, while allowing for the exchange of signals and materials that are essential for cell survival and function. The complexity of the lipids in the plasma membrane has been (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - October 9, 2016 Category: Allergy & Immunology Authors: Wei Wu Xiaoshan Shi Chenqi Xu Tags: Review Source Type: research
